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Journal Abstract Search


101 related items for PubMed ID: 9495869

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  • 3. Isolation from pig liver microsomes, identification by electrospray tandem mass spectrometry and in vitro immunosuppressive activity of a rapamycin tris-epoxide metabolite.
    Lhoëst G, Zey T, Verbeeck RK, Wallemacq P, Maton N, De Houx JP, Latinne D.
    J Mass Spectrom; 1999 Jan; 34(1):28-32. PubMed ID: 10028689
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  • 4. In vitro immunosuppressive activity of tacrolimus dihydrodiol precursors obtained by chemical oxidation and identification of a new metabolite of SDZ-RAD by electrospray and electrospray-linked scan mass spectrometry.
    Lhoëst G, Hertsens R, Verbeeck RK, Maton N, Wallemacq P, Dehoux JP, Latinne D.
    J Mass Spectrom; 2001 Aug; 36(8):889-901. PubMed ID: 11523088
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  • 5. Isolation, identification and immunosuppressive activity of a new IMM-125 metabolite from human liver microsomes. Identification of its cyclophilin A-IMM-125 metabolite complex by nanospray tandem mass spectrometry.
    Lhoëst GJ, de Jong AP, Meiring HD, Maton N, Latinne D, Verbeeck RK, Otte JB, Zurini M.
    J Mass Spectrom; 1998 Oct; 33(10):936-42. PubMed ID: 9821326
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  • 6. The in vitro immunosuppressive activity of the C15-demethylated metabolite of FK-506 is governed by ring- and open-chain tautomerism effects.
    Lhoëst G, Verbeeck RK, Maton N, Muthelet P, Latinne D.
    J Pharmacol Exp Ther; 1995 Aug; 274(2):622-6. PubMed ID: 7543569
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  • 7. Isolation and identification of a novel isomerized epoxide metabolite of FK-506 from erythromycin-induced rabbit liver microsomes.
    Lhoëst G, Maton N, Verbeeck RK.
    Drug Metab Dispos; 1993 Aug; 21(5):850-4. PubMed ID: 7694828
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  • 8. Further metabolism of FK506 (tacrolimus). Identification and biological activities of the metabolites oxidized at multiple sites of FK506.
    Iwasaki K, Shiraga T, Matsuda H, Nagase K, Tokuma Y, Hata T, Fujii Y, Sakuma S, Fujitsu T, Fujikawa A.
    Drug Metab Dispos; 1995 Jan; 23(1):28-34. PubMed ID: 7536652
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  • 9. Isolation, identification, and biological activities of oxidative metabolites of FK506, a potent immunosuppressive macrolide lactone.
    Iwasaki K, Shiraga T, Nagase K, Tozuka Z, Noda K, Sakuma S, Fujitsu T, Shimatani K, Sato A, Fujioka M.
    Drug Metab Dispos; 1993 Jan; 21(6):971-7. PubMed ID: 7507815
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  • 10. Species-dependent hepatic metabolism of immunosuppressive agent tacrolimus (FK-506).
    Tata PN, Subbotina N, Burckart GJ, Muddiman DC, Gusev AI, Hercules DM, Starzl TE, Venkataramanan R.
    Xenobiotica; 2009 Oct; 39(10):757-65. PubMed ID: 19604035
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  • 11. Isolation and identification of a C39 demethylated metabolite of rapamycin from pig liver microsomes and evaluation of its immunosuppressive activity.
    Nickmilder MJ, Latinne D, De Houx JP, Verbeeck RK, Lhoëst GJ.
    Clin Chem; 1998 Mar; 44(3):532-8. PubMed ID: 9510858
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  • 12. Metabolism of cyadox in rat, chicken and pig liver microsomes and identification of metabolites by accurate mass measurements using electrospray ionization hybrid ion trap/time-of-flight mass spectrometry.
    Liu Z, Huang L, Dai M, Chen D, Tao Y, Wang Y, Yuan Z.
    Rapid Commun Mass Spectrom; 2009 Jul; 23(13):2026-34. PubMed ID: 19504544
    [Abstract] [Full Text] [Related]

  • 13. Isolation and mass spectrometric identification of two metabolites of FK 506 from rat liver microsomal incubation media.
    Lhoëst G, Maton N, Verbeeck R.
    Pharm Acta Helv; 1992 Jul; 67(9-10):270-4. PubMed ID: 1279730
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  • 14. FK 506 (Tacrolimus) metabolism by rat liver microsomes and its inhibition by other drugs.
    Prasad TN, Stiff DD, Subbotina N, Zemaitis MA, Burckart GJ, Starzl TE, Venkataramanan R.
    Res Commun Chem Pathol Pharmacol; 1994 Apr; 84(1):35-46. PubMed ID: 7518966
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  • 15. FK-506, a potent novel immunosuppressive agent, binds to a cytosolic protein which is distinct from the cyclosporin A-binding protein, cyclophilin.
    Siekierka JJ, Staruch MJ, Hung SH, Sigal NH.
    J Immunol; 1989 Sep 01; 143(5):1580-3. PubMed ID: 2474605
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  • 16. Identification of new flavone-8-acetic acid metabolites using mouse microsomes and comparison with human microsomes.
    Pham MH, Auzeil N, Regazzetti A, Dauzonne D, Dugay A, Menet MC, Scherman D, Chabot GG.
    Drug Metab Dispos; 2007 Nov 01; 35(11):2023-34. PubMed ID: 17664249
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  • 17. Isolation of two immunosuppressive metabolites after in vitro metabolism of rapamycin.
    Christians U, Sattler M, Schiebel HM, Kruse C, Radeke HH, Linck A, Sewing KF.
    Drug Metab Dispos; 1992 Nov 01; 20(2):186-91. PubMed ID: 1352208
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  • 18. FK 506 metabolism in male and female rat liver microsomes.
    Perotti BY, Okudaira N, Prueksaritanont T, Benet LZ.
    Drug Metab Dispos; 1994 Nov 01; 22(1):85-9. PubMed ID: 7512020
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  • 19. 15-Desmethyl FK-506 and 15,31-desmethyl FK-506 from human liver microsomes: isolation, identification (by fast atom bombardment mass spectrometry and NMR), and evaluation of in vitro immunosuppressive activity.
    Lhöest GJ, Maton N, Latinne D, Laurent A, Verbeeck RK.
    Clin Chem; 1994 May 01; 40(5):740-4. PubMed ID: 7513627
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  • 20. Use of mixed lymphocyte reaction to identify subimmunosuppressive FK-506 levels in mice.
    Ellis RA, Brenner MJ, Mackinnon SE, Myckatyn TM, Hunter DA.
    Microsurgery; 2003 May 01; 23(3):276-82. PubMed ID: 12833332
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