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226 related items for PubMed ID: 9735103

  • 1. Kinetic analysis of an inhibitor-resistant variant of the OHIO-1 beta-lactamase, an SHV-family class A enzyme.
    Lin S, Thomas M, Shlaes DM, Rudin SD, Knox JR, Anderson V, Bonomo RA.
    Biochem J; 1998 Jul 15; 333 ( Pt 2)(Pt 2):395-400. PubMed ID: 9735103
    [Abstract] [Full Text] [Related]

  • 2. OHIO-1 beta-lactamase mutants: the Arg244Ser mutant and resistance to beta-lactams and beta-lactamase inhibitors.
    Lin S, Thomas M, Mark S, Anderson V, Bonomo RA.
    Biochim Biophys Acta; 1999 Jun 15; 1432(1):125-36. PubMed ID: 10366735
    [Abstract] [Full Text] [Related]

  • 3. Overcoming resistance to beta-lactamase inhibitors: comparing sulbactam to novel inhibitors against clavulanate resistant SHV enzymes with substitutions at Ambler position 244.
    Thomson JM, Distler AM, Bonomo RA.
    Biochemistry; 2007 Oct 09; 46(40):11361-8. PubMed ID: 17848099
    [Abstract] [Full Text] [Related]

  • 4. Aspartic acid for asparagine substitution at position 276 reduces susceptibility to mechanism-based inhibitors in SHV-1 and SHV-5 beta-lactamases.
    Giakkoupi P, Tzelepi E, Legakis NJ, Tzouvelekis LS.
    J Antimicrob Chemother; 1999 Jan 09; 43(1):23-9. PubMed ID: 10381097
    [Abstract] [Full Text] [Related]

  • 5. Construction and characterization of an OHIO-1 beta-lactamase bearing Met69Ile and Gly238Ser mutations.
    Bonomo RA, Knox JR, Rudin SD, Shlaes DM.
    Antimicrob Agents Chemother; 1997 Sep 09; 41(9):1940-3. PubMed ID: 9303389
    [Abstract] [Full Text] [Related]

  • 6. Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase.
    Papp-Wallace KM, Bethel CR, Distler AM, Kasuboski C, Taracila M, Bonomo RA.
    Antimicrob Agents Chemother; 2010 Feb 09; 54(2):890-7. PubMed ID: 20008772
    [Abstract] [Full Text] [Related]

  • 7. Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130.
    Helfand MS, Bethel CR, Hujer AM, Hujer KM, Anderson VE, Bonomo RA.
    J Biol Chem; 2003 Dec 26; 278(52):52724-9. PubMed ID: 14534312
    [Abstract] [Full Text] [Related]

  • 8. Tazobactam is a potent inactivator of selected inhibitor-resistant class A beta-lactamases.
    Bonomo RA, Rudin SA, Shlaes DM.
    FEMS Microbiol Lett; 1997 Mar 01; 148(1):59-62. PubMed ID: 9066111
    [Abstract] [Full Text] [Related]

  • 9. Evaluation of inhibition of the carbenicillin-hydrolyzing beta-lactamase PSE-4 by the clinically used mechanism-based inhibitors.
    Therrien C, Kotra LP, Sanschagrin F, Mobashery S, Levesque RC.
    FEBS Lett; 2000 Mar 31; 470(3):285-92. PubMed ID: 10745083
    [Abstract] [Full Text] [Related]

  • 10. Substitution of Met-69 by Ala or Gly in TEM-1 beta-lactamase confer an increased susceptibility to clavulanic acid and other inhibitors.
    Madec S, Blin C, Krishnamoorthy R, Picard B, Chaibi el B, Fouchereau-Péron M, Labia R.
    FEMS Microbiol Lett; 2002 May 21; 211(1):13-6. PubMed ID: 12052544
    [Abstract] [Full Text] [Related]

  • 11. Different intermediate populations formed by tazobactam, sulbactam, and clavulanate reacting with SHV-1 beta-lactamases: Raman crystallographic evidence.
    Kalp M, Totir MA, Buynak JD, Carey PR.
    J Am Chem Soc; 2009 Feb 18; 131(6):2338-47. PubMed ID: 19161282
    [Abstract] [Full Text] [Related]

  • 12. Complementary roles of mutations at positions 69 and 242 in a class A beta-lactamase.
    Bonomo RA, Dawes CG, Knox JR, Shlaes DM.
    Biochim Biophys Acta; 1995 Feb 22; 1247(1):113-20. PubMed ID: 7873579
    [Abstract] [Full Text] [Related]

  • 13. X-ray structure of the Asn276Asp variant of the Escherichia coli TEM-1 beta-lactamase: direct observation of electrostatic modulation in resistance to inactivation by clavulanic acid.
    Swarén P, Golemi D, Cabantous S, Bulychev A, Maveyraud L, Mobashery S, Samama JP.
    Biochemistry; 1999 Jul 27; 38(30):9570-6. PubMed ID: 10423234
    [Abstract] [Full Text] [Related]

  • 14. High resolution crystal structures of the trans-enamine intermediates formed by sulbactam and clavulanic acid and E166A SHV-1 {beta}-lactamase.
    Padayatti PS, Helfand MS, Totir MA, Carey MP, Carey PR, Bonomo RA, van den Akker F.
    J Biol Chem; 2005 Oct 14; 280(41):34900-7. PubMed ID: 16055923
    [Abstract] [Full Text] [Related]

  • 15. Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase.
    Papp-Wallace KM, Taracila M, Hornick JM, Hujer AM, Hujer KM, Distler AM, Endimiani A, Bonomo RA.
    Antimicrob Agents Chemother; 2010 Jul 14; 54(7):2867-77. PubMed ID: 20421396
    [Abstract] [Full Text] [Related]

  • 16. beta-Lactamase mutations far from the active site influence inhibitor binding.
    Bonomo RA, Dawes CG, Knox JR, Shlaes DM.
    Biochim Biophys Acta; 1995 Feb 22; 1247(1):121-5. PubMed ID: 7873581
    [Abstract] [Full Text] [Related]

  • 17. Characterization of a new TEM-type beta-lactamase resistant to clavulanate, sulbactam, and tazobactam in a clinical isolate of Escherichia coli.
    Blazquez J, Baquero MR, Canton R, Alos I, Baquero F.
    Antimicrob Agents Chemother; 1993 Oct 22; 37(10):2059-63. PubMed ID: 8257123
    [Abstract] [Full Text] [Related]

  • 18. Characterization of a PSE-4 mutant with different properties in relation to penicillanic acid sulfones: importance of residues 216 to 218 in class A beta-lactamases.
    Sabbagh Y, Thériault E, Sanschagrin F, Voyer N, Palzkill T, Levesque RC.
    Antimicrob Agents Chemother; 1998 Sep 22; 42(9):2319-25. PubMed ID: 9736556
    [Abstract] [Full Text] [Related]

  • 19. Exploring the inhibition of CTX-M-9 by beta-lactamase inhibitors and carbapenems.
    Bethel CR, Taracila M, Shyr T, Thomson JM, Distler AM, Hujer KM, Hujer AM, Endimiani A, Papp-Wallace K, Bonnet R, Bonomo RA.
    Antimicrob Agents Chemother; 2011 Jul 22; 55(7):3465-75. PubMed ID: 21555770
    [Abstract] [Full Text] [Related]

  • 20. OHIO-1 beta-lactamase resistant to mechanism-based inactivators.
    Bonomo RA, Currie-McCumber C, Shlaes DM.
    FEMS Microbiol Lett; 1992 Apr 01; 71(1):79-82. PubMed ID: 1320587
    [No Abstract] [Full Text] [Related]

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