These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

358 related items for PubMed ID: 9639575

  • 1. Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan.
    Büttner FH, Hughes CE, Margerie D, Lichte A, Tschesche H, Caterson B, Bartnik E.
    Biochem J; 1998 Jul 01; 333 ( Pt 1)(Pt 1):159-65. PubMed ID: 9639575
    [Abstract] [Full Text] [Related]

  • 2. Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro.
    Hughes CE, Caterson B, Fosang AJ, Roughley PJ, Mort JS.
    Biochem J; 1995 Feb 01; 305 ( Pt 3)(Pt 3):799-804. PubMed ID: 7531436
    [Abstract] [Full Text] [Related]

  • 3. Truncation of the amino-terminus of the recombinant aggrecan rAgg1mut leads to reduced cleavage at the aggrecanase site. Efficient aggrecanase catabolism may depend on multiple substrate interactions.
    Hörber C, Büttner FH, Kern C, Schmiedeknecht G, Bartnik E.
    Matrix Biol; 2000 Nov 01; 19(6):533-43. PubMed ID: 11068207
    [Abstract] [Full Text] [Related]

  • 4. Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.
    Little CB, Flannery CR, Hughes CE, Mort JS, Roughley PJ, Dent C, Caterson B.
    Biochem J; 1999 Nov 15; 344 Pt 1(Pt 1):61-8. PubMed ID: 10548534
    [Abstract] [Full Text] [Related]

  • 5. The interglobular domain of cartilage aggrecan is cleaved by hemorrhagic metalloproteinase HT-d (atrolysin C) at the matrix metalloproteinase and aggrecanase sites.
    Tortorella MD, Pratta MA, Fox JW, Arner EC.
    J Biol Chem; 1998 Mar 06; 273(10):5846-50. PubMed ID: 9488721
    [Abstract] [Full Text] [Related]

  • 6. Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain.
    Lark MW, Gordy JT, Weidner JR, Ayala J, Kimura JH, Williams HR, Mumford RA, Flannery CR, Carlson SS, Iwata M.
    J Biol Chem; 1995 Feb 10; 270(6):2550-6. PubMed ID: 7852317
    [Abstract] [Full Text] [Related]

  • 7. Mutations in the interglobular domain of aggrecan alter matrix metalloproteinase and aggrecanase cleavage patterns. Evidence that matrix metalloproteinase cleavage interferes with aggrecanase activity.
    Mercuri FA, Maciewicz RA, Tart J, Last K, Fosang AJ.
    J Biol Chem; 2000 Oct 20; 275(42):33038-45. PubMed ID: 11032846
    [Abstract] [Full Text] [Related]

  • 8. Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan.
    Fosang AJ, Last K, Neame PJ, Murphy G, Knäuper V, Tschesche H, Hughes CE, Caterson B, Hardingham TE.
    Biochem J; 1994 Dec 01; 304 ( Pt 2)(Pt 2):347-51. PubMed ID: 7998967
    [Abstract] [Full Text] [Related]

  • 9. Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase.
    Arner EC, Hughes CE, Decicco CP, Caterson B, Tortorella MD.
    Osteoarthritis Cartilage; 1998 May 01; 6(3):214-28. PubMed ID: 9682788
    [Abstract] [Full Text] [Related]

  • 10. Aggrecanase and metalloproteinase-specific aggrecan neo-epitopes are induced in the articular cartilage of mice with collagen II-induced arthritis.
    Singer II, Scott S, Kawka DW, Bayne EK, Weidner JR, Williams HR, Mumford RA, Lark MW, McDonnell J, Christen AJ, Moore VL, Mudgett JS, Visco DM.
    Osteoarthritis Cartilage; 1997 Nov 01; 5(6):407-18. PubMed ID: 9536289
    [Abstract] [Full Text] [Related]

  • 11. Cleavage of native cartilage aggrecan by neutrophil collagenase (MMP-8) is distinct from endogenous cleavage by aggrecanase.
    Arner EC, Decicco CP, Cherney R, Tortorella MD.
    J Biol Chem; 1997 Apr 04; 272(14):9294-9. PubMed ID: 9083065
    [Abstract] [Full Text] [Related]

  • 12. Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase.
    Mercuri FA, Doege KJ, Arner EC, Pratta MA, Last K, Fosang AJ.
    J Biol Chem; 1999 Nov 05; 274(45):32387-95. PubMed ID: 10542281
    [Abstract] [Full Text] [Related]

  • 13. Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain.
    Fosang AJ, Last K, Fujii Y, Seiki M, Okada Y.
    FEBS Lett; 1998 Jul 03; 430(3):186-90. PubMed ID: 9688535
    [Abstract] [Full Text] [Related]

  • 14. Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation.
    Little CB, Hughes CE, Curtis CL, Janusz MJ, Bohne R, Wang-Weigand S, Taiwo YO, Mitchell PG, Otterness IG, Flannery CR, Caterson B.
    Matrix Biol; 2002 Apr 03; 21(3):271-88. PubMed ID: 12009333
    [Abstract] [Full Text] [Related]

  • 15. Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.
    Lark MW, Bayne EK, Flanagan J, Harper CF, Hoerrner LA, Hutchinson NI, Singer II, Donatelli SA, Weidner JR, Williams HR, Mumford RA, Lohmander LS.
    J Clin Invest; 1997 Jul 01; 100(1):93-106. PubMed ID: 9202061
    [Abstract] [Full Text] [Related]

  • 16. Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.
    Fosang AJ, Last K, Maciewicz RA.
    J Clin Invest; 1996 Nov 15; 98(10):2292-9. PubMed ID: 8941646
    [Abstract] [Full Text] [Related]

  • 17. The 45 kDa collagen-binding fragment of fibronectin induces matrix metalloproteinase-13 synthesis by chondrocytes and aggrecan degradation by aggrecanases.
    Stanton H, Ung L, Fosang AJ.
    Biochem J; 2002 May 15; 364(Pt 1):181-90. PubMed ID: 11988091
    [Abstract] [Full Text] [Related]

  • 18. The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.
    Fosang AJ, Neame PJ, Last K, Hardingham TE, Murphy G, Hamilton JA.
    J Biol Chem; 1992 Sep 25; 267(27):19470-4. PubMed ID: 1326552
    [Abstract] [Full Text] [Related]

  • 19. Degradation of cartilage aggrecan by collagenase-3 (MMP-13).
    Fosang AJ, Last K, Knäuper V, Murphy G, Neame PJ.
    FEBS Lett; 1996 Feb 12; 380(1-2):17-20. PubMed ID: 8603731
    [Abstract] [Full Text] [Related]

  • 20.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

    Page: [Next] [New Search]
    of 18.