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615 related items for PubMed ID: 9733665

  • 1. Human cytochrome P450-catalyzed conversion of the proestrogenic pesticide methoxychlor into an estrogen. Role of CYP2C19 and CYP1A2 in O-demethylation.
    Stresser DM, Kupfer D.
    Drug Metab Dispos; 1998 Sep; 26(9):868-74. PubMed ID: 9733665
    [Abstract] [Full Text] [Related]

  • 2. Metabolism of the endocrine disruptor pesticide-methoxychlor by human P450s: pathways involving a novel catechol metabolite.
    Hu Y, Kupfer D.
    Drug Metab Dispos; 2002 Sep; 30(9):1035-42. PubMed ID: 12167570
    [Abstract] [Full Text] [Related]

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  • 4. CYP2C subfamily, primarily CYP2C9, catalyses the enantioselective demethylation of the endocrine disruptor pesticide methoxychlor in human liver microsomes: use of inhibitory monoclonal antibodies in P450 identification.
    Hu Y, Krausz K, Gelboin HV, Kupfer D.
    Xenobiotica; 2004 Feb; 34(2):117-32. PubMed ID: 14985143
    [Abstract] [Full Text] [Related]

  • 5. Metabolism of the proestrogenic pesticide methoxychlor by hepatic P450 monooxygenases in rats and humans. Dual pathways involving novel ortho ring-hydroxylation by CYP2B.
    Dehal SS, Kupfer D.
    Drug Metab Dispos; 1994 Feb; 22(6):937-46. PubMed ID: 7895613
    [Abstract] [Full Text] [Related]

  • 6. Prosubstrates of CYP3A4, the major human hepatic cytochrome P450: transformation into substrates by other P450 isoforms.
    Stresser DM, Kupfer D.
    Biochem Pharmacol; 1998 Jun 01; 55(11):1861-71. PubMed ID: 9714305
    [Abstract] [Full Text] [Related]

  • 7. Cytochrome P450 2C9 catalyzes indomethacin O-demethylation in human liver microsomes.
    Nakajima M, Inoue T, Shimada N, Tokudome S, Yamamoto T, Kuroiwa Y.
    Drug Metab Dispos; 1998 Mar 01; 26(3):261-6. PubMed ID: 9492390
    [Abstract] [Full Text] [Related]

  • 8. Interactions between CYP2C9 and CYP2C19 in reconstituted binary systems influence their catalytic activity: possible rationale for the inability of CYP2C19 to catalyze methoxychlor demethylation in human liver microsomes.
    Hazai E, Kupfer D.
    Drug Metab Dispos; 2005 Jan 01; 33(1):157-64. PubMed ID: 15486075
    [Abstract] [Full Text] [Related]

  • 9. O-Dealkylation of fluoxetine in relation to CYP2C19 gene dose and involvement of CYP3A4 in human liver microsomes.
    Liu ZQ, Zhu B, Tan YF, Tan ZR, Wang LS, Huang SL, Shu Y, Zhou HH.
    J Pharmacol Exp Ther; 2002 Jan 01; 300(1):105-11. PubMed ID: 11752104
    [Abstract] [Full Text] [Related]

  • 10. Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes.
    Karam WG, Goldstein JA, Lasker JM, Ghanayem BI.
    Drug Metab Dispos; 1996 Oct 01; 24(10):1081-7. PubMed ID: 8894508
    [Abstract] [Full Text] [Related]

  • 11. Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.).
    Guo J, Nikolic D, Chadwick LR, Pauli GF, van Breemen RB.
    Drug Metab Dispos; 2006 Jul 01; 34(7):1152-9. PubMed ID: 16611861
    [Abstract] [Full Text] [Related]

  • 12. Reversible and time-dependent inhibition of the hepatic cytochrome P450 steroidal hydroxylases by the proestrogenic pesticide methoxychlor in rat and human.
    Li HC, Mani C, Kupfer D.
    J Biochem Toxicol; 1993 Dec 01; 8(4):195-206. PubMed ID: 8114062
    [Abstract] [Full Text] [Related]

  • 13. In vitro metabolism of the calmodulin antagonist DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate) by human liver microsomes: involvement of cytochromes p450 in atypical kinetics and potential drug interactions.
    Tachibana S, Fujimaki Y, Yokoyama H, Okazaki O, Sudo K.
    Drug Metab Dispos; 2005 Nov 01; 33(11):1628-36. PubMed ID: 16049129
    [Abstract] [Full Text] [Related]

  • 14. Glucuronidation of the oxidative cytochrome P450-mediated phenolic metabolites of the endocrine disruptor pesticide: methoxychlor by human hepatic UDP-glucuronosyl transferases.
    Hazai E, Gagne PV, Kupfer D.
    Drug Metab Dispos; 2004 Jul 01; 32(7):742-51. PubMed ID: 15205390
    [Abstract] [Full Text] [Related]

  • 15. Identification of cytochrome P450 isoforms involved in citalopram N-demethylation by human liver microsomes.
    Kobayashi K, Chiba K, Yagi T, Shimada N, Taniguchi T, Horie T, Tani M, Yamamoto T, Ishizaki T, Kuroiwa Y.
    J Pharmacol Exp Ther; 1997 Feb 01; 280(2):927-33. PubMed ID: 9023308
    [Abstract] [Full Text] [Related]

  • 16. Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes.
    Yamazaki H, Shimada T.
    Arch Biochem Biophys; 1997 Oct 01; 346(1):161-9. PubMed ID: 9328296
    [Abstract] [Full Text] [Related]

  • 17. Contribution of CYP2C9, CYP2A6, and CYP2B6 to valproic acid metabolism in hepatic microsomes from individuals with the CYP2C9*1/*1 genotype.
    Kiang TK, Ho PC, Anari MR, Tong V, Abbott FS, Chang TK.
    Toxicol Sci; 2006 Dec 01; 94(2):261-71. PubMed ID: 16945988
    [Abstract] [Full Text] [Related]

  • 18. Further assessment of 17alpha-ethinyl estradiol as an inhibitor of different human cytochrome P450 forms in vitro.
    Chang SY, Chen C, Yang Z, Rodrigues AD.
    Drug Metab Dispos; 2009 Aug 01; 37(8):1667-75. PubMed ID: 19454483
    [Abstract] [Full Text] [Related]

  • 19. Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes.
    Komatsu T, Yamazaki H, Shimada N, Nakajima M, Yokoi T.
    Drug Metab Dispos; 2000 Dec 01; 28(12):1457-63. PubMed ID: 11095583
    [Abstract] [Full Text] [Related]

  • 20. Mechanism of induction of cytochrome p450 enzymes by the proestrogenic endocrine disruptor pesticide-methoxychlor: interactions of methoxychlor metabolites with the constitutive androstane receptor system.
    Blizard D, Sueyoshi T, Negishi M, Dehal SS, Kupfer D.
    Drug Metab Dispos; 2001 Jun 01; 29(6):781-5. PubMed ID: 11353743
    [Abstract] [Full Text] [Related]

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