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150 related items for PubMed ID: 9548897

  • 1. Effects of various protease inhibitors on the stability and permeability of [D-Ala2,D-Leu5]enkephalin in the rat intestine: comparison with leucine enkephalin.
    Uchiyama T, Kotani A, Kishida T, Tatsumi H, Okamoto A, Fujita T, Murakami M, Muranishi S, Yamamoto A.
    J Pharm Sci; 1998 Apr; 87(4):448-52. PubMed ID: 9548897
    [Abstract] [Full Text] [Related]

  • 2. Development of novel lipophilic derivatives of DADLE (leucine enkephalin analogue): intestinal permeability characateristics of DADLE derivatives in rats.
    Uchiyama T, Kotani A, Tatsumi H, Kishida T, Okamoto A, Okada N, Murakami M, Fujita T, Fujiwara Y, Kiso Y, Muranishi S, Yamamoto A.
    Pharm Res; 2000 Dec; 17(12):1461-7. PubMed ID: 11303954
    [Abstract] [Full Text] [Related]

  • 3. Studies on the transport of enkephalin-like oligopeptides in rat intestinal mucosa.
    Kerchner GA, Geary LE.
    J Pharmacol Exp Ther; 1983 Jul; 226(1):33-8. PubMed ID: 6345754
    [Abstract] [Full Text] [Related]

  • 4. Transport kinetics of leucine enkephalin across Caco-2 monolayers: quantitative analysis for contribution of enzymatic and transport barrier.
    Quan YS, Fujita T, Tohara D, Tsuji M, Kohyama M, Yamamoto A.
    Life Sci; 1999 Jul; 64(14):1243-52. PubMed ID: 10210267
    [Abstract] [Full Text] [Related]

  • 5. Significant differences in the disposition of cyclic prodrugs of opioid peptides in rats and guinea pigs following IV administration.
    Liederer BM, Phan KT, Ouyang H, Borchardt RT.
    J Pharm Sci; 2005 Dec; 94(12):2676-87. PubMed ID: 16258984
    [Abstract] [Full Text] [Related]

  • 6. Effects of amino acid chirality and the chemical linker on the cell permeation characteristics of cyclic prodrugs of opioid peptides.
    Liederer BM, Fuchs T, Vander Velde D, Siahaan TJ, Borchardt RT.
    J Med Chem; 2006 Feb 23; 49(4):1261-70. PubMed ID: 16480263
    [Abstract] [Full Text] [Related]

  • 7. Blood-brain barrier permeability to leucine-enkephalin, D-alanine2-D-leucine5-enkephalin and their N-terminal amino acid (tyrosine).
    Zlokovic BV, Begley DJ, Chain-Eliash DG.
    Brain Res; 1985 Jun 10; 336(1):125-32. PubMed ID: 3891014
    [Abstract] [Full Text] [Related]

  • 8. Stability of oxymethyl-modified coumarinic acid cyclic prodrugs of diastereomeric opioid peptides in biological media from various animal species including human.
    Liederer BM, Borchardt RT.
    J Pharm Sci; 2005 Oct 10; 94(10):2198-206. PubMed ID: 16136552
    [Abstract] [Full Text] [Related]

  • 9. Phenylpropionic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeation.
    Gudmundsson OS, Nimkar K, Gangwar S, Siahaan T, Borchardt RT.
    Pharm Res; 1999 Jan 10; 16(1):16-23. PubMed ID: 9950273
    [Abstract] [Full Text] [Related]

  • 10. Effects of (D-Ala2,D-Leu5)enkephalinamide on isolated longitudinal muscle guinea pig and rat intestines.
    Venkova K, Radomirov R, Petkov VD.
    Methods Find Exp Clin Pharmacol; 1987 May 10; 9(5):291-6. PubMed ID: 3613757
    [Abstract] [Full Text] [Related]

  • 11. Effects of peptidase inhibitors on the [Met5]-enkephalin hydrolysis in ileal and striatal preparations of guinea-pig: almost complete protection of degradation by the combination of amastatin, captopril and thiorphan.
    Hiranuma T, Oka T.
    Jpn J Pharmacol; 1986 Aug 10; 41(4):437-46. PubMed ID: 3534399
    [Abstract] [Full Text] [Related]

  • 12. Oral absorption of peptides: influence of pH and inhibitors on the intestinal hydrolysis of leu-enkephalin and analogues.
    Friedman DI, Amidon GL.
    Pharm Res; 1991 Jan 10; 8(1):93-6. PubMed ID: 2014216
    [Abstract] [Full Text] [Related]

  • 13. Effects of three peptidase inhibitors, amastatin, captopril and phosphoramidon, on the hydrolysis of [Met5]-enkephalin-Arg6-Phe7 and other opioid peptides.
    Hiranuma T, Kitamura K, Taniguchi T, Kobayashi T, Tamaki R, Kanai M, Akahori K, Iwao K, Oka T.
    Naunyn Schmiedebergs Arch Pharmacol; 1998 Mar 10; 357(3):276-82. PubMed ID: 9550299
    [Abstract] [Full Text] [Related]

  • 14. Factors that restrict intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part II. Role of metabolic enzymes in the intestinal mucosa.
    Ouyang H, Chen W, Andersen TE, Steffansen B, Borchardt RT.
    J Pharm Sci; 2009 Jan 10; 98(1):349-61. PubMed ID: 18537150
    [Abstract] [Full Text] [Related]

  • 15. Factors that restrict the intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part I. Role of efflux transporters in the intestinal mucosa.
    Ouyang H, Chen W, Andersen TE, Steffansen B, Borchardt RT.
    J Pharm Sci; 2009 Jan 10; 98(1):337-48. PubMed ID: 18537149
    [Abstract] [Full Text] [Related]

  • 16. Tolerance and cross-tolerance to the antisecretory effects of enkephalins on the guinea-pig ileal mucosa.
    Vinayek R, Brown DR, Miller RJ.
    J Pharmacol Exp Ther; 1985 Mar 10; 232(3):781-5. PubMed ID: 2983070
    [Abstract] [Full Text] [Related]

  • 17. Attempts to target antitumor drugs toward opioid receptor-rich mouse tumor cells with enkephalin-ellipticinium conjugates.
    Rigaudy P, Charcosset JY, Garbay-Jaureguiberry C, Jacquemin-Sablon A, Roques BP.
    Cancer Res; 1989 Apr 01; 49(7):1836-42. PubMed ID: 2538235
    [Abstract] [Full Text] [Related]

  • 18. An in vitro evaluation of metabolism and poor membrane permeation impeding intestinal absorption of leucine enkephalin, and methods to increase absorption.
    Aungst BJ, Blake JA, Hussain MA.
    J Pharmacol Exp Ther; 1991 Oct 01; 259(1):139-45. PubMed ID: 1920113
    [Abstract] [Full Text] [Related]

  • 19. [D-Ala2,D-Leu5]-enkephalin (DADLE) and morphine-induced postconditioning by inhibition of mitochondrial permeability transition pore, in human myocardium.
    Fuardo M, Lemoine S, Lo Coco C, Hanouz JL, Massetti M.
    Exp Biol Med (Maywood); 2013 Apr 01; 238(4):426-32. PubMed ID: 23436882
    [Abstract] [Full Text] [Related]

  • 20. Contribution of organic anion transporting polypeptide OATP-C to hepatic elimination of the opioid pentapeptide analogue [D-Ala2, D-Leu5]-enkephalin.
    Nozawa T, Tamai I, Sai Y, Nezu J, Tsuji A.
    J Pharm Pharmacol; 2003 Jul 01; 55(7):1013-20. PubMed ID: 12906759
    [Abstract] [Full Text] [Related]

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