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Journal Abstract Search

291 related items for PubMed ID: 9733491

  • 1. Rational design, synthesis, and X-ray structure of selective noncovalent thrombin inhibitors.
    Wagner J, Kallen J, Ehrhardt C, Evenou JP, Wagner D.
    J Med Chem; 1998 Sep 10; 41(19):3664-74. PubMed ID: 9733491
    [Abstract] [Full Text] [Related]

  • 2. Potent thrombin inhibitors that probe the S1 subsite: tripeptide transition state analogues based on a heterocycle-activated carbonyl group.
    Costanzo MJ, Maryanoff BE, Hecker LR, Schott MR, Yabut SC, Zhang HC, Andrade-Gordon P, Kauffman JA, Lewis JM, Krishnan R, Tulinsky A.
    J Med Chem; 1996 Aug 02; 39(16):3039-43. PubMed ID: 8759623
    [No Abstract] [Full Text] [Related]

  • 3. Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes.
    Krishnan R, Zhang E, Hakansson K, Arni RK, Tulinsky A, Lim-Wilby MS, Levy OE, Semple JE, Brunck TK.
    Biochemistry; 1998 Sep 01; 37(35):12094-103. PubMed ID: 9724521
    [Abstract] [Full Text] [Related]

  • 4. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
    Costanzo MJ, Almond HR, Hecker LR, Schott MR, Yabut SC, Zhang HC, Andrade-Gordon P, Corcoran TW, Giardino EC, Kauffman JA, Lewis JM, de Garavilla L, Haertlein BJ, Maryanoff BE.
    J Med Chem; 2005 Mar 24; 48(6):1984-2008. PubMed ID: 15771442
    [Abstract] [Full Text] [Related]

  • 5. Highly efficient and versatile synthesis of libraries of constrained beta-strand mimetics.
    Ogbu CO, Qabar MN, Boatman PD, Urban J, Meara JP, Ferguson MD, Tulinsky J, Lum C, Babu S, Blaskovich MA, Nakanishi H, Ruan F, Cao B, Minarik R, Little T, Nelson S, Nguyen M, Gall A, Kahn M.
    Bioorg Med Chem Lett; 1998 Sep 08; 8(17):2321-6. PubMed ID: 9873535
    [Abstract] [Full Text] [Related]

  • 6. Profiling the structural determinants for the selectivity of representative factor-Xa and thrombin inhibitors using combined ligand-based and structure-based approaches.
    Bhunia SS, Roy KK, Saxena AK.
    J Chem Inf Model; 2011 Aug 22; 51(8):1966-85. PubMed ID: 21761917
    [Abstract] [Full Text] [Related]

  • 7. Molecular design and characterization of an alpha-thrombin inhibitor containing a novel P1 moiety.
    Malikayil JA, Burkhart JP, Schreuder HA, Broersma RJ, Tardif C, Kutcher LW, Mehdi S, Schatzman GL, Neises B, Peet NP.
    Biochemistry; 1997 Feb 04; 36(5):1034-40. PubMed ID: 9033393
    [Abstract] [Full Text] [Related]

  • 8. (Z,Z)-2,7-Bis(4-amidinobenzylidene)cycloheptan-1-one: identification of a highly active inhibitor of blood coagulation factor Xa.
    Shaw KJ, Guilford WJ, Dallas JL, Koovakkaat SK, McCarrick MA, Liang A, Light DR, Morrissey MM.
    J Med Chem; 1998 Sep 10; 41(19):3551-6. PubMed ID: 9733479
    [No Abstract] [Full Text] [Related]

  • 9. Design, synthesis and biological evaluation of selective boron-containing thrombin inhibitors.
    Wienand A, Ehrhardt C, Metternich R, Tapparelli C.
    Bioorg Med Chem; 1999 Jul 10; 7(7):1295-307. PubMed ID: 10465405
    [Abstract] [Full Text] [Related]

  • 10. Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: molecular and X-ray crystallographic studies.
    De Simone G, Menchise V, Omaggio S, Pedone C, Scozzafava A, Supuran CT.
    Biochemistry; 2003 Aug 05; 42(30):9013-21. PubMed ID: 12885234
    [Abstract] [Full Text] [Related]

  • 11. Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.
    Phillips GB, Buckman BO, Davey DD, Eagen KA, Guilford WJ, Hinchman J, Ho E, Koovakkat S, Liang A, Light DR, Mohan R, Ng HP, Post JM, Shaw KJ, Smith D, Subramanyam B, Sullivan ME, Trinh L, Vergona R, Walters J, White K, Whitlow M, Wu S, Xu W, Morrissey MM.
    J Med Chem; 1998 Sep 10; 41(19):3557-62. PubMed ID: 9733480
    [No Abstract] [Full Text] [Related]

  • 12. Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition.
    Dullweber F, Stubbs MT, Musil D, Stürzebecher J, Klebe G.
    J Mol Biol; 2001 Oct 26; 313(3):593-614. PubMed ID: 11676542
    [Abstract] [Full Text] [Related]

  • 13. Bound structures of novel P3-P1' beta-strand mimetic inhibitors of thrombin.
    St Charles R, Matthews JH, Zhang E, Tulinsky A.
    J Med Chem; 1999 Apr 22; 42(8):1376-83. PubMed ID: 10212123
    [Abstract] [Full Text] [Related]

  • 14. Compounds binding to the S2-S3 pockets of thrombin.
    Nilsson M, Hämäläinen M, Ivarsson M, Gottfries J, Xue Y, Hansson S, Isaksson R, Fex T.
    J Med Chem; 2009 May 14; 52(9):2708-15. PubMed ID: 19371038
    [Abstract] [Full Text] [Related]

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    [No Abstract] [Full Text] [Related]

  • 16. Urethanyl-3-amidinophenylalanine derivatives as inhibitors of factor Xa. X-ray crystal structure of a trypsin/inhibitor complex and modeling studies.
    Sperl S, Bergner A, Stürzebecher J, Magdolen V, Bode W, Moroder L.
    Biol Chem; 2000 Apr 14; 381(4):321-9. PubMed ID: 10839461
    [Abstract] [Full Text] [Related]

  • 17. Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease inhibitors.
    Katz BA, Elrod K, Verner E, Mackman RL, Luong C, Shrader WD, Sendzik M, Spencer JR, Sprengeler PA, Kolesnikov A, Tai VW, Hui HC, Breitenbucher JG, Allen D, Janc JW.
    J Mol Biol; 2003 May 23; 329(1):93-120. PubMed ID: 12742021
    [Abstract] [Full Text] [Related]

  • 18. Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin.
    Stubbs MT, Huber R, Bode W.
    FEBS Lett; 1995 Nov 13; 375(1-2):103-7. PubMed ID: 7498454
    [Abstract] [Full Text] [Related]

  • 19. Molecular recognition at the thrombin active site: structure-based design and synthesis of potent and selective thrombin inhibitors and the X-ray crystal structures of two thrombin-inhibitor complexes.
    Obst U, Banner DW, Weber L, Diederich F.
    Chem Biol; 1997 Apr 13; 4(4):287-95. PubMed ID: 9195869
    [Abstract] [Full Text] [Related]

  • 20. Comparison of the structures of the cyclotheonamide A complexes of human alpha-thrombin and bovine beta-trypsin.
    Ganesh V, Lee AY, Clardy J, Tulinsky A.
    Protein Sci; 1996 May 13; 5(5):825-35. PubMed ID: 8732754
    [Abstract] [Full Text] [Related]

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