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396 related items for PubMed ID: 9614564

  • 1. Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells.
    Balzarini J, Degrève B, Andrei G, Neyts J, Sandvold M, Myhren F, de Clercq E.
    Gene Ther; 1998 Mar; 5(3):419-26. PubMed ID: 9614564
    [Abstract] [Full Text] [Related]

  • 2. Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase gene-transfected tumor cells.
    Balzarini J, Bohman C, Walker RT, de Clercq E.
    Mol Pharmacol; 1994 Jun; 45(6):1253-8. PubMed ID: 8022417
    [Abstract] [Full Text] [Related]

  • 3. Selection of HSV-1 TK gene-transfected murine mammary carcinoma cells resistant to (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and ganciclovir (GCV).
    Degrève B, De Clercq E, Balzarini J.
    Gene Ther; 2000 Sep; 7(18):1543-52. PubMed ID: 11021592
    [Abstract] [Full Text] [Related]

  • 4. Novel (E)-5-(2-iodovinyl)-2'-deoxyuridine derivatives as potential cytostatic agents against herpes simplex virus thymidine kinase gene transfected tumors.
    Balzarini J, Morin KW, Knaus EE, Wiebe LI, De Clercq E.
    Gene Ther; 1995 Jul; 2(5):317-22. PubMed ID: 7671107
    [Abstract] [Full Text] [Related]

  • 5. Transduction of human pancreatic tumor cells with vesicular stomatitis virus G-pseudotyped retroviral vectors containing a herpes simplex virus thymidine kinase mutant gene enhances bystander effects and sensitivity to ganciclovir.
    Howard BD, Boenicke L, Schniewind B, Henne-Bruns D, Kalthoff H.
    Cancer Gene Ther; 2000 Jun; 7(6):927-38. PubMed ID: 10880025
    [Abstract] [Full Text] [Related]

  • 6. Potentiation of ganciclovir toxicity in the herpes simplex virus thymidine kinase/ganciclovir administration system by ponicidin.
    Hayashi K, Hayashi T, Sun HD, Takeda Y.
    Cancer Gene Ther; 2000 Jan; 7(1):45-52. PubMed ID: 10678355
    [Abstract] [Full Text] [Related]

  • 7. Tumor-specific in vivo transfection with HSV-1 thymidine kinase gene using a Sindbis viral vector as a basis for prodrug ganciclovir activation and PET.
    Tseng JC, Zanzonico PB, Levin B, Finn R, Larson SM, Meruelo D.
    J Nucl Med; 2006 Jul; 47(7):1136-43. PubMed ID: 16818948
    [Abstract] [Full Text] [Related]

  • 8. Molecular imaging with 123I-FIAU, 18F-FUdR, 18F-FET, and 18F-FDG for monitoring herpes simplex virus type 1 thymidine kinase and ganciclovir prodrug activation gene therapy of cancer.
    Wang HE, Yu HM, Liu RS, Lin M, Gelovani JG, Hwang JJ, Wei HJ, Deng WP.
    J Nucl Med; 2006 Jul; 47(7):1161-71. PubMed ID: 16818951
    [Abstract] [Full Text] [Related]

  • 9. Adenovirus-mediated gene transfer of enhanced Herpes simplex virus thymidine kinase mutants improves prodrug-mediated tumor cell killing.
    Wiewrodt R, Amin K, Kiefer M, Jovanovic VP, Kapoor V, Force S, Chang M, Lanuti M, Black ME, Kaiser LR, Albelda SM.
    Cancer Gene Ther; 2003 May; 10(5):353-64. PubMed ID: 12719705
    [Abstract] [Full Text] [Related]

  • 10. Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene.
    Balzarini J, De Clercq E, Verbruggen A, Ayusawa D, Shimizu K, Seno T.
    Mol Pharmacol; 1987 Sep; 32(3):410-6. PubMed ID: 2823092
    [Abstract] [Full Text] [Related]

  • 11. Pronounced cytostatic activity and bystander effect of a novel series of fluorescent tricyclic acyclovir and ganciclovir derivatives in herpes simplex virus thymidine kinase gene-transduced tumor cell lines.
    Balzarini J, Ostrowski T, Goslinski T, De Clercq E, Golankiewicz B.
    Gene Ther; 2002 Sep; 9(17):1173-82. PubMed ID: 12170381
    [Abstract] [Full Text] [Related]

  • 12. The role of a HSV thymidine kinase stimulating substance, scopadulciol, in improving the efficacy of cancer gene therapy.
    Hayashi K, Lee JB, Maitani Y, Toyooka N, Nemoto H, Hayashi T.
    J Gene Med; 2006 Aug; 8(8):1056-67. PubMed ID: 16779868
    [Abstract] [Full Text] [Related]

  • 13. Killing effects of ganciclovir on human pulmonary adenocarcinoma cell A549 transduced with HSV1-TK gene in vitro and in vivo.
    He XL, Guo XJ, Qian GS, He XH, Huang GJ, Chen WZ, Li SP.
    Acta Pharmacol Sin; 2001 Oct; 22(10):901-6. PubMed ID: 11749772
    [Abstract] [Full Text] [Related]

  • 14. The role of the E1B 55 kDa gene product in oncolytic adenoviral vectors expressing herpes simplex virus-tk: assessment of antitumor efficacy and toxicity.
    Wildner O, Morris JC.
    Cancer Res; 2000 Aug 01; 60(15):4167-74. PubMed ID: 10945625
    [Abstract] [Full Text] [Related]

  • 15. [Bystander effect mediated by herpes simplex virus-thymidine kinase/ganciclovir approach on prostatic cancer cells and its regulation].
    Xing Y, Lu G, Xiao Y, Zeng F, Zhang Q, Xiong P, Feng W.
    Zhonghua Yi Xue Za Zhi; 2002 Nov 10; 82(21):1484-7. PubMed ID: 12509912
    [Abstract] [Full Text] [Related]

  • 16. Evaluation of ganciclovir-mediated enhancement of the antitumoral effect in oncolytic, multimutated herpes simplex virus type 1 (G207) therapy of brain tumors.
    Todo T, Rabkin SD, Martuza RL.
    Cancer Gene Ther; 2000 Jun 10; 7(6):939-46. PubMed ID: 10880026
    [Abstract] [Full Text] [Related]

  • 17. Suppression of murine mammary carcinoma growth and metastasis by HSVtk/GCV gene therapy using in vivo electroporation.
    Shibata MA, Morimoto J, Otsuki Y.
    Cancer Gene Ther; 2002 Jan 10; 9(1):16-27. PubMed ID: 11916241
    [Abstract] [Full Text] [Related]

  • 18. Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 thymidine kinase gene.
    Balzarini J, De Clercq E, Verbruggen A, Ayusawa D, Seno T.
    Mol Pharmacol; 1985 Dec 10; 28(6):581-7. PubMed ID: 3001499
    [Abstract] [Full Text] [Related]

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  • 20. Purified herpes simplex virus thymidine kinase retroviral particles: III. Characterization of bystander killing mechanisms in transfected tumor cells.
    Burrows FJ, Gore M, Smiley WR, Kanemitsu MY, Jolly DJ, Read SB, Nicholas T, Kruse CA.
    Cancer Gene Ther; 2002 Jan 10; 9(1):87-95. PubMed ID: 11916247
    [Abstract] [Full Text] [Related]

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