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Journal Abstract Search

481 related items for PubMed ID: 9548816

  • 1. Selective Pneumocystis carinii dihydrofolate reductase inhibitors: design, synthesis, and biological evaluation of new 2,4-diamino-5-substituted-furo[2,3-d]pyrimidines.
    Gangjee A, Guo X, Queener SF, Cody V, Galitsky N, Luft JR, Pangborn W.
    J Med Chem; 1998 Apr 09; 41(8):1263-71. PubMed ID: 9548816
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  • 2. 2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases.
    Gangjee A, Vasudevan A, Queener SF, Kisliuk RL.
    J Med Chem; 1996 Mar 29; 39(7):1438-46. PubMed ID: 8691474
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  • 3. Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents.
    Gangjee A, Adair OO, Queener SF.
    J Med Chem; 2003 Nov 06; 46(23):5074-82. PubMed ID: 14584957
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  • 4. Conformationally restricted analogues of trimethoprim: 2,6-diamino-8-substituted purines as potential dihydrofolate reductase inhibitors from Pneumocystis carinii and Toxoplasma gondii.
    Gangjee A, Vasudevan A, Queener SF.
    J Med Chem; 1997 Sep 12; 40(19):3032-9. PubMed ID: 9301665
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  • 5. Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase inhibitors and antitumor agents: synthesis and biological activities of 2,4-diamino-5-methyl-6-[(monosubstituted anilino)methyl] pyrido[2,3-d]pyrimidines.
    Gangjee A, Adair O, Queener SF.
    J Med Chem; 1999 Jul 01; 42(13):2447-55. PubMed ID: 10395486
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  • 6. Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gondii.
    Gangjee A, Zhu Y, Queener SF, Francom P, Broom AD.
    J Med Chem; 1996 Apr 26; 39(9):1836-45. PubMed ID: 8627607
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  • 7. Effect of N9-methylation and bridge atom variation on the activity of 5-substituted 2,4-diaminopyrrolo[2,3-d]pyrimidines against dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii.
    Gangjee A, Mavandadi F, Queener SF.
    J Med Chem; 1997 Mar 28; 40(7):1173-7. PubMed ID: 9089339
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  • 18. Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase.
    Cody V, Galitsky N, Luft JR, Pangborn W, Queener SF, Gangjee A.
    Acta Crystallogr D Biol Crystallogr; 2002 Sep 28; 58(Pt 9):1393-9. PubMed ID: 12198294
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  • 19. Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations.
    Piper JR, Johnson CA, Krauth CA, Carter RL, Hosmer CA, Queener SF, Borotz SE, Pfefferkorn ER.
    J Med Chem; 1996 Mar 15; 39(6):1271-80. PubMed ID: 8632434
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  • 20. 2,4-Diaminothieno[2,3-d]pyrimidine lipophilic antifolates as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
    Rosowsky A, Papoulis AT, Queener SF.
    J Med Chem; 1997 Oct 24; 40(22):3694-9. PubMed ID: 9357537
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