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263 related items for PubMed ID: 9720765

  • 1. Comparison of recombinant human PDE4 isoforms: interaction with substrate and inhibitors.
    Saldou N, Obernolte R, Huber A, Baecker PA, Wilhelm R, Alvarez R, Li B, Xia L, Callan O, Su C, Jarnagin K, Shelton ER.
    Cell Signal; 1998 Jun; 10(6):427-40. PubMed ID: 9720765
    [Abstract] [Full Text] [Related]

  • 2. Identification of inhibitor binding sites of the cAMP-specific phosphodiesterase 4.
    Richter W, Unciuleac L, Hermsdorf T, Kronbach T, Dettmer D.
    Cell Signal; 2001 Apr; 13(4):287-97. PubMed ID: 11306246
    [Abstract] [Full Text] [Related]

  • 3. Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process.
    Terry R, Cheung YF, Praestegaard M, Baillie GS, Huston E, Gall I, Adams DR, Houslay MD.
    Cell Signal; 2003 Oct; 15(10):955-71. PubMed ID: 12873709
    [Abstract] [Full Text] [Related]

  • 4. UCR1 and UCR2 domains unique to the cAMP-specific phosphodiesterase family form a discrete module via electrostatic interactions.
    Beard MB, Olsen AE, Jones RE, Erdogan S, Houslay MD, Bolger GB.
    J Biol Chem; 2000 Apr 07; 275(14):10349-58. PubMed ID: 10744723
    [Abstract] [Full Text] [Related]

  • 5. The oligomerization state determines regulatory properties and inhibitor sensitivity of type 4 cAMP-specific phosphodiesterases.
    Richter W, Conti M.
    J Biol Chem; 2004 Jul 16; 279(29):30338-48. PubMed ID: 15131123
    [Abstract] [Full Text] [Related]

  • 6. Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells.
    Owens RJ, Catterall C, Batty D, Jappy J, Russell A, Smith B, O'Connell J, Perry MJ.
    Biochem J; 1997 Aug 15; 326 ( Pt 1)(Pt 1):53-60. PubMed ID: 9337850
    [Abstract] [Full Text] [Related]

  • 7. Characterization of the rolipram-sensitive, cyclic AMP-specific phosphodiesterases: identification and differential expression of immunologically distinct forms in the rat brain.
    Iona S, Cuomo M, Bushnik T, Naro F, Sette C, Hess M, Shelton ER, Conti M.
    Mol Pharmacol; 1998 Jan 15; 53(1):23-32. PubMed ID: 9443929
    [Abstract] [Full Text] [Related]

  • 8. Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2.
    Bolger GB, Peden AH, Steele MR, MacKenzie C, McEwan DG, Wallace DA, Huston E, Baillie GS, Houslay MD.
    J Biol Chem; 2003 Aug 29; 278(35):33351-63. PubMed ID: 12810716
    [Abstract] [Full Text] [Related]

  • 9. Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue.
    Richter W, Jin SL, Conti M.
    Biochem J; 2005 Jun 15; 388(Pt 3):803-11. PubMed ID: 15717866
    [Abstract] [Full Text] [Related]

  • 10. Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene.
    Johnston LA, Erdogan S, Cheung YF, Sullivan M, Barber R, Lynch MJ, Baillie GS, Van Heeke G, Adams DR, Huston E, Houslay MD.
    Biochem J; 2004 Jun 01; 380(Pt 2):371-84. PubMed ID: 15025561
    [Abstract] [Full Text] [Related]

  • 11. Identification of substrate specificity determinants in human cAMP-specific phosphodiesterase 4A by single-point mutagenesis.
    Richter W, Unciuleac L, Hermsdorf T, Kronbach T, Dettmer D.
    Cell Signal; 2001 Mar 01; 13(3):159-67. PubMed ID: 11282454
    [Abstract] [Full Text] [Related]

  • 12. In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region.
    McCahill A, McSorley T, Huston E, Hill EV, Lynch MJ, Gall I, Keryer G, Lygren B, Tasken K, van Heeke G, Houslay MD.
    Cell Signal; 2005 Sep 01; 17(9):1158-73. PubMed ID: 15905070
    [Abstract] [Full Text] [Related]

  • 13. Dissecting the cofactor-dependent and independent bindings of PDE4 inhibitors.
    Liu S, Laliberté F, Bobechko B, Bartlett A, Lario P, Gorseth E, Van Hamme J, Gresser MJ, Huang Z.
    Biochemistry; 2001 Aug 28; 40(34):10179-86. PubMed ID: 11513595
    [Abstract] [Full Text] [Related]

  • 14. Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1).
    MacKenzie SJ, Baillie GS, McPhee I, MacKenzie C, Seamons R, McSorley T, Millen J, Beard MB, van Heeke G, Houslay MD.
    Br J Pharmacol; 2002 Jun 28; 136(3):421-33. PubMed ID: 12023945
    [Abstract] [Full Text] [Related]

  • 15. Characterization of phosphodiesterase 4 in guinea-pig macrophages: multiple activities, association states and sensitivity to selective inhibitors.
    Kelly JJ, Barnes PJ, Giembycz MA.
    Br J Pharmacol; 1998 May 28; 124(1):129-40. PubMed ID: 9630352
    [Abstract] [Full Text] [Related]

  • 16. Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia.
    Moon E, Lee R, Near R, Weintraub L, Wolda S, Lerner A.
    Clin Cancer Res; 2002 Feb 28; 8(2):589-95. PubMed ID: 11839681
    [Abstract] [Full Text] [Related]

  • 17. Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B.
    Manning CD, Burman M, Christensen SB, Cieslinski LB, Essayan DM, Grous M, Torphy TJ, Barnette MS.
    Br J Pharmacol; 1999 Dec 28; 128(7):1393-8. PubMed ID: 10602317
    [Abstract] [Full Text] [Related]

  • 18. Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.
    Huston E, Lumb S, Russell A, Catterall C, Ross AH, Steele MR, Bolger GB, Perry MJ, Owens RJ, Houslay MD.
    Biochem J; 1997 Dec 01; 328 ( Pt 2)(Pt 2):549-58. PubMed ID: 9371714
    [Abstract] [Full Text] [Related]

  • 19. Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme.
    Zhang HT, Huang Y, Jin SL, Frith SA, Suvarna N, Conti M, O'Donnell JM.
    Neuropsychopharmacology; 2002 Oct 01; 27(4):587-95. PubMed ID: 12377395
    [Abstract] [Full Text] [Related]

  • 20. Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene.
    Bolger GB, Erdogan S, Jones RE, Loughney K, Scotland G, Hoffmann R, Wilkinson I, Farrell C, Houslay MD.
    Biochem J; 1997 Dec 01; 328 ( Pt 2)(Pt 2):539-48. PubMed ID: 9371713
    [Abstract] [Full Text] [Related]

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