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Journal Abstract Search

305 related items for PubMed ID: 9549641

  • 1. Five distinct human cytochromes mediate amitriptyline N-demethylation in vitro: dominance of CYP 2C19 and 3A4.
    Venkatakrishnan K, Greenblatt DJ, von Moltke LL, Schmider J, Harmatz JS, Shader RI.
    J Clin Pharmacol; 1998 Feb; 38(2):112-21. PubMed ID: 9549641
    [Abstract] [Full Text] [Related]

  • 2. Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man.
    Venkatakrishnan K, von Moltke LL, Duan SX, Fleishaker JC, Shader RI, Greenblatt DJ.
    J Pharm Pharmacol; 1998 Mar; 50(3):265-74. PubMed ID: 9600717
    [Abstract] [Full Text] [Related]

  • 3. Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: inhibition by sulfaphenazole, omeprazole, and ticlopidine.
    Giancarlo GM, Venkatakrishnan K, Granda BW, von Moltke LL, Greenblatt DJ.
    Eur J Clin Pharmacol; 2001 Apr; 57(1):31-6. PubMed ID: 11372587
    [Abstract] [Full Text] [Related]

  • 4. Hydroxylation and demethylation of the tricyclic antidepressant nortriptyline by cDNA-expressed human cytochrome P-450 isozymes.
    Olesen OV, Linnet K.
    Drug Metab Dispos; 1997 Jun; 25(6):740-4. PubMed ID: 9193876
    [Abstract] [Full Text] [Related]

  • 5. Halofantrine metabolism in microsomes in man: major role of CYP 3A4 and CYP 3A5.
    Baune B, Flinois JP, Furlan V, Gimenez F, Taburet AM, Becquemont L, Farinotti R.
    J Pharm Pharmacol; 1999 Apr; 51(4):419-26. PubMed ID: 10385214
    [Abstract] [Full Text] [Related]

  • 6. Microsomal binding of amitriptyline: effect on estimation of enzyme kinetic parameters in vitro.
    Venkatakrishnan K, von Moltke LL, Obach RS, Greenblatt DJ.
    J Pharmacol Exp Ther; 2000 May; 293(2):343-50. PubMed ID: 10773001
    [Abstract] [Full Text] [Related]

  • 7. Cytochromes P450 mediating the N-demethylation of amitriptyline.
    Ghahramani P, Ellis SW, Lennard MS, Ramsay LE, Tucker GT.
    Br J Clin Pharmacol; 1997 Feb; 43(2):137-44. PubMed ID: 9131945
    [Abstract] [Full Text] [Related]

  • 8. Metabolism of the tricyclic antidepressant amitriptyline by cDNA-expressed human cytochrome P450 enzymes.
    Olesen OV, Linnet K.
    Pharmacology; 1997 Nov; 55(5):235-43. PubMed ID: 9399333
    [Abstract] [Full Text] [Related]

  • 9. Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: role of CYP2C9, CYP2C19, CYP2D6, and CYP3A.
    von Moltke LL, Greenblatt DJ, Grassi JM, Granda BW, Venkatakrishnan K, Schmider J, Harmatz JS, Shader RI.
    J Pharm Pharmacol; 1998 Sep; 50(9):997-1004. PubMed ID: 9811160
    [Abstract] [Full Text] [Related]

  • 10. Nortriptyline E-10-hydroxylation in vitro is mediated by human CYP2D6 (high affinity) and CYP3A4 (low affinity): implications for interactions with enzyme-inducing drugs.
    Venkatakrishnan K, von Moltke LL, Greenblatt DJ.
    J Clin Pharmacol; 1999 Jun; 39(6):567-77. PubMed ID: 10354960
    [Abstract] [Full Text] [Related]

  • 11. Identification of human cytochrome P450 isoforms involved in the metabolism of S-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid.
    Taguchi K, Konishi T, Nishikawa H, Kitamura S.
    Xenobiotica; 1999 Sep; 29(9):899-907. PubMed ID: 10548450
    [Abstract] [Full Text] [Related]

  • 12. Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin.
    Heyn H, White RB, Stevens JC.
    Drug Metab Dispos; 1996 Sep; 24(9):948-54. PubMed ID: 8886603
    [Abstract] [Full Text] [Related]

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  • 14. Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate.
    Venkatakrishnan K, von Moltke LL, Greenblatt DJ.
    J Pharmacol Exp Ther; 2001 Apr; 297(1):326-37. PubMed ID: 11259560
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  • 16. Interaction of human liver cytochromes P450 in vitro with LY307640, a gastric proton pump inhibitor.
    VandenBranden M, Ring BJ, Binkley SN, Wrighton SA.
    Pharmacogenetics; 1996 Feb; 6(1):81-91. PubMed ID: 8845864
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  • 18. Relative contribution of CYP3A to amitriptyline clearance in humans: in vitro and in vivo studies.
    Venkatakrishnan K, Schmider J, Harmatz JS, Ehrenberg BL, von Moltke LL, Graf JA, Mertzanis P, Corbett KE, Rodriguez MC, Shader RI, Greenblatt DJ.
    J Clin Pharmacol; 2001 Oct; 41(10):1043-54. PubMed ID: 11583471
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