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Journal Abstract Search

131 related items for PubMed ID: 9524554

  • 1. 5-substituted analogues of 3-hydroxymethyl-5-aziridinyl-1-methyl-2-[1H-indole-4,7-dione]prop-2-en- 1-ol (EO9, NSC 382459) and their regioisomers as hypoxia-selective agents: structure-cytotoxicity in vitro.
    Jaffar M, Naylor MA, Robertson N, Lockyer SD, Phillips RM, Everett SA, Adams GE, Stratford IJ.
    Anticancer Drug Des; 1998 Mar; 13(2):105-23. PubMed ID: 9524554
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  • 2. Bioreductive activation of a series of analogues of 5-aziridinyl-3-hydroxymethyl-1-methyl-2-[1H-indole-4, 7-dione] prop-beta-en-alpha-ol (EO9) by human DT-diaphorase.
    Phillips RM.
    Biochem Pharmacol; 1996 Dec 13; 52(11):1711-8. PubMed ID: 8986133
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  • 3. Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice.
    Loadman PM, Phillips RM, Lim LE, Bibby MC.
    Biochem Pharmacol; 2000 Apr 01; 59(7):831-7. PubMed ID: 10718341
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  • 5. Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia.
    Robertson N, Haigh A, Adams GE, Stratford IJ.
    Eur J Cancer; 1994 Apr 01; 30A(7):1013-9. PubMed ID: 7946565
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  • 6. The relative importance of NADPH: cytochrome c (P450) reductase for determining the sensitivity of human tumour cells to the indolequinone EO9 and related analogues lacking functionality at the C-2 and C-3 positions.
    Saunders MP, Jaffar M, Patterson AV, Nolan J, Naylor MA, Phillips RM, Harris AL, Stratford IJ.
    Biochem Pharmacol; 2000 Apr 15; 59(8):993-6. PubMed ID: 10692564
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  • 7. Bioreductive activation of a series of indolequinones by human DT-diaphorase: structure-activity relationships.
    Phillips RM, Naylor MA, Jaffar M, Doughty SW, Everett SA, Breen AG, Choudry GA, Stratford IJ.
    J Med Chem; 1999 Oct 07; 42(20):4071-80. PubMed ID: 10514277
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  • 8. Structure-activity relationships for DT-diaphorase reduction of hypoxic cell directed agents: indoloquinones and diaziridinyl benzoquinones.
    Bailey SM, Suggett N, Walton MI, Workman P.
    Int J Radiat Oncol Biol Phys; 1992 Oct 07; 22(4):649-53. PubMed ID: 1544832
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  • 11. The sensitivity of human tumour cells to quinone bioreductive drugs: what role for DT-diaphorase?
    Robertson N, Stratford IJ, Houlbrook S, Carmichael J, Adams GE.
    Biochem Pharmacol; 1992 Aug 04; 44(3):409-12. PubMed ID: 1510692
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  • 12. EO9: relationship between DT-diaphorase levels and response in vitro and in vivo.
    Collard J, Matthew AM, Double JA, Bibby MC.
    Br J Cancer; 1995 Jun 04; 71(6):1199-203. PubMed ID: 7779711
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  • 13. The role of NAD(P)H: quinone reductase (EC 1.6.99.2, DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent EO9.
    Walton MI, Smith PJ, Workman P.
    Cancer Commun; 1991 Jul 04; 3(7):199-206. PubMed ID: 1714284
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  • 15. Relative importance of DT-diaphorase and hypoxia in the bioactivation of EO9 by human lung tumor cell lines.
    Plumb JA, Gerritsen M, Milroy R, Thomson P, Workman P.
    Int J Radiat Oncol Biol Phys; 1994 May 15; 29(2):295-9. PubMed ID: 8195022
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  • 17. Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9.
    Bailey SM, Wyatt MD, Friedlos F, Hartley JA, Knox RJ, Lewis AD, Workman P.
    Br J Cancer; 1997 May 15; 76(12):1596-603. PubMed ID: 9413948
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  • 19. Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expression.
    Smitskamp-Wilms E, Peters GJ, Pinedo HM, van Ark-Otte J, Giaccone G.
    Biochem Pharmacol; 1994 Apr 20; 47(8):1325-32. PubMed ID: 7514407
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  • 20. A comparison of the cytotoxic and physical properties of aziridinyl quinone derivatives based on the pyrrolo[1,2-a]benzimidazole and pyrrolo[1,2-a]indole ring systems.
    Boruah RC, Skibo EB.
    J Med Chem; 1994 May 27; 37(11):1625-31. PubMed ID: 8201596
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