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308 related items for PubMed ID: 9614221

  • 1. Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production.
    Keller JN, Guo Q, Holtsberg FW, Bruce-Keller AJ, Mattson MP.
    J Neurosci; 1998 Jun 15; 18(12):4439-50. PubMed ID: 9614221
    [Abstract] [Full Text] [Related]

  • 2. Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.
    Guo Q, Sopher BL, Furukawa K, Pham DG, Robinson N, Martin GM, Mattson MP.
    J Neurosci; 1997 Jun 01; 17(11):4212-22. PubMed ID: 9151738
    [Abstract] [Full Text] [Related]

  • 3. Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis.
    Guo Q, Robinson N, Mattson MP.
    J Biol Chem; 1998 May 15; 273(20):12341-51. PubMed ID: 9575187
    [Abstract] [Full Text] [Related]

  • 4. Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12.
    Chan SL, Culmsee C, Haughey N, Klapper W, Mattson MP.
    Neurobiol Dis; 2002 Oct 15; 11(1):2-19. PubMed ID: 12460542
    [Abstract] [Full Text] [Related]

  • 5. Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide.
    Guo Q, Furukawa K, Sopher BL, Pham DG, Xie J, Robinson N, Martin GM, Mattson MP.
    Neuroreport; 1996 Dec 20; 8(1):379-83. PubMed ID: 9051814
    [Abstract] [Full Text] [Related]

  • 6. Superoxide mediates the cell-death-enhancing action of presenilin-1 mutations.
    Guo Q, Fu W, Holtsberg FW, Steiner SM, Mattson MP.
    J Neurosci Res; 1999 Jun 01; 56(5):457-70. PubMed ID: 10369213
    [Abstract] [Full Text] [Related]

  • 7. Presenilin-1 mutation alters NGF-induced neurite outgrowth, calcium homeostasis, and transcription factor (AP-1) activation in PC12 cells.
    Furukawa K, Guo Q, Schellenberg GD, Mattson MP.
    J Neurosci Res; 1998 Jun 01; 52(5):618-24. PubMed ID: 9632318
    [Abstract] [Full Text] [Related]

  • 8. Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function.
    Guo Q, Christakos S, Robinson N, Mattson MP.
    Proc Natl Acad Sci U S A; 1998 Mar 17; 95(6):3227-32. PubMed ID: 9501245
    [Abstract] [Full Text] [Related]

  • 9. HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress.
    Kruman II, Nath A, Mattson MP.
    Exp Neurol; 1998 Dec 17; 154(2):276-88. PubMed ID: 9878167
    [Abstract] [Full Text] [Related]

  • 10. Estrogens stabilize mitochondrial function and protect neural cells against the pro-apoptotic action of mutant presenilin-1.
    Mattson MP, Robinson N, Guo Q.
    Neuroreport; 1997 Dec 01; 8(17):3817-21. PubMed ID: 9427376
    [Abstract] [Full Text] [Related]

  • 11. Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease.
    Mattson MP, Guo Q, Furukawa K, Pedersen WA.
    J Neurochem; 1998 Jan 01; 70(1):1-14. PubMed ID: 9422341
    [Abstract] [Full Text] [Related]

  • 12. Endoplasmic reticulum stress-induced cysteine protease activation in cortical neurons: effect of an Alzheimer's disease-linked presenilin-1 knock-in mutation.
    Siman R, Flood DG, Thinakaran G, Neumar RW.
    J Biol Chem; 2001 Nov 30; 276(48):44736-43. PubMed ID: 11574534
    [Abstract] [Full Text] [Related]

  • 13. Pivotal role of mitochondrial calcium uptake in neural cell apoptosis and necrosis.
    Kruman II, Mattson MP.
    J Neurochem; 1999 Feb 30; 72(2):529-40. PubMed ID: 9930724
    [Abstract] [Full Text] [Related]

  • 14. The mechanisms of neuronal death produced by mitochondrial toxin 3-nitropropionic acid: the roles of N-methyl-D-aspartate glutamate receptors and mitochondrial calcium overload.
    Lee WT, Yin HS, Shen YZ.
    Neuroscience; 2002 Feb 30; 112(3):707-16. PubMed ID: 12074912
    [Abstract] [Full Text] [Related]

  • 15. Aberrant induction of Par-4 is involved in apoptosis of hippocampal neurons in presenilin-1 M146V mutant knock-in mice.
    Xie J, Chang X, Zhang X, Guo Q.
    Brain Res; 2001 Oct 05; 915(1):1-10. PubMed ID: 11578614
    [Abstract] [Full Text] [Related]

  • 16. Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis.
    Mattson MP, Zhu H, Yu J, Kindy MS.
    J Neurosci; 2000 Feb 15; 20(4):1358-64. PubMed ID: 10662826
    [Abstract] [Full Text] [Related]

  • 17. A presenilin-1 mutation renders neurons vulnerable to isoflurane toxicity.
    Liang G, Wang Q, Li Y, Kang B, Eckenhoff MF, Eckenhoff RG, Wei H.
    Anesth Analg; 2008 Feb 15; 106(2):492-500, table of contents. PubMed ID: 18227305
    [Abstract] [Full Text] [Related]

  • 18. Cell and molecular neurobiology of presenilins: a role for the endoplasmic reticulum in the pathogenesis of Alzheimer's disease?
    Mattson MP, Guo Q.
    J Neurosci Res; 1997 Nov 15; 50(4):505-13. PubMed ID: 9404712
    [Abstract] [Full Text] [Related]

  • 19. Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: evidence for a mitochondrial pathway independent of the permeability transition.
    Rodrigues CM, Stieers CL, Keene CD, Ma X, Kren BT, Low WC, Steer CJ.
    J Neurochem; 2000 Dec 15; 75(6):2368-79. PubMed ID: 11080188
    [Abstract] [Full Text] [Related]

  • 20. Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice.
    Begley JG, Duan W, Chan S, Duff K, Mattson MP.
    J Neurochem; 1999 Mar 15; 72(3):1030-9. PubMed ID: 10037474
    [Abstract] [Full Text] [Related]

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