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Journal Abstract Search

615 related items for PubMed ID: 9733665

  • 1. Human cytochrome P450-catalyzed conversion of the proestrogenic pesticide methoxychlor into an estrogen. Role of CYP2C19 and CYP1A2 in O-demethylation.
    Stresser DM, Kupfer D.
    Drug Metab Dispos; 1998 Sep; 26(9):868-74. PubMed ID: 9733665
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  • 2. Metabolism of the endocrine disruptor pesticide-methoxychlor by human P450s: pathways involving a novel catechol metabolite.
    Hu Y, Kupfer D.
    Drug Metab Dispos; 2002 Sep; 30(9):1035-42. PubMed ID: 12167570
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  • 3. Enantioselective metabolism of the endocrine disruptor pesticide methoxychlor by human cytochromes P450 (P450s): major differences in selective enantiomer formation by various P450 isoforms.
    Hu Y, Kupfer D.
    Drug Metab Dispos; 2002 Dec; 30(12):1329-36. PubMed ID: 12433799
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  • 4. CYP2C subfamily, primarily CYP2C9, catalyses the enantioselective demethylation of the endocrine disruptor pesticide methoxychlor in human liver microsomes: use of inhibitory monoclonal antibodies in P450 identification.
    Hu Y, Krausz K, Gelboin HV, Kupfer D.
    Xenobiotica; 2004 Feb; 34(2):117-32. PubMed ID: 14985143
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  • 5. Metabolism of the proestrogenic pesticide methoxychlor by hepatic P450 monooxygenases in rats and humans. Dual pathways involving novel ortho ring-hydroxylation by CYP2B.
    Dehal SS, Kupfer D.
    Drug Metab Dispos; 1994 Feb; 22(6):937-46. PubMed ID: 7895613
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  • 6. Prosubstrates of CYP3A4, the major human hepatic cytochrome P450: transformation into substrates by other P450 isoforms.
    Stresser DM, Kupfer D.
    Biochem Pharmacol; 1998 Jun 01; 55(11):1861-71. PubMed ID: 9714305
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  • 7. Cytochrome P450 2C9 catalyzes indomethacin O-demethylation in human liver microsomes.
    Nakajima M, Inoue T, Shimada N, Tokudome S, Yamamoto T, Kuroiwa Y.
    Drug Metab Dispos; 1998 Mar 01; 26(3):261-6. PubMed ID: 9492390
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  • 8. Interactions between CYP2C9 and CYP2C19 in reconstituted binary systems influence their catalytic activity: possible rationale for the inability of CYP2C19 to catalyze methoxychlor demethylation in human liver microsomes.
    Hazai E, Kupfer D.
    Drug Metab Dispos; 2005 Jan 01; 33(1):157-64. PubMed ID: 15486075
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  • 10. Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes.
    Karam WG, Goldstein JA, Lasker JM, Ghanayem BI.
    Drug Metab Dispos; 1996 Oct 01; 24(10):1081-7. PubMed ID: 8894508
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  • 11. Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.).
    Guo J, Nikolic D, Chadwick LR, Pauli GF, van Breemen RB.
    Drug Metab Dispos; 2006 Jul 01; 34(7):1152-9. PubMed ID: 16611861
    [Abstract] [Full Text] [Related]

  • 12. Reversible and time-dependent inhibition of the hepatic cytochrome P450 steroidal hydroxylases by the proestrogenic pesticide methoxychlor in rat and human.
    Li HC, Mani C, Kupfer D.
    J Biochem Toxicol; 1993 Dec 01; 8(4):195-206. PubMed ID: 8114062
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  • 13. In vitro metabolism of the calmodulin antagonist DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate) by human liver microsomes: involvement of cytochromes p450 in atypical kinetics and potential drug interactions.
    Tachibana S, Fujimaki Y, Yokoyama H, Okazaki O, Sudo K.
    Drug Metab Dispos; 2005 Nov 01; 33(11):1628-36. PubMed ID: 16049129
    [Abstract] [Full Text] [Related]

  • 14. Glucuronidation of the oxidative cytochrome P450-mediated phenolic metabolites of the endocrine disruptor pesticide: methoxychlor by human hepatic UDP-glucuronosyl transferases.
    Hazai E, Gagne PV, Kupfer D.
    Drug Metab Dispos; 2004 Jul 01; 32(7):742-51. PubMed ID: 15205390
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  • 17. Contribution of CYP2C9, CYP2A6, and CYP2B6 to valproic acid metabolism in hepatic microsomes from individuals with the CYP2C9*1/*1 genotype.
    Kiang TK, Ho PC, Anari MR, Tong V, Abbott FS, Chang TK.
    Toxicol Sci; 2006 Dec 01; 94(2):261-71. PubMed ID: 16945988
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  • 19. Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes.
    Komatsu T, Yamazaki H, Shimada N, Nakajima M, Yokoi T.
    Drug Metab Dispos; 2000 Dec 01; 28(12):1457-63. PubMed ID: 11095583
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  • 20. Mechanism of induction of cytochrome p450 enzymes by the proestrogenic endocrine disruptor pesticide-methoxychlor: interactions of methoxychlor metabolites with the constitutive androstane receptor system.
    Blizard D, Sueyoshi T, Negishi M, Dehal SS, Kupfer D.
    Drug Metab Dispos; 2001 Jun 01; 29(6):781-5. PubMed ID: 11353743
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