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Journal Abstract Search

145 related items for PubMed ID: 9523802

  • 1. Cysteine conjugate beta-lyase-dependent metabolism of compound A (2-[fluoromethoxy]-1,1,3,3,3-pentafluoro-1-propene) in human subjects anesthetized with sevoflurane and in rats given compound A.
    Iyer RA, Frink EJ, Ebert TJ, Anders MW.
    Anesthesiology; 1998 Mar; 88(3):611-8. PubMed ID: 9523802
    [Abstract] [Full Text] [Related]

  • 2. Cysteine conjugate beta-lyase-dependent biotransformation of the cysteine S-conjugates of the sevoflurane degradation product 2-(fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (compound A).
    Iyer RA, Anders MW.
    Chem Res Toxicol; 1997 Jul; 10(7):811-9. PubMed ID: 9250416
    [Abstract] [Full Text] [Related]

  • 3. Fate and toxicity of 2-(fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (compound A)-derived mercapturates in male, Fischer 344 rats.
    Uttamsingh V, Iyer RA, Baggs RB, Anders MW.
    Anesthesiology; 1998 Nov; 89(5):1174-83. PubMed ID: 9822006
    [Abstract] [Full Text] [Related]

  • 4. Evidence for metabolism of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product, by cysteine conjugate beta-lyase.
    Spracklin DK, Kharasch ED.
    Chem Res Toxicol; 1996 Jun; 9(4):696-702. PubMed ID: 8831812
    [Abstract] [Full Text] [Related]

  • 5. Dose-dependent metabolism of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), an anesthetic degradation product, to mercapturic acids and 3,3,3-trifluoro-2-(fluoromethoxy)propanoic acid in rats.
    Kharasch ED, Jubert C, Spracklin DK, Hoffman GM.
    Toxicol Appl Pharmacol; 1999 Oct 01; 160(1):49-59. PubMed ID: 10502502
    [Abstract] [Full Text] [Related]

  • 6. Nephrotoxicity of the glutathione and cysteine S-conjugates of the sevoflurane degradation product 2-(fluoromethoxy)-1,1,3,3, 3-pentafluoro-1-propene (Compound A) in male Fischer 344 rats.
    Iyer RA, Baggs RB, Anders MW.
    J Pharmacol Exp Ther; 1997 Dec 01; 283(3):1544-51. PubMed ID: 9400032
    [Abstract] [Full Text] [Related]

  • 7. Cysteine conjugate beta-lyase-dependent biotransformation of the cysteine S-conjugates of the sevoflurane degradation product compound A in human, nonhuman primate, and rat kidney cytosol and mitochondria.
    Iyer RA, Anders MW.
    Anesthesiology; 1996 Dec 01; 85(6):1454-61. PubMed ID: 8968194
    [Abstract] [Full Text] [Related]

  • 8. Reactive intermediate formation from the 2-(Fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (compound A)-derived cysteine S-conjugate S-[2-(Fluoromethoxy)-1,1,3,3,3-pentafluoropropyl]-L-cysteine in pyridoxal model systems.
    Tong Z, Anders MW.
    Chem Res Toxicol; 2002 May 01; 15(5):623-8. PubMed ID: 12018982
    [Abstract] [Full Text] [Related]

  • 9. Role of renal cysteine conjugate beta-lyase in the mechanism of compound A nephrotoxicity in rats.
    Kharasch ED, Thorning D, Garton K, Hankins DC, Kilty CG.
    Anesthesiology; 1997 Jan 01; 86(1):160-71. PubMed ID: 9009951
    [Abstract] [Full Text] [Related]

  • 10. Biotransformation of L-cysteine S-conjugates and N-acetyl-L-cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human kidney in vitro: interindividual variability in N-acetylation, N-deacetylation, and beta-lyase-catalyzed metabolism.
    Gul Altuntas T, Kharasch ED.
    Drug Metab Dispos; 2002 Feb 01; 30(2):148-54. PubMed ID: 11792683
    [Abstract] [Full Text] [Related]

  • 11. Compound A uptake and metabolism to mercapturic acids and 3,3,3-trifluoro-2-fluoromethoxypropanoic acid during low-flow sevoflurane anesthesia: biomarkers for exposure, risk assessment, and interspecies comparison.
    Kharasch ED, Jubert C.
    Anesthesiology; 1999 Nov 01; 91(5):1267-78. PubMed ID: 10551576
    [Abstract] [Full Text] [Related]

  • 12. Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats.
    Sheffels P, Schroeder JL, Altuntas TG, Liggitt HD, Kharasch ED.
    Chem Res Toxicol; 2004 Sep 01; 17(9):1177-89. PubMed ID: 15377151
    [Abstract] [Full Text] [Related]

  • 13. Use of 19F-nuclear magnetic resonance and gas chromatography-electron capture detection in the quantitative analysis of fluorine-containing metabolites in urine of sevoflurane-anaesthetized patients.
    Orhan H, Commandeur JN, Sahin G, Aypar U, Sahin A, Vermeulen NP.
    Xenobiotica; 2004 Mar 01; 34(3):301-16. PubMed ID: 15204701
    [Abstract] [Full Text] [Related]

  • 14. Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line.
    Altuntas TG, Zager RA, Kharasch ED.
    Toxicol Appl Pharmacol; 2003 Nov 15; 193(1):55-65. PubMed ID: 14613716
    [Abstract] [Full Text] [Related]

  • 15. Nephrotoxicity of sevoflurane compound A [fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether] in rats: evidence for glutathione and cysteine conjugate formation and the role of renal cysteine conjugate beta-lyase.
    Jin L, Baillie TA, Davis MR, Kharasch ED.
    Biochem Biophys Res Commun; 1995 May 16; 210(2):498-506. PubMed ID: 7755627
    [Abstract] [Full Text] [Related]

  • 16. Immunochemical evidence against the involvement of cysteine conjugate beta-lyase in compound A nephrotoxicity in rats.
    Njoku DB, Pohl LR, Sokoloski EA, Marchick MR, Borkowf CB, Martin JL.
    Anesthesiology; 1999 Feb 16; 90(2):458-69. PubMed ID: 9952153
    [Abstract] [Full Text] [Related]

  • 17. Influence of sevoflurane on the metabolism and renal effects of compound A in rats.
    Kharasch ED, Schroeder JL, Sheffels P, Liggitt HD.
    Anesthesiology; 2005 Dec 16; 103(6):1183-8. PubMed ID: 16306730
    [Abstract] [Full Text] [Related]

  • 18. Baralyme dehydration increases and soda lime dehydration decreases the concentration of compound A resulting from sevoflurane degradation in a standard anesthetic circuit.
    Eger EI, Ionescu P, Laster MJ, Weiskopf RB.
    Anesth Analg; 1997 Oct 16; 85(4):892-8. PubMed ID: 9322476
    [Abstract] [Full Text] [Related]

  • 19. Role of the renal cysteine conjugate beta-lyase pathway in inhaled compound A nephrotoxicity in rats.
    Kharasch ED, Hoffman GM, Thorning D, Hankins DC, Kilty CG.
    Anesthesiology; 1998 Jun 16; 88(6):1624-33. PubMed ID: 9637657
    [Abstract] [Full Text] [Related]

  • 20. Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A).
    Altuntas TG, Park SB, Kharasch ED.
    Chem Res Toxicol; 2004 Mar 16; 17(3):435-45. PubMed ID: 15025515
    [Abstract] [Full Text] [Related]

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