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460 related items for PubMed ID: 9657734

  • 1. Mutations in the E-domain of RAR portion of the PML/RAR chimeric gene may confer clinical resistance to all-trans retinoic acid in acute promyelocytic leukemia.
    Imaizumi M, Suzuki H, Yoshinari M, Sato A, Saito T, Sugawara A, Tsuchiya S, Hatae Y, Fujimoto T, Kakizuka A, Konno T, Iinuma K.
    Blood; 1998 Jul 15; 92(2):374-82. PubMed ID: 9657734
    [Abstract] [Full Text] [Related]

  • 2. Missense mutations in the PML/RARalpha ligand binding domain in ATRA-resistant As(2)O(3) sensitive relapsed acute promyelocytic leukemia.
    Marasca R, Zucchini P, Galimberti S, Leonardi G, Vaccari P, Donelli A, Luppi M, Petrini M, Torelli G.
    Haematologica; 1999 Nov 15; 84(11):963-8. PubMed ID: 10553155
    [Abstract] [Full Text] [Related]

  • 3. Novel mutation in the PML/RARalpha chimeric gene exhibits dramatically decreased ligand-binding activity and confers acquired resistance to retinoic acid in acute promyelocytic leukemia.
    Takayama N, Kizaki M, Hida T, Kinjo K, Ikeda Y.
    Exp Hematol; 2001 Jul 15; 29(7):864-72. PubMed ID: 11438209
    [Abstract] [Full Text] [Related]

  • 4. Leukemic cellular retinoic acid resistance and missense mutations in the PML-RARalpha fusion gene after relapse of acute promyelocytic leukemia from treatment with all-trans retinoic acid and intensive chemotherapy.
    Ding W, Li YP, Nobile LM, Grills G, Carrera I, Paietta E, Tallman MS, Wiernik PH, Gallagher RE.
    Blood; 1998 Aug 15; 92(4):1172-83. PubMed ID: 9694705
    [Abstract] [Full Text] [Related]

  • 5. Targeting of PML/RARalpha is lethal to retinoic acid-resistant promyelocytic leukemia cells.
    Nason-Burchenal K, Allopenna J, Bègue A, Stéhelin D, Dmitrovsky E, Martin P.
    Blood; 1998 Sep 01; 92(5):1758-67. PubMed ID: 9716606
    [Abstract] [Full Text] [Related]

  • 6. Response to histone deacetylase inhibition of novel PML/RARalpha mutants detected in retinoic acid-resistant APL cells.
    Côté S, Rosenauer A, Bianchini A, Seiter K, Vandewiele J, Nervi C, Miller WH.
    Blood; 2002 Oct 01; 100(7):2586-96. PubMed ID: 12239173
    [Abstract] [Full Text] [Related]

  • 7. Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia.
    Guidez F, Ivins S, Zhu J, Söderström M, Waxman S, Zelent A.
    Blood; 1998 Apr 15; 91(8):2634-42. PubMed ID: 9531570
    [Abstract] [Full Text] [Related]

  • 8. Altered nuclear cofactor switching in retinoic-resistant variants of the PML-RARα oncoprotein of acute promyelocytic leukemia.
    Farris M, Lague A, Manuelyan Z, Statnekov J, Francklyn C.
    Proteins; 2012 Apr 15; 80(4):1095-109. PubMed ID: 22228505
    [Abstract] [Full Text] [Related]

  • 9. Relapse of acute promyelocytic leukemia with PML-RARalpha mutant subclones independent of proximate all-trans retinoic acid selection pressure.
    Gallagher RE, Schachter-Tokarz EL, Zhou DC, Ding W, Kim SH, Sankoorikal BJ, Bi W, Livak KJ, Slack JL, Willman CL.
    Leukemia; 2006 Apr 15; 20(4):556-62. PubMed ID: 16437139
    [Abstract] [Full Text] [Related]

  • 10. Transcription therapy for acute promyelocytic leukaemia.
    Douer D.
    Expert Opin Investig Drugs; 2000 Feb 15; 9(2):329-46. PubMed ID: 11060680
    [Abstract] [Full Text] [Related]

  • 11. Variant-type PML-RAR(alpha) fusion transcript in acute promyelocytic leukemia: use of a cryptic coding sequence from intron 2 of the RAR(alpha) gene and identification of a new clinical subtype resistant to retinoic acid therapy.
    Gu BW, Xiong H, Zhou Y, Chen B, Wang L, Dong S, Yu ZY, Lu LF, Zhong M, Yin HF, Zhu GF, Huang W, Ren SX, Gallagher RE, Waxman S, Chen GQ, Wang ZG, Chen Z, Fu G, Chen SJ.
    Proc Natl Acad Sci U S A; 2002 May 28; 99(11):7640-5. PubMed ID: 12032336
    [Abstract] [Full Text] [Related]

  • 12. Altered ligand binding and transcriptional regulation by mutations in the PML/RARalpha ligand-binding domain arising in retinoic acid-resistant patients with acute promyelocytic leukemia.
    Côté S, Zhou D, Bianchini A, Nervi C, Gallagher RE, Miller WH.
    Blood; 2000 Nov 01; 96(9):3200-8. PubMed ID: 11050004
    [Abstract] [Full Text] [Related]

  • 13. A retinoid-resistant acute promyelocytic leukemia subclone expresses a dominant negative PML-RAR alpha mutation.
    Shao W, Benedetti L, Lamph WW, Nervi C, Miller WH.
    Blood; 1997 Jun 15; 89(12):4282-9. PubMed ID: 9192750
    [Abstract] [Full Text] [Related]

  • 14. Acute promyelocytic leukemia: a novel PML/RARalpha fusion that generates a frameshift in the RARalpha transcript and ATRA resistance.
    Zayed A, Couban S, Hayne O, Sparavalo N, Shawwa A, Sadek I, Greer W.
    Leuk Lymphoma; 2007 Mar 15; 48(3):489-96. PubMed ID: 17454588
    [Abstract] [Full Text] [Related]

  • 15. Common defects of different retinoic acid resistant promyelocytic leukemia cells are persistent telomerase activity and nuclear body disorganization.
    Nason-Burchenal K, Maerz W, Albanell J, Allopenna J, Martin P, Moore MA, Dmitrovsky E.
    Differentiation; 1997 Aug 15; 61(5):321-31. PubMed ID: 9342843
    [Abstract] [Full Text] [Related]

  • 16. Alteration in the cellular response to retinoic acid of a human acute promyelocytic leukemia cell line, UF-1, carrying a patient-derived mutant PML-RARalpha chimeric gene.
    Sato A, Imaizumi M, Hoshi Y, Rikiishi T, Fujii K, Kizaki M, Kagechika H, Kakizuka A, Hayashi Y, Iinuma K.
    Leuk Res; 2004 Sep 15; 28(9):959-67. PubMed ID: 15234573
    [Abstract] [Full Text] [Related]

  • 17. TBLR1 fuses to retinoid acid receptor α in a variant t(3;17)(q26;q21) translocation of acute promyelocytic leukemia.
    Chen Y, Li S, Zhou C, Li C, Ru K, Rao Q, Xing H, Tian Z, Tang K, Mi Y, Wang B, Wang M, Wang J.
    Blood; 2014 Aug 07; 124(6):936-45. PubMed ID: 24782508
    [Abstract] [Full Text] [Related]

  • 18. Mutant AF-2 domain of PML-RARalpha in retinoic acid-resistant NB4 cells: differentiation induced by RA is triggered directly through PML-RARalpha and its down-regulation in acute promyelocytic leukemia.
    Kitamura K, Kiyoi H, Yoshida H, Saito H, Ohno R, Naoe T.
    Leukemia; 1997 Nov 07; 11(11):1950-6. PubMed ID: 9369431
    [Abstract] [Full Text] [Related]

  • 19. Frequent mutations in the ligand-binding domain of PML-RARalpha after multiple relapses of acute promyelocytic leukemia: analysis for functional relationship to response to all-trans retinoic acid and histone deacetylase inhibitors in vitro and in vivo.
    Zhou DC, Kim SH, Ding W, Schultz C, Warrell RP, Gallagher RE.
    Blood; 2002 Feb 15; 99(4):1356-63. PubMed ID: 11830487
    [Abstract] [Full Text] [Related]

  • 20. The molecular biology of acute promyelocytic leukemia.
    Slack JL, Gallagher RE.
    Cancer Treat Res; 1999 Feb 15; 99():75-124. PubMed ID: 9891864
    [Abstract] [Full Text] [Related]


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