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467 related items for PubMed ID: 9651158

  • 1. Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423) at wild type and recombinant GABAA receptors.
    Cox ED, Diaz-Arauzo H, Huang Q, Reddy MS, Ma C, Harris B, McKernan R, Skolnick P, Cook JM.
    J Med Chem; 1998 Jul 02; 41(14):2537-52. PubMed ID: 9651158
    [Abstract] [Full Text] [Related]

  • 2. Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogues of 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester.
    Hollinshead SP, Trudell ML, Skolnick P, Cook JM.
    J Med Chem; 1990 Mar 02; 33(3):1062-9. PubMed ID: 1968513
    [Abstract] [Full Text] [Related]

  • 3. Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality.
    Jacobsen EJ, Stelzer LS, TenBrink RE, Belonga KL, Carter DB, Im HK, Im WB, Sethy VH, Tang AH, VonVoigtlander PF, Petke JD, Zhong WZ, Mickelson JW.
    J Med Chem; 1999 Apr 08; 42(7):1123-44. PubMed ID: 10197957
    [Abstract] [Full Text] [Related]

  • 4. Benzodiazepine receptor ligands. 8: synthesis and pharmacological evaluation of new pyrazolo[5,1-c] [1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: high affinity ligands endowed with inverse-agonist pharmacological efficacy.
    Guerrini G, Costanzo A, Ciciani G, Bruni F, Selleri S, Costagli C, Besnard F, Costa B, Martini C, De Siena G, Malmberg-Aiello P.
    Bioorg Med Chem; 2006 Feb 01; 14(3):758-75. PubMed ID: 16214350
    [Abstract] [Full Text] [Related]

  • 5. Quantitative structure-activity relationship study of some benzodiazepine-receptor ligands having inverse agonist/antagonist and agonist actions.
    Sharma RC, Ojha TN, Tiwari S, Singh P.
    Drug Des Discov; 1992 Feb 01; 9(2):135-43. PubMed ID: 1338366
    [Abstract] [Full Text] [Related]

  • 6. Studies of molecular pharmacophore/receptor models for GABAA/benzodiazepine receptor subtypes: binding affinities of substituted beta-carbolines at recombinant alpha x beta 3 gamma 2 subtypes and quantitative structure-activity relationship studies via a comparative molecular field analysis.
    Huang Q, Cox ED, Gan T, Ma C, Bennett DW, McKernan RM, Cook JM.
    Drug Des Discov; 1999 Jul 01; 16(1):55-76. PubMed ID: 10466057
    [Abstract] [Full Text] [Related]

  • 7. A novel selective GABA(A) alpha1 receptor agonist displaying sedative and anxiolytic-like properties in rodents.
    Selleri S, Bruni F, Costagli C, Costanzo A, Guerrini G, Ciciani G, Gratteri P, Besnard F, Costa B, Montali M, Martini C, Fohlin J, De Siena G, Aiello PM.
    J Med Chem; 2005 Oct 20; 48(21):6756-60. PubMed ID: 16220991
    [Abstract] [Full Text] [Related]

  • 8. Functional comparison of the role of gamma subunits in recombinant human gamma-aminobutyric acidA/benzodiazepine receptors.
    Wafford KA, Bain CJ, Whiting PJ, Kemp JA.
    Mol Pharmacol; 1993 Aug 20; 44(2):437-42. PubMed ID: 8102787
    [Abstract] [Full Text] [Related]

  • 9. gamma-Aminobutyrate-A receptor modulation by 3-aryl-1-(arylsulfonyl)- 1,4,5,6-tetrahydropyridazines.
    Rybczynski PJ, Combs DW, Jacobs K, Shank RP, Dubinsky B.
    J Med Chem; 1999 Jul 01; 42(13):2403-8. PubMed ID: 10395481
    [Abstract] [Full Text] [Related]

  • 10. Anticonvulsant action of the beta-carboline abecarnil: studies in rodents and baboon, Papio papio.
    Turski L, Stephens DN, Jensen LH, Petersen EN, Meldrum BS, Patel S, Hansen JB, Löscher W, Schneider HH, Schmiechen R.
    J Pharmacol Exp Ther; 1990 Apr 01; 253(1):344-52. PubMed ID: 1970362
    [Abstract] [Full Text] [Related]

  • 11. Benzodiazepine receptor ligands. 4. Synthesis and pharmacological evaluation of 3-heteroaryl-8-chloropyrazolo[5,1-c][1,2,4] benzotriazine 5-oxides.
    Costanzo A, Guerrini G, Ciciani G, Bruni F, Selleri S, Costa B, Martini C, Lucacchini A, Aiello PM, Ipponi A.
    J Med Chem; 1999 Jun 17; 42(12):2218-26. PubMed ID: 10377227
    [Abstract] [Full Text] [Related]

  • 12. Pharmacokinetics, anticonvulsant efficacy and adverse effects of the beta-carboline abecarnil, a novel ligand for benzodiazepine receptors, after acute and chronic administration in dogs.
    Löscher W, Hönack D, Scherkl R, Hashem A, Frey HH.
    J Pharmacol Exp Ther; 1990 Nov 17; 255(2):541-8. PubMed ID: 1978730
    [Abstract] [Full Text] [Related]

  • 13. 3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1.
    Carling RW, Moore KW, Street LJ, Wild D, Isted C, Leeson PD, Thomas S, O'Connor D, McKernan RM, Quirk K, Cook SM, Atack JR, Wafford KA, Thompson SA, Dawson GR, Ferris P, Castro JL.
    J Med Chem; 2004 Mar 25; 47(7):1807-22. PubMed ID: 15027873
    [Abstract] [Full Text] [Related]

  • 14. Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore.
    Allen MS, Hagen TJ, Trudell ML, Codding PW, Skolnick P, Cook JM.
    J Med Chem; 1988 Sep 25; 31(9):1854-61. PubMed ID: 2842507
    [Abstract] [Full Text] [Related]

  • 15. Pharmacological modulation of the diazepam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2.
    Knoflach F, Benke D, Wang Y, Scheurer L, Lüddens H, Hamilton BJ, Carter DB, Mohler H, Benson JA.
    Mol Pharmacol; 1996 Nov 25; 50(5):1253-61. PubMed ID: 8913357
    [Abstract] [Full Text] [Related]

  • 16. 5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists.
    Madsen C, Jensen AA, Liljefors T, Kristiansen U, Nielsen B, Hansen CP, Larsen M, Ebert B, Bang-Andersen B, Krogsgaard-Larsen P, Frølund B.
    J Med Chem; 2007 Aug 23; 50(17):4147-61. PubMed ID: 17655213
    [Abstract] [Full Text] [Related]

  • 17. Novel 3-iodo-8-ethoxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide as promising lead for design of alpha5-inverse agonist useful tools for therapy of mnemonic damage.
    Guerrini G, Ciciani G, Cambi G, Bruni F, Selleri S, Besnard F, Montali M, Martini C, Ghelardini C, Galeotti N, Costanzo A.
    Bioorg Med Chem; 2007 Apr 01; 15(7):2573-86. PubMed ID: 17306981
    [Abstract] [Full Text] [Related]

  • 18. Molecular and neurochemical evaluation of the effects of etizolam on GABAA receptors under normal and stress conditions.
    Sanna E, Pau D, Tuveri F, Massa F, Maciocco E, Acquas C, Floris C, Fontana SN, Maira G, Biggio G.
    Arzneimittelforschung; 1999 Feb 01; 49(2):88-95. PubMed ID: 10083975
    [Abstract] [Full Text] [Related]

  • 19. Dual mode of stimulation by the beta-carboline ZK 91085 of recombinant GABA(A) receptor currents: molecular determinants affecting its action.
    Thomet U, Baur R, Scholze P, Sieghart W, Sigel E.
    Br J Pharmacol; 1999 Jul 01; 127(5):1231-9. PubMed ID: 10455270
    [Abstract] [Full Text] [Related]

  • 20. Contribution of GABAA receptor subtypes to the anxiolytic-like, motor, and discriminative stimulus effects of benzodiazepines: studies with the functionally selective ligand SL651498 [6-fluoro-9-methyl-2-phenyl-4-(pyrrolidin-1-yl-carbonyl)-2,9-dihydro-1H-pyridol[3,4-b]indol-1-one].
    Licata SC, Platt DM, Cook JM, Sarma PV, Griebel G, Rowlett JK.
    J Pharmacol Exp Ther; 2005 Jun 01; 313(3):1118-25. PubMed ID: 15687371
    [Abstract] [Full Text] [Related]

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