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Journal Abstract Search

109 related items for PubMed ID: 9496886

  • 21. Toward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
    Johnson KM, Parsons ZD, Barnes CL, Gates KS.
    J Org Chem; 2014 Aug 15; 79(16):7520-31. PubMed ID: 25029663
    [Abstract] [Full Text] [Related]

  • 22. Reductive activation of 5-fluorodeoxyuridine prodrug possessing azide methyl group by hypoxic X-irradiation.
    Tanabe K, Ishizaki J, Ando Y, Ito T, Nishimoto S.
    Bioorg Med Chem Lett; 2012 Feb 15; 22(4):1682-5. PubMed ID: 22248856
    [Abstract] [Full Text] [Related]

  • 23. Self-immolative nitrogen mustard prodrugs for suicide gene therapy.
    Niculescu-Duvaz D, Niculescu-Duvaz I, Friedlos F, Martin J, Spooner R, Davies L, Marais R, Springer CJ.
    J Med Chem; 1998 Dec 17; 41(26):5297-309. PubMed ID: 9857097
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  • 24. Studies on the mechanisms of activation of indolequinone phosphoramidate prodrugs.
    Hernick M, Borch RF.
    J Med Chem; 2003 Jan 02; 46(1):148-54. PubMed ID: 12502368
    [Abstract] [Full Text] [Related]

  • 25. Pulse radiolysis studies on the hypoxia-selective toxicity of a colbalt-mustard complex.
    Anderson RF, Denny WA, Ware DC, Wilson WR.
    Br J Cancer Suppl; 1996 Jul 02; 27():S48-51. PubMed ID: 8763845
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  • 26. Synthesis and one-electron reduction characteristics of radiation-activated prodrugs possessing two 5-fluorodeoxyuridine units.
    Tanabe K, Sugiura M, Ito T, Nishimoto S.
    Bioorg Med Chem; 2012 Sep 01; 20(17):5164-8. PubMed ID: 22847019
    [Abstract] [Full Text] [Related]

  • 27. Pharmacokinetics and metabolism of the nitrogen mustard bioreductive drug 5.
    Kestell P, Pruijn FB, Siim BG, Palmer BD, Wilson WR.
    Cancer Chemother Pharmacol; 2000 Sep 01; 46(5):365-74. PubMed ID: 11127940
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  • 28. Antagonism in effectiveness of evofosfamide and doxorubicin through intermolecular electron transfer.
    Anderson RF, Li D, Hunter FW.
    Free Radic Biol Med; 2017 Dec 01; 113():564-570. PubMed ID: 29111232
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  • 29. Sulfoxide-containing aromatic nitrogen mustards as hypoxia-directed bioreductive cytotoxins.
    Sun ZY, Botros E, Su AD, Kim Y, Wang E, Baturay NZ, Kwon CH.
    J Med Chem; 2000 Nov 02; 43(22):4160-8. PubMed ID: 11063612
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  • 30. Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs.
    Hu L, Wu X, Han J, Chen L, Vass SO, Browne P, Hall BS, Bot C, Gobalakrishnapillai V, Searle PF, Knox RJ, Wilkinson SR.
    Bioorg Med Chem Lett; 2011 Jul 01; 21(13):3986-91. PubMed ID: 21620697
    [Abstract] [Full Text] [Related]

  • 31. A novel design strategy for stable metal complexes of nitrogen mustards as bioreductive prodrugs.
    Parker LL, Lacy SM, Farrugia LJ, Evans C, Robins DJ, O'Hare CC, Hartley JA, Jaffar M, Stratford IJ.
    J Med Chem; 2004 Nov 04; 47(23):5683-9. PubMed ID: 15509167
    [Abstract] [Full Text] [Related]

  • 32. Aziridinium ion ring formation from nitrogen mustards: mechanistic insights from ab initio dynamics.
    Mann DJ.
    J Phys Chem A; 2010 Apr 08; 114(13):4486-93. PubMed ID: 20222705
    [Abstract] [Full Text] [Related]

  • 33. Bioreducible mustards: a paradigm for hypoxia-selective prodrugs of diffusible cytotoxins (HPDCs).
    Denny WA, Wilson WR.
    Cancer Metastasis Rev; 1993 Jun 08; 12(2):135-51. PubMed ID: 8375017
    [Abstract] [Full Text] [Related]

  • 34. Radiolytic activation of a cytarabine prodrug possessing a 2-oxoalkyl group: one-electron reduction and cytotoxicity characteristics.
    Hirata N, Fujisawa Y, Tanabe K, Harada H, Hiraoka M, Nishimoto S.
    Org Biomol Chem; 2009 Feb 21; 7(4):651-4. PubMed ID: 19194578
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  • 35. Radiolytic and cellular reduction of a novel hypoxia-activated cobalt(III) prodrug of a chloromethylbenzindoline DNA minor groove alkylator.
    Ahn GO, Botting KJ, Patterson AV, Ware DC, Tercel M, Wilson WR.
    Biochem Pharmacol; 2006 Jun 14; 71(12):1683-94. PubMed ID: 16620789
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  • 36. Sensitive liquid chromatographic assay for the basic DNA intercalator (N,N-dimethylaminoethyl)-9-amino-5-methylacridine-4-carboxamide and its nitroarylmethyl quaternary prodrugs in biological samples.
    Ferry DM, van Zijl PL, Wilson WR.
    J Chromatogr B Biomed Sci Appl; 2001 Nov 05; 763(1-2):149-56. PubMed ID: 11710573
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  • 37. Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: distinct mechanisms of bioreductive activation.
    Helsby NA, Wheeler SJ, Pruijn FB, Palmer BD, Yang S, Denny WA, Wilson WR.
    Chem Res Toxicol; 2003 Apr 05; 16(4):469-78. PubMed ID: 12703963
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  • 38. Characterization and study of piperazinium salts, degradation products of nitrogen mustards by nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry.
    Lee JY, Lee YH, Byun YG.
    J Chromatogr A; 2012 Mar 02; 1227():163-73. PubMed ID: 22296978
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  • 39. Synthesis and biological evaluation of hypoxia-activated prodrugs of SN-38.
    Jin C, Zhang Q, Lu W.
    Eur J Med Chem; 2017 May 26; 132():135-141. PubMed ID: 28350997
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  • 40. Synthesis and evaluation of stable bidentate transition metal complexes of 1-(chloromethyl)-5-hydroxy-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline (seco-6-azaCBI-TMI) as hypoxia selective cytotoxins.
    Milbank JB, Stevenson RJ, Ware DC, Chang JY, Tercel M, Ahn GO, Wilson WR, Denny WA.
    J Med Chem; 2009 Nov 12; 52(21):6822-34. PubMed ID: 19821576
    [Abstract] [Full Text] [Related]

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