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Journal Abstract Search

219 related items for PubMed ID: 9578576

  • 1. Dual inhibition of human type 4 phosphodiesterase isostates by (R, R)-(+/-)-methyl 3-acetyl-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-3- methyl-1-pyrrolidinecarboxylate.
    Tian G, Rocque WJ, Wiseman JS, Thompson IZ, Holmes WD, Domanico PL, Stafford JA, Feldman PL, Luther MA.
    Biochemistry; 1998 May 12; 37(19):6894-904. PubMed ID: 9578576
    [Abstract] [Full Text] [Related]

  • 2. Human recombinant phosphodiesterase 4B2B binds (R)-rolipram at a single site with two affinities.
    Rocque WJ, Tian G, Wiseman JS, Holmes WD, Zajac-Thompson I, Willard DH, Patel IR, Wisely GB, Clay WC, Kadwell SH, Hoffman CR, Luther MA.
    Biochemistry; 1997 Nov 18; 36(46):14250-61. PubMed ID: 9369498
    [Abstract] [Full Text] [Related]

  • 3. CDP840: a novel inhibitor of PDE-4.
    Perry MJ, O'Connell J, Walker C, Crabbe T, Baldock D, Russell A, Lumb S, Huang Z, Howat D, Allen R, Merriman M, Walls J, Daniel T, Hughes B, Laliberte F, Higgs GA, Owens RJ.
    Cell Biochem Biophys; 1998 Nov 18; 29(1-2):113-32. PubMed ID: 9631241
    [Abstract] [Full Text] [Related]

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  • 5. Mapping the functional domains of human recombinant phosphodiesterase 4A: structural requirements for catalytic activity and rolipram binding.
    Jacobitz S, McLaughlin MM, Livi GP, Burman M, Torphy TJ.
    Mol Pharmacol; 1996 Oct 18; 50(4):891-9. PubMed ID: 8863835
    [Abstract] [Full Text] [Related]

  • 6. Functional and biochemical evidence for diazepam as a cyclic nucleotide phosphodiesterase type 4 inhibitor.
    Collado MC, Beleta J, Martinez E, Miralpeix M, Domènech T, Palacios JM, Hernández J.
    Br J Pharmacol; 1998 Mar 18; 123(6):1047-54. PubMed ID: 9559885
    [Abstract] [Full Text] [Related]

  • 7. Inhibitors of phosphodiesterase IV (PDE IV) increase acid secretion in rabbit isolated gastric glands: correlation between function and interaction with a high-affinity rolipram binding site.
    Barnette MS, Grous M, Cieslinski LB, Burman M, Christensen SB, Torphy TJ.
    J Pharmacol Exp Ther; 1995 Jun 18; 273(3):1396-402. PubMed ID: 7791113
    [Abstract] [Full Text] [Related]

  • 8. Characterization of CHO-K1 cells stably expressing PDE-IV enzymes. Whole-cell cAMP determinations vs broken-cell enzymatic assays.
    Pon DJ, Plant M, Tkach J, Boulet L, Muise E, Allen RA, Rodger IW.
    Cell Biochem Biophys; 1998 Jun 18; 29(1-2):159-78. PubMed ID: 9631244
    [Abstract] [Full Text] [Related]

  • 9. Biarylcarboxylic acids and -amides: inhibition of phosphodiesterase type IV versus [3H]rolipram binding activity and their relationship to emetic behavior in the ferret.
    Duplantier AJ, Biggers MS, Chambers RJ, Cheng JB, Cooper K, Damon DB, Eggler JF, Kraus KG, Marfat A, Masamune H, Pillar JS, Shirley JT, Umland JP, Watson JW.
    J Med Chem; 1996 Jan 05; 39(1):120-5. PubMed ID: 8568798
    [Abstract] [Full Text] [Related]

  • 10. Characterization of phosphodiesterase 4 in guinea-pig macrophages: multiple activities, association states and sensitivity to selective inhibitors.
    Kelly JJ, Barnes PJ, Giembycz MA.
    Br J Pharmacol; 1998 May 05; 124(1):129-40. PubMed ID: 9630352
    [Abstract] [Full Text] [Related]

  • 11. Role of low Km cyclic AMP phosphodiesterase inhibition in tracheal relaxation and bronchodilation in the guinea pig.
    Harris AL, Connell MJ, Ferguson EW, Wallace AM, Gordon RJ, Pagani ED, Silver PJ.
    J Pharmacol Exp Ther; 1989 Oct 05; 251(1):199-206. PubMed ID: 2552074
    [Abstract] [Full Text] [Related]

  • 12. Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram.
    Zhao Y, Zhang HT, O'Donnell JM.
    J Pharmacol Exp Ther; 2003 May 05; 305(2):565-72. PubMed ID: 12704225
    [Abstract] [Full Text] [Related]

  • 13. The ability of phosphodiesterase IV inhibitors to suppress superoxide production in guinea pig eosinophils is correlated with inhibition of phosphodiesterase IV catalytic activity.
    Barnette MS, Manning CD, Cieslinski LB, Burman M, Christensen SB, Torphy TJ.
    J Pharmacol Exp Ther; 1995 May 05; 273(2):674-9. PubMed ID: 7752069
    [Abstract] [Full Text] [Related]

  • 14. Airway relaxant and anti-inflammatory properties of a PDE4 inhibitor with low affinity for the high-affinity rolipram binding site.
    Martin C, Göggel R, Dal Piaz V, Vergelli C, Giovannoni P, Ernst M, Uhlig S.
    Naunyn Schmiedebergs Arch Pharmacol; 2002 Apr 05; 365(4):284-9. PubMed ID: 11919652
    [Abstract] [Full Text] [Related]

  • 15. Introduction of a conformational switching element on a pyrrolidine ring. Synthesis and evaluation of (R*,R*)-(+/-)-methyl 3-acetyl-4-[3- (cyclopentyloxy)-4-methoxyphenyl]-3-methyl-1-pyrrolidinecarboxylate, a potent and selective inhibitor of cAMP-specific phosphodiesterase.
    Stafford JA, Veal JM, Feldman PL, Valvano NL, Baer PG, Brackeen MF, Brawley ES, Connolly KM, Domanico PL, Han B.
    J Med Chem; 1995 Dec 22; 38(26):4972-5. PubMed ID: 8544172
    [No Abstract] [Full Text] [Related]

  • 16. Coexpression of human cAMP-specific phosphodiesterase activity and high affinity rolipram binding in yeast.
    Torphy TJ, Stadel JM, Burman M, Cieslinski LB, McLaughlin MM, White JR, Livi GP.
    J Biol Chem; 1992 Jan 25; 267(3):1798-804. PubMed ID: 1309798
    [Abstract] [Full Text] [Related]

  • 17. Expression and characterization of deletion recombinants of two cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE-3).
    He R, Komas N, Ekholm D, Murata T, Taira M, Hockman S, Degerman E, Manganiello VC.
    Cell Biochem Biophys; 1998 Jan 25; 29(1-2):89-111. PubMed ID: 9631240
    [Abstract] [Full Text] [Related]

  • 18. Identification, characterization, and functional role of phosphodiesterase type IV in cerebral vessels: effects of selective phosphodiesterase inhibitors.
    Willette RN, Shiloh AO, Sauermelch CF, Sulpizio A, Michell MP, Cieslinski LB, Torphy TJ, Ohlstein EH.
    J Cereb Blood Flow Metab; 1997 Feb 25; 17(2):210-9. PubMed ID: 9040501
    [Abstract] [Full Text] [Related]

  • 19. Modulation of cell adhesion molecule expression and function on human lung microvascular endothelial cells by inhibition of phosphodiesterases 3 and 4.
    Blease K, Burke-Gaffney A, Hellewell PG.
    Br J Pharmacol; 1998 May 25; 124(1):229-37. PubMed ID: 9630364
    [Abstract] [Full Text] [Related]

  • 20. Behaviour of [11C]R(-)- and [11C]S(+)-rolipram in vitro and in vivo, and their use as PET radiotracers for the quantificative assay of PDE4.
    Parker CA, Matthews JC, Gunn RN, Martarello L, Cunningham VJ, Dommett D, Knibb ST, Bender D, Jakobsen S, Brown J, Gee AD.
    Synapse; 2005 Mar 15; 55(4):270-9. PubMed ID: 15668983
    [Abstract] [Full Text] [Related]

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