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112 related items for PubMed ID: 9719453

  • 1. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in human hepatic microsomes by ipomeanol analogs--an exploratory study.
    Nunes MG, Desai D, Koehl W, Spratt TE, Guengerich FP, Amin S.
    Cancer Lett; 1998 Jul 17; 129(2):131-8. PubMed ID: 9719453
    [Abstract] [Full Text] [Related]

  • 2. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone pulmonary metabolism and tumorigenicity in mice by analogues of the investigational chemotherapeutic drug 4-ipomeanol.
    Lin JM, Desai DH, Morse MA, Amin S, Hecht SS.
    Chem Res Toxicol; 1992 Jul 17; 5(5):674-9. PubMed ID: 1446008
    [Abstract] [Full Text] [Related]

  • 3. Synthesis and bioassay of 4-ipomeanol analogs as potential chemopreventive agents against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced tumorigenicity in A/J mice.
    Desai D, Chang L, Amin S.
    Cancer Lett; 1996 Nov 29; 108(2):263-70. PubMed ID: 8973604
    [Abstract] [Full Text] [Related]

  • 4. Ipomeanol analogs as chemopreventive agents: effect on the in vitro metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
    Desai D, Nunes M, Chang L, Lin JM, Jiao D, Amin S.
    Cancer Lett; 1995 Nov 06; 97(2):155-62. PubMed ID: 7497457
    [Abstract] [Full Text] [Related]

  • 5. Enzymes involved in the bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in patas monkey lung and liver microsomes.
    Smith TJ, Liao AM, Liu Y, Jones AB, Anderson LM, Yang CS.
    Carcinogenesis; 1997 Aug 06; 18(8):1577-84. PubMed ID: 9276633
    [Abstract] [Full Text] [Related]

  • 6. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells.
    Smith TJ, Guo Z, Gonzalez FJ, Guengerich FP, Stoner GD, Yang CS.
    Cancer Res; 1992 Apr 01; 52(7):1757-63. PubMed ID: 1312898
    [Abstract] [Full Text] [Related]

  • 7. Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in lung tissue from mouse, rat, hamster, and man.
    Richter E, Engl J, Friesenegger S, Tricker AR.
    Chem Res Toxicol; 2009 Jun 01; 22(6):1008-17. PubMed ID: 19408892
    [Abstract] [Full Text] [Related]

  • 8. Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and N'- nitrosonornicotine in human hepatic microsomes.
    Staretz ME, Murphy SE, Patten CJ, Nunes MG, Koehl W, Amin S, Koenig LA, Guengerich FP, Hecht SS.
    Drug Metab Dispos; 1997 Feb 01; 25(2):154-62. PubMed ID: 9029045
    [Abstract] [Full Text] [Related]

  • 9. Effect of tobacco smoke condensate on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by adult and fetal hamster microsomes.
    Jorquera R, Castonguay A, Schuller HM.
    Drug Metab Dispos; 1993 Feb 01; 21(2):318-24. PubMed ID: 8097703
    [Abstract] [Full Text] [Related]

  • 10. Mechanisms of inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation in mouse by dietary phenethyl isothiocyanate.
    Smith TJ, Guo Z, Li C, Ning SM, Thomas PE, Yang CS.
    Cancer Res; 1993 Jul 15; 53(14):3276-82. PubMed ID: 8324738
    [Abstract] [Full Text] [Related]

  • 11. Activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung microsomes by cytochromes P450, lipoxygenase, and hydroperoxides.
    Smith TJ, Stoner GD, Yang CS.
    Cancer Res; 1995 Dec 01; 55(23):5566-73. PubMed ID: 7585636
    [Abstract] [Full Text] [Related]

  • 12. Kinetic analysis of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes and the effect of P450-specific chemical inhibitors on this activation in human liver microsomes.
    Patten CJ, Smith TJ, Murphy SE, Wang MH, Lee J, Tynes RE, Koch P, Yang CS.
    Arch Biochem Biophys; 1996 Sep 01; 333(1):127-38. PubMed ID: 8806763
    [Abstract] [Full Text] [Related]

  • 13. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by inducible and constitutive cytochrome P450 enzymes in rats.
    Guo Z, Smith TJ, Thomas PE, Yang CS.
    Arch Biochem Biophys; 1992 Oct 01; 298(1):279-86. PubMed ID: 1524438
    [Abstract] [Full Text] [Related]

  • 14. Absence of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by flavin-containing monooxygenase (FMO).
    Lamoureux J, Castonguay A.
    Carcinogenesis; 1997 Oct 01; 18(10):1979-84. PubMed ID: 9364009
    [Abstract] [Full Text] [Related]

  • 15. Effects of pregnancy and ethanol treatment on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by hamster liver and lung microsomes.
    Jorquera R, Castonguay A, Schuller HM.
    Drug Metab Dispos; 1992 Oct 01; 20(4):510-7. PubMed ID: 1356727
    [Abstract] [Full Text] [Related]

  • 16. Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.
    Zhou X, D'Agostino J, Xie F, Ding X.
    J Pharmacol Exp Ther; 2012 Apr 01; 341(1):233-41. PubMed ID: 22262919
    [Abstract] [Full Text] [Related]

  • 17. Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13.
    Jalas JR, Ding X, Murphy SE.
    Drug Metab Dispos; 2003 Oct 01; 31(10):1199-202. PubMed ID: 12975327
    [Abstract] [Full Text] [Related]

  • 18. Quantitation of microsomal alpha-hydroxylation of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
    Peterson LA, Mathew R, Hecht SS.
    Cancer Res; 1991 Oct 15; 51(20):5495-500. PubMed ID: 1913670
    [Abstract] [Full Text] [Related]

  • 19. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes and its inhibition by isothiocyanates.
    Smith TJ, Guo ZY, Thomas PE, Chung FL, Morse MA, Elkind K, Yang CS.
    Cancer Res; 1990 Nov 01; 50(21):6817-22. PubMed ID: 2208146
    [Abstract] [Full Text] [Related]

  • 20. 11Beta-hydroxysteroid dehydrogenase responsible for carbonyl reduction of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes.
    Maser E.
    Cancer Res; 1998 Jul 15; 58(14):2996-3003. PubMed ID: 9679962
    [Abstract] [Full Text] [Related]

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