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176 related items for PubMed ID: 9521777

  • 1. Mechanism of phosphatidylinositol-specific phospholipase C: a unified view of the mechanism of catalysis.
    Hondal RJ, Zhao Z, Kravchuk AV, Liao H, Riddle SR, Yue X, Bruzik KS, Tsai MD.
    Biochemistry; 1998 Mar 31; 37(13):4568-80. PubMed ID: 9521777
    [Abstract] [Full Text] [Related]

  • 2. Phosphatidylinositol-specific phospholipase C: kinetic and stereochemical evidence for an interaction between arginine-69 and the phosphate group of phosphatidylinositol.
    Hondal RJ, Riddle SR, Kravchuk AV, Zhao Z, Liao H, Bruzik KS, Tsai MD.
    Biochemistry; 1997 Jun 03; 36(22):6633-42. PubMed ID: 9184143
    [Abstract] [Full Text] [Related]

  • 3. Probing the roles of active site residues in phosphatidylinositol-specific phospholipase C from Bacillus cereus by site-directed mutagenesis.
    Gässler CS, Ryan M, Liu T, Griffith OH, Heinz DW.
    Biochemistry; 1997 Oct 21; 36(42):12802-13. PubMed ID: 9335537
    [Abstract] [Full Text] [Related]

  • 4. Involvement of the Arg-Asp-His catalytic triad in enzymatic cleavage of the phosphodiester bond.
    Kubiak RJ, Yue X, Hondal RJ, Mihai C, Tsai MD, Bruzik KS.
    Biochemistry; 2001 May 08; 40(18):5422-32. PubMed ID: 11331006
    [Abstract] [Full Text] [Related]

  • 5. A catalytic diad involved in substrate-assisted catalysis: NMR study of hydrogen bonding and dynamics at the active site of phosphatidylinositol-specific phospholipase C.
    Ryan M, Liu T, Dahlquist FW, Griffith OH.
    Biochemistry; 2001 Aug 14; 40(32):9743-50. PubMed ID: 11583175
    [Abstract] [Full Text] [Related]

  • 6. Application of Brønsted-type LFER in the study of the phospholipase C mechanism.
    Mihai C, Kravchuk AV, Tsai MD, Bruzik KS.
    J Am Chem Soc; 2003 Mar 19; 125(11):3236-42. PubMed ID: 12630878
    [Abstract] [Full Text] [Related]

  • 7. Engineering a catalytic metal binding site into a calcium-independent phosphatidylinositol-specific phospholipase C leads to enhanced stereoselectivity.
    Kravchuk AV, Zhao L, Bruzik KS, Tsai MD.
    Biochemistry; 2003 Mar 04; 42(8):2422-30. PubMed ID: 12600209
    [Abstract] [Full Text] [Related]

  • 8. X-ray structure of the R69D phosphatidylinositol-specific phospholipase C enzyme: insight into the role of calcium and surrounding amino acids in active site geometry and catalysis.
    Apiyo D, Zhao L, Tsai MD, Selby TL.
    Biochemistry; 2005 Aug 02; 44(30):9980-9. PubMed ID: 16042375
    [Abstract] [Full Text] [Related]

  • 9. Mutation of two active-site residues converts a phosphatidylinositol-specific phospholipase C to a glucose phosphatase.
    Feng J, Stieglitz K, Roberts MF.
    J Am Chem Soc; 2004 Feb 04; 126(4):1008-9. PubMed ID: 14746454
    [Abstract] [Full Text] [Related]

  • 10. Altering substrate specificity of phosphatidylcholine-preferring phospholipase C of Bacillus cereus by random mutagenesis of the headgroup binding site.
    Antikainen NM, Hergenrother PJ, Harris MM, Corbett W, Martin SF.
    Biochemistry; 2003 Feb 18; 42(6):1603-10. PubMed ID: 12578373
    [Abstract] [Full Text] [Related]

  • 11. Probing the function of Asp128 in the lower molecular weight protein-tyrosine phosphatase-catalyzed reaction. A pre-steady-state and steady-state kinetic investigation.
    Wu L, Zhang ZY.
    Biochemistry; 1996 Apr 30; 35(17):5426-34. PubMed ID: 8611532
    [Abstract] [Full Text] [Related]

  • 12. Crystal structure of the phosphatidylinositol-specific phospholipase C from the human pathogen Listeria monocytogenes.
    Moser J, Gerstel B, Meyer JE, Chakraborty T, Wehland J, Heinz DW.
    J Mol Biol; 1997 Oct 17; 273(1):269-82. PubMed ID: 9367761
    [Abstract] [Full Text] [Related]

  • 13. General base catalysis by the phosphatidylcholine-preferring phospholipase C from Bacillus cereus: the role of Glu4 and Asp55.
    Martin SF, Hergenrother PJ.
    Biochemistry; 1998 Apr 21; 37(16):5755-60. PubMed ID: 9548962
    [Abstract] [Full Text] [Related]

  • 14. The catalytic role of aspartate in a short strong hydrogen bond of the Asp274-His32 catalytic dyad in phosphatidylinositol-specific phospholipase C can be substituted by a chloride ion.
    Zhao L, Liao H, Tsai MD.
    J Biol Chem; 2004 Jul 30; 279(31):31995-2000. PubMed ID: 15155721
    [Abstract] [Full Text] [Related]

  • 15. Determination of pKa values of the histidine side chains of phosphatidylinositol-specific phospholipase C from Bacillus cereus by NMR spectroscopy and site-directed mutagenesis.
    Liu T, Ryan M, Dahlquist FW, Griffith OH.
    Protein Sci; 1997 Sep 30; 6(9):1937-44. PubMed ID: 9300493
    [Abstract] [Full Text] [Related]

  • 16. Short-chain phosphatidylinositol conformation and its relevance to phosphatidylinositol-specific phospholipase C.
    Zhou C, Garigapati V, Roberts MF.
    Biochemistry; 1997 Dec 16; 36(50):15925-31. PubMed ID: 9398326
    [Abstract] [Full Text] [Related]

  • 17. Role of aspartate-133 and histidine-458 in the mechanism of tryptophan indole-lyase from Proteus vulgaris.
    Demidkina TV, Zakomirdina LN, Kulikova VV, Dementieva IS, Faleev NG, Ronda L, Mozzarelli A, Gollnick PD, Phillips RS.
    Biochemistry; 2003 Sep 30; 42(38):11161-9. PubMed ID: 14503866
    [Abstract] [Full Text] [Related]

  • 18. Site-directed mutagenesis, kinetic, and spectroscopic studies of the P-loop residues in a low molecular weight protein tyrosine phosphatase.
    Evans B, Tishmack PA, Pokalsky C, Zhang M, Van Etten RL.
    Biochemistry; 1996 Oct 22; 35(42):13609-17. PubMed ID: 8885840
    [Abstract] [Full Text] [Related]

  • 19. Expression and site-directed mutagenesis of the phosphatidylcholine-preferring phospholipase C of Bacillus cereus: probing the role of the active site Glu146.
    Martin SF, Spaller MR, Hergenrother PJ.
    Biochemistry; 1996 Oct 01; 35(39):12970-7. PubMed ID: 8841144
    [Abstract] [Full Text] [Related]

  • 20. Activation of phosphatidylinositol-specific phospholipase C toward inositol 1,2-(cyclic)-phosphate.
    Zhou C, Wu Y, Roberts MF.
    Biochemistry; 1997 Jan 14; 36(2):347-55. PubMed ID: 9003187
    [Abstract] [Full Text] [Related]

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