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206 related items for PubMed ID: 9688935

  • 1. Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells.
    Stark WW, Blaskovich MA, Johnson BA, Qian Y, Vasudevan A, Pitt B, Hamilton AD, Sebti SM, Davies P.
    Am J Physiol; 1998 Jul; 275(1):L55-63. PubMed ID: 9688935
    [Abstract] [Full Text] [Related]

  • 2. Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.
    Lerner EC, Zhang TT, Knowles DB, Qian Y, Hamilton AD, Sebti SM.
    Oncogene; 1997 Sep; 15(11):1283-8. PubMed ID: 9315095
    [Abstract] [Full Text] [Related]

  • 3. Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth muscle cells.
    Finder JD, Litz JL, Blaskovich MA, McGuire TF, Qian Y, Hamilton AD, Davies P, Sebti SM.
    J Biol Chem; 1997 May 23; 272(21):13484-8. PubMed ID: 9153192
    [Abstract] [Full Text] [Related]

  • 4. Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.
    Vogt A, Qian Y, McGuire TF, Hamilton AD, Sebti SM.
    Oncogene; 1996 Nov 07; 13(9):1991-9. PubMed ID: 8934546
    [Abstract] [Full Text] [Related]

  • 5. Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts.
    Sun J, Qian Y, Hamilton AD, Sebti SM.
    Oncogene; 1998 Mar 07; 16(11):1467-73. PubMed ID: 9525745
    [Abstract] [Full Text] [Related]

  • 6. Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation.
    McGuire TF, Qian Y, Vogt A, Hamilton AD, Sebti SM.
    J Biol Chem; 1996 Nov 01; 271(44):27402-7. PubMed ID: 8910319
    [Abstract] [Full Text] [Related]

  • 7. Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells.
    Li X, Liu L, Tupper JC, Bannerman DD, Winn RK, Sebti SM, Hamilton AD, Harlan JM.
    J Biol Chem; 2002 May 03; 277(18):15309-16. PubMed ID: 11839765
    [Abstract] [Full Text] [Related]

  • 8. Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activation and G(1)-S transition in Ki-Ras-overexpressing transformed adrenocortical cells.
    Mazet JL, Padieu M, Osman H, Maume G, Mailliet P, Dereu N, Hamilton AD, Lavelle F, Sebti SM, Maume BF.
    FEBS Lett; 1999 Oct 29; 460(2):235-40. PubMed ID: 10544242
    [Abstract] [Full Text] [Related]

  • 9. Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
    Lobell RB, Omer CA, Abrams MT, Bhimnathwala HG, Brucker MJ, Buser CA, Davide JP, deSolms SJ, Dinsmore CJ, Ellis-Hutchings MS, Kral AM, Liu D, Lumma WC, Machotka SV, Rands E, Williams TM, Graham SL, Hartman GD, Oliff AI, Heimbrook DC, Kohl NE.
    Cancer Res; 2001 Dec 15; 61(24):8758-68. PubMed ID: 11751396
    [Abstract] [Full Text] [Related]

  • 10. Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells.
    Morgan MA, Sebil T, Aydilek E, Peest D, Ganser A, Reuter CW.
    Br J Haematol; 2005 Sep 15; 130(6):912-25. PubMed ID: 16156861
    [Abstract] [Full Text] [Related]

  • 11. The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner.
    Vogt A, Sun J, Qian Y, Hamilton AD, Sebti SM.
    J Biol Chem; 1997 Oct 24; 272(43):27224-9. PubMed ID: 9341167
    [Abstract] [Full Text] [Related]

  • 12. GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells.
    Miquel K, Pradines A, Sun J, Qian Y, Hamilton AD, Sebti SM, Favre G.
    Cancer Res; 1997 May 15; 57(10):1846-50. PubMed ID: 9157972
    [Abstract] [Full Text] [Related]

  • 13. Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor.
    Kusama T, Mukai M, Tatsuta M, Matsumoto Y, Nakamura H, Inoue M.
    Clin Exp Metastasis; 2003 May 15; 20(6):561-7. PubMed ID: 14598891
    [Abstract] [Full Text] [Related]

  • 14. Protein isoprenylation regulates secretion of matrix metalloproteinase 1 from rheumatoid synovial fibroblasts: effects of statins and farnesyl and geranylgeranyl transferase inhibitors.
    Abeles AM, Marjanovic N, Park J, Attur M, Chan ES, Al-Mussawir HE, Dave M, Fisher MC, Stuchin SA, Abramson SB, Pillinger MH.
    Arthritis Rheum; 2007 Sep 15; 56(9):2840-53. PubMed ID: 17763406
    [Abstract] [Full Text] [Related]

  • 15. The role of geranylgeranylated proteins in human mesangial cell proliferation.
    Khwaja A, Sharpe CC, Noor M, Hendry BM.
    Kidney Int; 2006 Oct 15; 70(7):1296-304. PubMed ID: 16929252
    [Abstract] [Full Text] [Related]

  • 16. Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.
    Sun J, Blaskovich MA, Knowles D, Qian Y, Ohkanda J, Bailey RD, Hamilton AD, Sebti SM.
    Cancer Res; 1999 Oct 01; 59(19):4919-26. PubMed ID: 10519405
    [Abstract] [Full Text] [Related]

  • 17. Potent suppression of proliferation of a10 vascular smooth muscle cells by combined treatment with lovastatin and 3-allylfarnesol, an inhibitor of protein farnesyltransferase.
    Mattingly RR, Gibbs RA, Menard RE, Reiners JJ.
    J Pharmacol Exp Ther; 2002 Oct 01; 303(1):74-81. PubMed ID: 12235235
    [Abstract] [Full Text] [Related]

  • 18. Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells.
    Xia Z, Tan MM, Wong WW, Dimitroulakos J, Minden MD, Penn LZ.
    Leukemia; 2001 Sep 01; 15(9):1398-407. PubMed ID: 11516100
    [Abstract] [Full Text] [Related]

  • 19. Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice.
    Sun J, Ohkanda J, Coppola D, Yin H, Kothare M, Busciglio B, Hamilton AD, Sebti SM.
    Cancer Res; 2003 Dec 15; 63(24):8922-9. PubMed ID: 14695209
    [Abstract] [Full Text] [Related]

  • 20. MEK and ERK activation in ras-disabled RBL-2H3 mast cells and novel roles for geranylgeranylated and farnesylated proteins in Fc epsilonRI-mediated signaling.
    Graham TE, Pfeiffer JR, Lee RJ, Kusewitt DF, Martinez AM, Foutz T, Wilson BS, Oliver JM.
    J Immunol; 1998 Dec 15; 161(12):6733-44. PubMed ID: 9862703
    [Abstract] [Full Text] [Related]

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