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Journal Abstract Search

199 related items for PubMed ID: 9538011

  • 1. Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase leads to polyketide biosynthesis.
    Jacobsen JR, Cane DE, Khosla C.
    Biochemistry; 1998 Apr 07; 37(14):4928-34. PubMed ID: 9538011
    [Abstract] [Full Text] [Related]

  • 2. Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units.
    Lau J, Fu H, Cane DE, Khosla C.
    Biochemistry; 1999 Feb 02; 38(5):1643-51. PubMed ID: 9931032
    [Abstract] [Full Text] [Related]

  • 3. Erythromycin biosynthesis: kinetic studies on a fully active modular polyketide synthase using natural and unnatural substrates.
    Pieper R, Ebert-Khosla S, Cane D, Khosla C.
    Biochemistry; 1996 Feb 20; 35(7):2054-60. PubMed ID: 8652546
    [Abstract] [Full Text] [Related]

  • 4. Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases.
    Pieper R, Luo G, Cane DE, Khosla C.
    Nature; 1995 Nov 16; 378(6554):263-6. PubMed ID: 7477343
    [Abstract] [Full Text] [Related]

  • 5. Purification and characterization of bimodular and trimodular derivatives of the erythromycin polyketide synthase.
    Pieper R, Gokhale RS, Luo G, Cane DE, Khosla C.
    Biochemistry; 1997 Feb 18; 36(7):1846-51. PubMed ID: 9048569
    [Abstract] [Full Text] [Related]

  • 6. Origin of starter units for erythromycin biosynthesis.
    Weissman KJ, Bycroft M, Staunton J, Leadlay PF.
    Biochemistry; 1998 Aug 04; 37(31):11012-7. PubMed ID: 9692995
    [Abstract] [Full Text] [Related]

  • 7. Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules.
    Hans M, Hornung A, Dziarnowski A, Cane DE, Khosla C.
    J Am Chem Soc; 2003 May 07; 125(18):5366-74. PubMed ID: 12720450
    [Abstract] [Full Text] [Related]

  • 8. Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase.
    Kao CM, Pieper R, Cane DE, Khosla C.
    Biochemistry; 1996 Sep 24; 35(38):12363-8. PubMed ID: 8823171
    [Abstract] [Full Text] [Related]

  • 9. The molecular basis of Celmer's rules: the stereochemistry of the condensation step in chain extension on the erythromycin polyketide synthase.
    Weissman KJ, Timoney M, Bycroft M, Grice P, Hanefeld U, Staunton J, Leadlay PF.
    Biochemistry; 1997 Nov 11; 36(45):13849-55. PubMed ID: 9374862
    [Abstract] [Full Text] [Related]

  • 10. Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases.
    Liou GF, Lau J, Cane DE, Khosla C.
    Biochemistry; 2003 Jan 14; 42(1):200-7. PubMed ID: 12515555
    [Abstract] [Full Text] [Related]

  • 11. Enhancing the modularity of the modular polyketide synthases: transacylation in modular polyketide synthases catalyzed by malonyl-CoA:ACP transacylase.
    Kumar P, Koppisch AT, Cane DE, Khosla C.
    J Am Chem Soc; 2003 Nov 26; 125(47):14307-12. PubMed ID: 14624579
    [Abstract] [Full Text] [Related]

  • 12. 6-Deoxyerythronolide B analogue production in Escherichia coli through metabolic pathway engineering.
    Kennedy J, Murli S, Kealey JT.
    Biochemistry; 2003 Dec 09; 42(48):14342-8. PubMed ID: 14640703
    [Abstract] [Full Text] [Related]

  • 13. Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1.
    Murli S, MacMillan KS, Hu Z, Ashley GW, Dong SD, Kealey JT, Reeves CD, Kennedy J.
    Appl Environ Microbiol; 2005 Aug 09; 71(8):4503-9. PubMed ID: 16085842
    [Abstract] [Full Text] [Related]

  • 14. Functional orientation of the acyltransferase domain in a module of the erythromycin polyketide synthase.
    Gokhale RS, Lau J, Cane DE, Khosla C.
    Biochemistry; 1998 Feb 24; 37(8):2524-8. PubMed ID: 9485401
    [Abstract] [Full Text] [Related]

  • 15. 6-deoxyerythronolide B synthase 1 is specifically acylated by a diketide intermediate at the beta-ketoacyl-acyl carrier protein synthase domain of module 2.
    Tsukamoto N, Chuck JA, Luo G, Kao CM, Khosla C, Cane DE.
    Biochemistry; 1996 Dec 03; 35(48):15244-8. PubMed ID: 8952473
    [Abstract] [Full Text] [Related]

  • 16. A model of structure and catalysis for ketoreductase domains in modular polyketide synthases.
    Reid R, Piagentini M, Rodriguez E, Ashley G, Viswanathan N, Carney J, Santi DV, Hutchinson CR, McDaniel R.
    Biochemistry; 2003 Jan 14; 42(1):72-9. PubMed ID: 12515540
    [Abstract] [Full Text] [Related]

  • 17. The DEBS paradigm for type I modular polyketide synthases and beyond.
    Katz L.
    Methods Enzymol; 2009 Jan 14; 459():113-42. PubMed ID: 19362638
    [Abstract] [Full Text] [Related]

  • 18. Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase.
    Kim CY, Alekseyev VY, Chen AY, Tang Y, Cane DE, Khosla C.
    Biochemistry; 2004 Nov 09; 43(44):13892-8. PubMed ID: 15518537
    [Abstract] [Full Text] [Related]

  • 19. Expression and kinetic analysis of the substrate specificity of modules 5 and 6 of the picromycin/methymycin polyketide synthase.
    Yin Y, Lu H, Khosla C, Cane DE.
    J Am Chem Soc; 2003 May 14; 125(19):5671-6. PubMed ID: 12733905
    [Abstract] [Full Text] [Related]

  • 20. Biochemical analysis of the substrate specificity of the beta-ketoacyl-acyl carrier protein synthase domain of module 2 of the erythromycin polyketide synthase.
    Wu J, Kinoshita K, Khosla C, Cane DE.
    Biochemistry; 2004 Dec 28; 43(51):16301-10. PubMed ID: 15610024
    [Abstract] [Full Text] [Related]

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