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119 related items for PubMed ID: 9747464

  • 1. Chemoprotective gene transfer I: transduction of human haemopoietic progenitors with O6-benzylguanine-resistant O6-alkylguanine-DNA alkyltransferase attenuates the toxic effects of O6-alkylating agents in vitro.
    Hickson I, Fairbairn LJ, Chinnasamy N, Lashford LS, Thatcher N, Margison GP, Dexter TM, Rafferty JA.
    Gene Ther; 1998 Jun; 5(6):835-41. PubMed ID: 9747464
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  • 2. Chemoprotective gene transfer II: multilineage in vivo protection of haemopoiesis against the effects of an antitumour agent by expression of a mutant human O6-alkylguanine-DNA alkyltransferase.
    Chinnasamy N, Rafferty JA, Hickson I, Lashford LS, Longhurst SJ, Thatcher N, Margison GP, Dexter TM, Fairbairn LJ.
    Gene Ther; 1998 Jun; 5(6):842-7. PubMed ID: 9747465
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  • 4. Enhancing hemopoietic drug resistance: a rationale for reconsidering the clinical use of mitozolomide.
    Fairbairn LJ, Chinnasamy N, Lashford LS, Chinnasamy D, Rafferty JA.
    Cancer Gene Ther; 2000 Feb; 7(2):233-9. PubMed ID: 10770631
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  • 5. Protection of committed murine haemopoietic progenitors against BCNU toxicity does not predict protection of primitive, multipotent spleen colony-forming cells - implications for chemoprotective gene therapy.
    Chinnasamy N, Rafferty J, Lashford L, Chinnasamy D, Margison G, Thatcher N, Dexter T, Fairbairn L.
    Leukemia; 1999 Nov; 13(11):1776-83. PubMed ID: 10557052
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  • 6. Lentivirus-mediated expression of mutant MGMTP140K protects human CD34+ cells against the combined toxicity of O6-benzylguanine and 1,3-bis(2-chloroethyl)-nitrosourea or temozolomide.
    Chinnasamy D, Fairbairn LJ, Neuenfeldt J, Treisman JS, Hanson JP, Margison GP, Chinnasamy N.
    Hum Gene Ther; 2004 Aug; 15(8):758-69. PubMed ID: 15319033
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  • 7. Simultaneous protection of G156A methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and sensitization of tumor cells using O6-benzylguanine and temozolomide.
    Reese JS, Davis BM, Liu L, Gerson SL.
    Clin Cancer Res; 1999 Jan; 5(1):163-9. PubMed ID: 9918215
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  • 8. Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases.
    Cai Y, Wu MH, Xu-Welliver M, Pegg AE, Ludeman SM, Dolan ME.
    Cancer Res; 2000 Oct 01; 60(19):5464-9. PubMed ID: 11034089
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  • 12. O6-Benzylguanine potentiates BCNU but not busulfan toxicity in hematopoietic stem cells.
    Westerhof GR, Down JD, Blokland I, Wood M, Boudewijn A, Watson AJ, McGown AT, Ploemacher RE, Margison GP.
    Exp Hematol; 2001 May 01; 29(5):633-8. PubMed ID: 11376877
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  • 14. Human long-term culture initiating cells are sensitive to benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and protected after mutant (G156A) methylguanine methyltransferase gene transfer.
    Koç ON, Reese JS, Szekely EM, Gerson SL.
    Cancer Gene Ther; 1999 May 01; 6(4):340-8. PubMed ID: 10419052
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  • 16. Retroviral-mediated gene transduction of human alkyltransferase complementary DNA confers nitrosourea resistance to human hematopoietic progenitors.
    Allay JA, Koç ON, Davis BM, Gerson SL.
    Clin Cancer Res; 1996 Aug 01; 2(8):1353-9. PubMed ID: 9816307
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  • 17. Human mesenchymal stem cells provide stromal support for efficient CD34+ transduction.
    Reese JS, Koç ON, Gerson SL.
    J Hematother Stem Cell Res; 1999 Oct 01; 8(5):515-23. PubMed ID: 10791902
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  • 18. Retrovirus-mediated transfer of the human O6-methylguanine-DNA methyltransferase gene into a murine hematopoietic stem cell line and resistance to the toxic effects of certain alkylating agents.
    Wang G, Weiss C, Sheng P, Bresnick E.
    Biochem Pharmacol; 1996 May 03; 51(9):1221-8. PubMed ID: 8645346
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  • 20. Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: implications for drug resistance gene therapy.
    Davis BM, Roth JC, Liu L, Xu-Welliver M, Pegg AE, Gerson SL.
    Hum Gene Ther; 1999 Nov 20; 10(17):2769-78. PubMed ID: 10584923
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