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Journal Abstract Search

132 related items for PubMed ID: 9657198

  • 1. Inhibition of Ras and related G-proteins as a therapeutic strategy for blocking malignant glioma growth.
    Bredel M, Pollack IF, Freund JM, Hamilton AD, Sebti SM.
    Neurosurgery; 1998 Jul; 43(1):124-31; discussion 131-2. PubMed ID: 9657198
    [Abstract] [Full Text] [Related]

  • 2. Inhibition of Ras and related guanosine triphosphate-dependent proteins as a therapeutic strategy for blocking malignant glioma growth: II--preclinical studies in a nude mouse model.
    Pollack IF, Bredel M, Erff M, Hamilton AD, Sebti SM.
    Neurosurgery; 1999 Nov; 45(5):1208-14; discussion 1214-5. PubMed ID: 10549939
    [Abstract] [Full Text] [Related]

  • 3. Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.
    Lerner EC, Zhang TT, Knowles DB, Qian Y, Hamilton AD, Sebti SM.
    Oncogene; 1997 Sep; 15(11):1283-8. PubMed ID: 9315095
    [Abstract] [Full Text] [Related]

  • 4. Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
    Lobell RB, Omer CA, Abrams MT, Bhimnathwala HG, Brucker MJ, Buser CA, Davide JP, deSolms SJ, Dinsmore CJ, Ellis-Hutchings MS, Kral AM, Liu D, Lumma WC, Machotka SV, Rands E, Williams TM, Graham SL, Hartman GD, Oliff AI, Heimbrook DC, Kohl NE.
    Cancer Res; 2001 Dec 15; 61(24):8758-68. PubMed ID: 11751396
    [Abstract] [Full Text] [Related]

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  • 6. Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells.
    Morgan MA, Sebil T, Aydilek E, Peest D, Ganser A, Reuter CW.
    Br J Haematol; 2005 Sep 15; 130(6):912-25. PubMed ID: 16156861
    [Abstract] [Full Text] [Related]

  • 7. Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor.
    Kusama T, Mukai M, Tatsuta M, Matsumoto Y, Nakamura H, Inoue M.
    Clin Exp Metastasis; 2003 Sep 15; 20(6):561-7. PubMed ID: 14598891
    [Abstract] [Full Text] [Related]

  • 8. Farnesyl and geranylgeranyl transferase inhibitors induce G1 arrest by targeting the proteasome.
    Efuet ET, Keyomarsi K.
    Cancer Res; 2006 Jan 15; 66(2):1040-51. PubMed ID: 16424040
    [Abstract] [Full Text] [Related]

  • 9. Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells.
    Stark WW, Blaskovich MA, Johnson BA, Qian Y, Vasudevan A, Pitt B, Hamilton AD, Sebti SM, Davies P.
    Am J Physiol; 1998 Jul 15; 275(1):L55-63. PubMed ID: 9688935
    [Abstract] [Full Text] [Related]

  • 10. Farnesyltransferase inhibitor (L-744,832) restores TGF-beta type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2.
    Alcock RA, Dey S, Chendil D, Inayat MS, Mohiuddin M, Hartman G, Chatfield LK, Gallicchio VS, Ahmed MM.
    Oncogene; 2002 Nov 07; 21(51):7883-90. PubMed ID: 12420225
    [Abstract] [Full Text] [Related]

  • 11. The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells.
    Bolick SC, Landowski TH, Boulware D, Oshiro MM, Ohkanda J, Hamilton AD, Sebti SM, Dalton WS.
    Leukemia; 2003 Feb 07; 17(2):451-7. PubMed ID: 12592346
    [Abstract] [Full Text] [Related]

  • 12. Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.
    Vogt A, Qian Y, McGuire TF, Hamilton AD, Sebti SM.
    Oncogene; 1996 Nov 07; 13(9):1991-9. PubMed ID: 8934546
    [Abstract] [Full Text] [Related]

  • 13. Simvastatin-dependent apoptosis in Hodgkin's lymphoma cells and growth impairment of human Hodgkin's tumors in vivo.
    von Tresckow B, von Strandmann EP, Sasse S, Tawadros S, Engert A, Hansen HP.
    Haematologica; 2007 May 07; 92(5):682-5. PubMed ID: 17488694
    [Abstract] [Full Text] [Related]

  • 14. Synergistic cytotoxic effects in myeloid leukemia cells upon cotreatment with farnesyltransferase and geranylgeranyl transferase-I inhibitors.
    Morgan MA, Wegner J, Aydilek E, Ganser A, Reuter CW.
    Leukemia; 2003 Aug 07; 17(8):1508-20. PubMed ID: 12886237
    [Abstract] [Full Text] [Related]

  • 15. Direct stimulation of apoptotic signaling by soluble Apo2l/tumor necrosis factor-related apoptosis-inducing ligand leads to selective killing of glioma cells.
    Pollack IF, Erff M, Ashkenazi A.
    Clin Cancer Res; 2001 May 07; 7(5):1362-9. PubMed ID: 11350907
    [Abstract] [Full Text] [Related]

  • 16. Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor.
    Lerner EC, Qian Y, Hamilton AD, Sebti SM.
    J Biol Chem; 1995 Nov 10; 270(45):26770-3. PubMed ID: 7592913
    [Abstract] [Full Text] [Related]

  • 17. Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activation and G(1)-S transition in Ki-Ras-overexpressing transformed adrenocortical cells.
    Mazet JL, Padieu M, Osman H, Maume G, Mailliet P, Dereu N, Hamilton AD, Lavelle F, Sebti SM, Maume BF.
    FEBS Lett; 1999 Oct 29; 460(2):235-40. PubMed ID: 10544242
    [Abstract] [Full Text] [Related]

  • 18. Inhibition of geranylgeranylation mediates sensitivity to CHOP-induced cell death of DLBCL cell lines.
    Ageberg M, Rydström K, Lindén O, Linderoth J, Jerkeman M, Drott K.
    Exp Cell Res; 2011 May 01; 317(8):1179-91. PubMed ID: 21324313
    [Abstract] [Full Text] [Related]

  • 19. GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells.
    Miquel K, Pradines A, Sun J, Qian Y, Hamilton AD, Sebti SM, Favre G.
    Cancer Res; 1997 May 15; 57(10):1846-50. PubMed ID: 9157972
    [Abstract] [Full Text] [Related]

  • 20. Pamidronate, farnesyl transferase, and geranylgeranyl transferase-I inhibitors affects cell proliferation, apoptosis, and OPG/RANKL mRNA expression in stromal cells of giant cell tumor of bone.
    Lau CP, Huang L, Tsui SK, Ng PK, Leung PY, Kumta SM.
    J Orthop Res; 2011 Mar 15; 29(3):403-13. PubMed ID: 20886653
    [Abstract] [Full Text] [Related]

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