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181 related items for PubMed ID: 9749838

  • 1. Site-directed mutagenesis identifies amino acid residues associated with the dehydrogenase and isomerase activities of human type I (placental) 3beta-hydroxysteroid dehydrogenase/isomerase.
    Thomas JL, Evans BW, Blanco G, Mercer RW, Mason JI, Adler S, Nash WE, Isenberg KE, Strickler RC.
    J Steroid Biochem Mol Biol; 1998 Sep; 66(5-6):327-34. PubMed ID: 9749838
    [Abstract] [Full Text] [Related]

  • 2. The engineered, cytosolic form of human type I 3beta-hydroxysteroid dehydrogenase/isomerase: purification, characterization and crystallization.
    Thomas JL, Mason JI, Blanco G, Veisaga ML.
    J Mol Endocrinol; 2001 Aug; 27(1):77-83. PubMed ID: 11463578
    [Abstract] [Full Text] [Related]

  • 3. Functional activity of 3beta-hydroxysteroid dehydrogenase/isomerase.
    Mason JI, Naville D, Evans BW, Thomas JL.
    Endocr Res; 1998 Aug; 24(3-4):549-57. PubMed ID: 9888536
    [Abstract] [Full Text] [Related]

  • 4. Creation of a fully active, cytosolic form of human type I 3beta-hydroxysteroid dehydrogenase/isomerase by the deletion of a membrane-spanning domain.
    Thomas JL, Evans BW, Blanco G, Mason JI, Strickler RC.
    J Mol Endocrinol; 1999 Oct; 23(2):231-9. PubMed ID: 10514560
    [Abstract] [Full Text] [Related]

  • 5. Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity.
    Thomas JL, Mason JI, Brandt S, Spencer BR, Norris W.
    J Biol Chem; 2002 Nov 08; 277(45):42795-801. PubMed ID: 12205101
    [Abstract] [Full Text] [Related]

  • 6. Over-expression of human type I (placental) 3 beta-hydroxy-5-ene-steroid dehydrogenase/isomerase in insect cells infected with recombinant baculovirus.
    Nash WE, Mercer RW, Blanco G, Strickler RC, Mason JI, Thomas JL.
    J Steroid Biochem Mol Biol; 1994 Sep 08; 50(5-6):235-40. PubMed ID: 7918109
    [Abstract] [Full Text] [Related]

  • 7. Structure, function and tissue-specific gene expression of 3β-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase enzymes in classical and peripheral intracrine steroidogenic tissues.
    Labrie F, Simard J, Luu-The V, Bélanger A, Pelletier G.
    J Steroid Biochem Mol Biol; 1992 Dec 08; 43(8):805-26. PubMed ID: 22217825
    [Abstract] [Full Text] [Related]

  • 8. Structure/function relationships responsible for coenzyme specificity and the isomerase activity of human type 1 3 beta-hydroxysteroid dehydrogenase/isomerase.
    Thomas JL, Duax WL, Addlagatta A, Brandt S, Fuller RR, Norris W.
    J Biol Chem; 2003 Sep 12; 278(37):35483-90. PubMed ID: 12832414
    [Abstract] [Full Text] [Related]

  • 9. Rational proteomics V: structure-based mutagenesis has revealed key residues responsible for substrate recognition and catalysis by the dehydrogenase and isomerase activities in human 3beta-hydroxysteroid dehydrogenase/isomerase type 1.
    Pletnev VZ, Thomas JL, Rhaney FL, Holt LS, Scaccia LA, Umland TC, Duax WL.
    J Steroid Biochem Mol Biol; 2006 Sep 12; 101(1):50-60. PubMed ID: 16889958
    [Abstract] [Full Text] [Related]

  • 10. Thyroid hormone regulation of perch ovarian 3beta-hydroxysteroid dehydrogenase/delta5-delta4-isomerase activity: involvement of a 52-kDa protein.
    Datta M, Nagendra Prasad RJ, Bhattacharya S.
    Gen Comp Endocrinol; 1999 Feb 12; 113(2):212-20. PubMed ID: 10082623
    [Abstract] [Full Text] [Related]

  • 11. Serine 124 completes the Tyr, Lys and Ser triad responsible for the catalysis of human type 1 3beta-hydroxysteroid dehydrogenase.
    Thomas JL, Duax WL, Addlagatta A, Scaccia LA, Frizzell KA, Carloni SB.
    J Mol Endocrinol; 2004 Aug 12; 33(1):253-61. PubMed ID: 15291757
    [Abstract] [Full Text] [Related]

  • 12. Characterization of the structure-activity relationships of rat types I and II 3 beta-hydroxysteroid dehydrogenase/delta 5 -delta 4 isomerase by site-directed mutagenesis and expression in HeLa cells.
    Simard J, de Launoit Y, Labrie F.
    J Biol Chem; 1991 Aug 15; 266(23):14842-5. PubMed ID: 1831194
    [Abstract] [Full Text] [Related]

  • 13. Molecular biology of the 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene family.
    Simard J, Ricketts ML, Gingras S, Soucy P, Feltus FA, Melner MH.
    Endocr Rev; 2005 Jun 15; 26(4):525-82. PubMed ID: 15632317
    [Abstract] [Full Text] [Related]

  • 14. Stat5-mediated regulation of the human type II 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene: activation by prolactin.
    Feltus FA, Groner B, Melner MH.
    Mol Endocrinol; 1999 Jul 15; 13(7):1084-93. PubMed ID: 10406460
    [Abstract] [Full Text] [Related]

  • 15. Differences in substrate and inhibitor kinetics of human type 1 and type 2 3beta-hydroxysteroid dehydrogenase are explained by the type 1 mutant, H156Y.
    Thomas JL, Mason JI, Brandt S, Norris W.
    Endocr Res; 2002 Nov 15; 28(4):471-5. PubMed ID: 12530651
    [Abstract] [Full Text] [Related]

  • 16. Differential regulation of Leydig cell 3beta-hydroxysteroid dehydrogenase/delta5-delta4-isomerase activity by gonadotropin and thyroid hormone in a freshwater perch, Anabas testudineus (Bloch).
    Nagendra Prasad RJ, Datta M, Bhattacharya S.
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol; 1999 Oct 15; 124(2):165-73. PubMed ID: 10622432
    [Abstract] [Full Text] [Related]

  • 17. Induction of 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase type 1 gene transcription in human breast cancer cell lines and in normal mammary epithelial cells by interleukin-4 and interleukin-13.
    Gingras S, Moriggl R, Groner B, Simard J.
    Mol Endocrinol; 1999 Jan 15; 13(1):66-81. PubMed ID: 9892013
    [Abstract] [Full Text] [Related]

  • 18. Human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase: purification from mitochondria and kinetic profiles, biophysical characterization of the purified mitochondrial and microsomal enzymes.
    Thomas JL, Myers RP, Strickler RC.
    J Steroid Biochem; 1989 Aug 15; 33(2):209-17. PubMed ID: 2770297
    [Abstract] [Full Text] [Related]

  • 19. Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads.
    Rhéaume E, Lachance Y, Zhao HF, Breton N, Dumont M, de Launoit Y, Trudel C, Luu-The V, Simard J, Labrie F.
    Mol Endocrinol; 1991 Aug 15; 5(8):1147-57. PubMed ID: 1944309
    [Abstract] [Full Text] [Related]

  • 20. Affinity radiolabeling identifies peptides associated with the isomerase activity of human type I (placental) 3beta-hydroxysteroid dehydrogenase/isomerase.
    Thomas JL, Evans BW, Strickler RC.
    Biochemistry; 1997 Jul 22; 36(29):9029-34. PubMed ID: 9220991
    [Abstract] [Full Text] [Related]

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