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284 related items for PubMed ID: 9655946

  • 1. Biosynthesis of 2-aceto-2-hydroxy acids: acetolactate synthases and acetohydroxyacid synthases.
    Chipman D, Barak Z, Schloss JV.
    Biochim Biophys Acta; 1998 Jun 29; 1385(2):401-19. PubMed ID: 9655946
    [Abstract] [Full Text] [Related]

  • 2. Many of the functional differences between acetohydroxyacid synthase (AHAS) isozyme I and other AHASs are a result of the rapid formation and breakdown of the covalent acetolactate-thiamin diphosphate adduct in AHAS I.
    Belenky I, Steinmetz A, Vyazmensky M, Barak Z, Tittmann K, Chipman DM.
    FEBS J; 2012 Jun 29; 279(11):1967-79. PubMed ID: 22443469
    [Abstract] [Full Text] [Related]

  • 3. Binding and activation of thiamin diphosphate in acetohydroxyacid synthase.
    Bar-Ilan A, Balan V, Tittmann K, Golbik R, Vyazmensky M, Hübner G, Barak Z, Chipman DM.
    Biochemistry; 2001 Oct 02; 40(39):11946-54. PubMed ID: 11570896
    [Abstract] [Full Text] [Related]

  • 4. The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate.
    Pang SS, Duggleby RG, Schowen RL, Guddat LW.
    J Biol Chem; 2004 Jan 16; 279(3):2242-53. PubMed ID: 14557277
    [Abstract] [Full Text] [Related]

  • 5. Significant catalytic roles for Glu47 and Gln 110 in all four of the C-C bond-making and -breaking steps of the reactions of acetohydroxyacid synthase II.
    Vyazmensky M, Steinmetz A, Meyer D, Golbik R, Barak Z, Tittmann K, Chipman DM.
    Biochemistry; 2011 Apr 19; 50(15):3250-60. PubMed ID: 21370850
    [Abstract] [Full Text] [Related]

  • 6. Valine 375 and phenylalanine 109 confer affinity and specificity for pyruvate as donor substrate in acetohydroxy acid synthase isozyme II from Escherichia coli.
    Steinmetz A, Vyazmensky M, Meyer D, Barak ZE, Golbik R, Chipman DM, Tittmann K.
    Biochemistry; 2010 Jun 29; 49(25):5188-99. PubMed ID: 20504042
    [Abstract] [Full Text] [Related]

  • 7. Acetohydroxyacid synthase: a target for antimicrobial drug discovery.
    Pue N, Guddat LW.
    Curr Pharm Des; 2014 Jun 29; 20(5):740-53. PubMed ID: 23688082
    [Abstract] [Full Text] [Related]

  • 8. Homology modeling of the structure of bacterial acetohydroxy acid synthase and examination of the active site by site-directed mutagenesis.
    Ibdah M, Bar-Ilan A, Livnah O, Schloss JV, Barak Z, Chipman DM.
    Biochemistry; 1996 Dec 17; 35(50):16282-91. PubMed ID: 8973202
    [Abstract] [Full Text] [Related]

  • 9. Acetohydroxyacid synthases: evolution, structure, and function.
    Liu Y, Li Y, Wang X.
    Appl Microbiol Biotechnol; 2016 Oct 17; 100(20):8633-49. PubMed ID: 27576495
    [Abstract] [Full Text] [Related]

  • 10. Acetohydroxyacid synthase isozyme I from Escherichia coli has unique catalytic and regulatory properties.
    Vinogradov V, Vyazmensky M, Engel S, Belenky I, Kaplun A, Kryukov O, Barak Z, Chipman DM.
    Biochim Biophys Acta; 2006 Mar 17; 1760(3):356-63. PubMed ID: 16326011
    [Abstract] [Full Text] [Related]

  • 11. Electron transfer in acetohydroxy acid synthase as a side reaction of catalysis. Implications for the reactivity and partitioning of the carbanion/enamine form of (alpha-hydroxyethyl)thiamin diphosphate in a "nonredox" flavoenzyme.
    Tittmann K, Schröder K, Golbik R, McCourt J, Kaplun A, Duggleby RG, Barak Z, Chipman DM, Hübner G.
    Biochemistry; 2004 Jul 13; 43(27):8652-61. PubMed ID: 15236573
    [Abstract] [Full Text] [Related]

  • 12. Mutagenesis of Escherichia coli acetohydroxyacid synthase isoenzyme II and characterization of three herbicide-insensitive forms.
    Hill CM, Duggleby RG.
    Biochem J; 1998 Nov 01; 335 ( Pt 3)(Pt 3):653-61. PubMed ID: 9794808
    [Abstract] [Full Text] [Related]

  • 13. Role of a highly conserved proline-126 in ThDP binding of Mycobacterium tuberculosis acetohydroxyacid synthase.
    Baig IA, Gedi V, Lee SC, Koh SH, Yoon MY.
    Enzyme Microb Technol; 2013 Sep 10; 53(4):243-9. PubMed ID: 23931689
    [Abstract] [Full Text] [Related]

  • 14. Crystal structure of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors.
    Pang SS, Duggleby RG, Guddat LW.
    J Mol Biol; 2002 Mar 22; 317(2):249-62. PubMed ID: 11902841
    [Abstract] [Full Text] [Related]

  • 15. Allosteric regulation in Acetohydroxyacid Synthases (AHASs)--different structures and kinetic behavior in isozymes in the same organisms.
    Barak Z, Chipman DM.
    Arch Biochem Biophys; 2012 Mar 15; 519(2):167-74. PubMed ID: 22198286
    [Abstract] [Full Text] [Related]

  • 16. Structure of the regulatory subunit of acetohydroxyacid synthase isozyme III from Escherichia coli.
    Kaplun A, Vyazmensky M, Zherdev Y, Belenky I, Slutzker A, Mendel S, Barak Z, Chipman DM, Shaanan B.
    J Mol Biol; 2006 Mar 31; 357(3):951-63. PubMed ID: 16458324
    [Abstract] [Full Text] [Related]

  • 17. Mechanisms of bacterial acetohydroxyacid synthase (AHAS) and specific inhibitors of Mycobacterium tuberculosis AHAS as potential drug candidates against tuberculosis.
    Gokhale K, Tilak B.
    Curr Drug Targets; 2015 Mar 31; 16(7):689-99. PubMed ID: 25882218
    [Abstract] [Full Text] [Related]

  • 18. Characterization of acetohydroxyacid synthase I from Escherichia coli K-12 and identification of its inhibitors.
    Pham NC, Moon JY, Cho JH, Lee SJ, Park JS, Kim DE, Park Y, Yoon MY.
    Biosci Biotechnol Biochem; 2010 Mar 31; 74(11):2281-6. PubMed ID: 21071847
    [Abstract] [Full Text] [Related]

  • 19. Acetohydroxyacid synthase: a proposed structure for regulatory subunits supported by evidence from mutagenesis.
    Mendel S, Elkayam T, Sella C, Vinogradov V, Vyazmensky M, Chipman DM, Barak Z.
    J Mol Biol; 2001 Mar 16; 307(1):465-77. PubMed ID: 11243831
    [Abstract] [Full Text] [Related]

  • 20. Role of a conserved arginine in the mechanism of acetohydroxyacid synthase: catalysis of condensation with a specific ketoacid substrate.
    Engel S, Vyazmensky M, Vinogradov M, Berkovich D, Bar-Ilan A, Qimron U, Rosiansky Y, Barak Z, Chipman DM.
    J Biol Chem; 2004 Jun 04; 279(23):24803-12. PubMed ID: 15044456
    [Abstract] [Full Text] [Related]

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