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Journal Abstract Search

191 related items for PubMed ID: 9750002

  • 1. Potent, stereoselective, and brain region selective modulation of second messengers in the rat brain by (+)LY354740, a novel group II metabotropic glutamate receptor agonist.
    Schoepp DD, Johnson BG, Wright RA, Salhoff CR, Monn JA.
    Naunyn Schmiedebergs Arch Pharmacol; 1998 Aug; 358(2):175-80. PubMed ID: 9750002
    [Abstract] [Full Text] [Related]

  • 2. LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors.
    Schoepp DD, Johnson BG, Wright RA, Salhoff CR, Mayne NG, Wu S, Cockerman SL, Burnett JP, Belegaje R, Bleakman D, Monn JA.
    Neuropharmacology; 1997 Jan; 36(1):1-11. PubMed ID: 9144636
    [Abstract] [Full Text] [Related]

  • 3. The novel metabotropic glutamate receptor agonist 2R,4R-APDC potentiates stimulation of phosphoinositide hydrolysis in the rat hippocampus by 3,5-dihydroxyphenylglycine: evidence for a synergistic interaction between group 1 and group 2 receptors.
    Schoepp DD, Salhoff CR, Wright RA, Johnson BG, Burnett JP, Mayne NG, Belagaje R, Wu S, Monn JA.
    Neuropharmacology; 1996 Jan; 35(12):1661-72. PubMed ID: 9076745
    [Abstract] [Full Text] [Related]

  • 4. Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors.
    Monn JA, Valli MJ, Massey SM, Hansen MM, Kress TJ, Wepsiec JP, Harkness AR, Grutsch JL, Wright RA, Johnson BG, Andis SL, Kingston A, Tomlinson R, Lewis R, Griffey KR, Tizzano JP, Schoepp DD.
    J Med Chem; 1999 Mar 25; 42(6):1027-40. PubMed ID: 10090786
    [Abstract] [Full Text] [Related]

  • 5. Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039).
    Rorick-Kehn LM, Johnson BG, Burkey JL, Wright RA, Calligaro DO, Marek GJ, Nisenbaum ES, Catlow JT, Kingston AE, Giera DD, Herin MF, Monn JA, McKinzie DL, Schoepp DD.
    J Pharmacol Exp Ther; 2007 Apr 25; 321(1):308-17. PubMed ID: 17204749
    [Abstract] [Full Text] [Related]

  • 6. Effect of metabotropic glutamate receptor activation on receptor-mediated cyclic AMP responses in primary cultures of rat striatal neurones.
    Cartmell J, Goepfert F, Knoflach F, Pink JR, Bleuel Z, Richards JG, Schaffhauser H, Kemp JA, Wichmann J, Mutel V.
    Brain Res; 1998 Apr 27; 791(1-2):191-9. PubMed ID: 9593890
    [Abstract] [Full Text] [Related]

  • 7. Differentiation of group 2 and group 3 metabotropic glutamate receptor cAMP responses in the rat hippocampus.
    Wright RA, Schoepp DD.
    Eur J Pharmacol; 1996 Feb 22; 297(3):275-82. PubMed ID: 8666060
    [Abstract] [Full Text] [Related]

  • 8. Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice.
    Linden AM, Shannon H, Baez M, Yu JL, Koester A, Schoepp DD.
    Psychopharmacology (Berl); 2005 Apr 22; 179(1):284-91. PubMed ID: 15619115
    [Abstract] [Full Text] [Related]

  • 9. Regulation of phosphoinositide turnover in neonatal rat cerebral cortex by group I- and II- selective metabotropic glutamate receptor agonists.
    Mistry R, Golding N, Challiss RA.
    Br J Pharmacol; 1998 Feb 22; 123(3):581-9. PubMed ID: 9504400
    [Abstract] [Full Text] [Related]

  • 10. Changes in rat serum corticosterone after treatment with metabotropic glutamate receptor agonists or antagonists.
    Johnson MP, Kelly G, Chamberlain M.
    J Neuroendocrinol; 2001 Aug 22; 13(8):670-7. PubMed ID: 11489083
    [Abstract] [Full Text] [Related]

  • 11. Metabotropic glutamate autoreceptors of the mGlu(5) subtype positively modulate neuronal glutamate release in the rat forebrain in vitro.
    Thomas LS, Jane DE, Harris JR, Croucher MJ.
    Neuropharmacology; 2000 Jul 10; 39(9):1554-66. PubMed ID: 10854900
    [Abstract] [Full Text] [Related]

  • 12. Influence of metabotropic glutamate receptor agonists on the inhibitory effects of adenosine A1 receptor activation in the rat hippocampus.
    de Mendonça A, Ribeiro JA.
    Br J Pharmacol; 1997 Aug 10; 121(8):1541-8. PubMed ID: 9283686
    [Abstract] [Full Text] [Related]

  • 13. 3,5-dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus.
    Schoepp DD, Goldsworthy J, Johnson BG, Salhoff CR, Baker SR.
    J Neurochem; 1994 Aug 10; 63(2):769-72. PubMed ID: 8035201
    [Abstract] [Full Text] [Related]

  • 14. Characterisation of the actions of group I metabotropic glutamate receptor subtype selective ligands on excitatory amino acid release and sodium-dependent re-uptake in rat cerebrocortical minislices.
    Fazal A, Parker F, Palmer AM, Croucher MJ.
    J Neurochem; 2003 Sep 10; 86(6):1346-58. PubMed ID: 12950444
    [Abstract] [Full Text] [Related]

  • 15. The anxiolytic action of mGlu2/3 receptor agonist, LY354740, in the fear-potentiated startle model in rats is mechanistically distinct from diazepam.
    Tizzano JP, Griffey KI, Schoepp DD.
    Pharmacol Biochem Behav; 2002 Sep 10; 73(2):367-74. PubMed ID: 12117591
    [Abstract] [Full Text] [Related]

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  • 17. Phosphoinositide hydrolysis in vivo with group I metabotropic glutamate receptor agonists.
    Johnson MP, Chamberlain M, Kelly GM.
    Brain Res; 1999 Mar 13; 821(2):539-45. PubMed ID: 10064844
    [Abstract] [Full Text] [Related]

  • 18. Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR.
    Sanger H, Hanna L, Colvin EM, Grubisha O, Ursu D, Heinz BA, Findlay JD, Vivier RG, Sher E, Lodge D, Monn JA, Broad LM.
    Neuropharmacology; 2013 Mar 13; 66():264-73. PubMed ID: 22659090
    [Abstract] [Full Text] [Related]

  • 19. The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats.
    Cartmell J, Monn JA, Schoepp DD.
    J Pharmacol Exp Ther; 1999 Oct 13; 291(1):161-70. PubMed ID: 10490900
    [Abstract] [Full Text] [Related]

  • 20. (S)-4-carboxy-3-hydroxyphenylglycine activates phosphatidyl inositol linked metabotropic glutamate receptors in different brain regions of the neonatal rat.
    Sacaan AI, Santori EM, Rao TS.
    Neurochem Int; 1998 Jan 13; 32(1):77-85. PubMed ID: 9460705
    [Abstract] [Full Text] [Related]

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