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Journal Abstract Search

331 related items for PubMed ID: 9753436

  • 1. Synthesis and characterization of more potent analogues of hirudin fragment 1-47 containing non-natural amino acids.
    De Filippis V, Quarzago D, Vindigni A, Di Cera E, Fontana A.
    Biochemistry; 1998 Sep 29; 37(39):13507-15. PubMed ID: 9753436
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  • 3. Probing the hirudin-thrombin interaction by incorporation of noncoded amino acids and molecular dynamics simulation.
    De Filippis V, Colombo G, Russo I, Spadari B, Fontana A.
    Biochemistry; 2002 Nov 19; 41(46):13556-69. PubMed ID: 12427016
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  • 4. Core domain of hirudin from the leech Hirudinaria manillensis: chemical synthesis, purification, and characterization of a Trp3 analog of fragment 1-47.
    De Filippis V, Vindigni A, Altichieri L, Fontana A.
    Biochemistry; 1995 Jul 25; 34(29):9552-64. PubMed ID: 7626625
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  • 6. Nonpolar interactions of thrombin and its inhibitors at the fibrinogen recognition exosite: thermodynamic analysis.
    Cheng Y, Slon-Usakiewicz JJ, Wang J, Purisima EO, Konishi Y.
    Biochemistry; 1996 Oct 08; 35(40):13021-9. PubMed ID: 8855937
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  • 7. Rational design of true hirudin mimetics: synthesis and characterization of multisite-directed alpha-thrombin inhibitors.
    Lombardi A, Nastri F, Della Morte R, Rossi A, De Rosa A, Staiano N, Pedone C, Pavone V.
    J Med Chem; 1996 May 10; 39(10):2008-17. PubMed ID: 8642559
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  • 9. Calculation of relative binding free energies and configurational entropies: a structural and thermodynamic analysis of the nature of non-polar binding of thrombin inhibitors based on hirudin55-65.
    Wang J, Szewczuk Z, Yue SY, Tsuda Y, Konishi Y, Purisima EO.
    J Mol Biol; 1995 Oct 27; 253(3):473-92. PubMed ID: 7473728
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  • 11. Effect of the hirudin carboxy-terminal peptide 54-65 on the interaction of thrombin with platelets.
    Jandrot-Perrus M, Huisse MG, Krstenansky JL, Bezeaud A, Guillin MC.
    Thromb Haemost; 1991 Sep 02; 66(3):300-5. PubMed ID: 1746000
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  • 12. Molecular design and characterization of an alpha-thrombin inhibitor containing a novel P1 moiety.
    Malikayil JA, Burkhart JP, Schreuder HA, Broersma RJ, Tardif C, Kutcher LW, Mehdi S, Schatzman GL, Neises B, Peet NP.
    Biochemistry; 1997 Feb 04; 36(5):1034-40. PubMed ID: 9033393
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  • 13. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
    Costanzo MJ, Almond HR, Hecker LR, Schott MR, Yabut SC, Zhang HC, Andrade-Gordon P, Corcoran TW, Giardino EC, Kauffman JA, Lewis JM, de Garavilla L, Haertlein BJ, Maryanoff BE.
    J Med Chem; 2005 Mar 24; 48(6):1984-2008. PubMed ID: 15771442
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  • 15. Structure-activity relationships of recombinant hirudins.
    Stürzebecher J, Walsmann P.
    Semin Thromb Hemost; 1991 Apr 24; 17(2):94-8. PubMed ID: 1771418
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  • 16. Potent bivalent thrombin inhibitors: replacement of the scissile peptide bond at P(1)-P(1)' with arginyl ketomethylene isosteres.
    Steinmetzer T, Zhu BY, Konishi Y.
    J Med Chem; 1999 Aug 12; 42(16):3109-15. PubMed ID: 10447955
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  • 17. The world of beta- and gamma-peptides comprised of homologated proteinogenic amino acids and other components.
    Seebach D, Beck AK, Bierbaum DJ.
    Chem Biodivers; 2004 Aug 12; 1(8):1111-239. PubMed ID: 17191902
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  • 18. From natural to synthetic multisite thrombin inhibitors.
    Lombardi A, De Simone G, Galdiero S, Staiano N, Nastri F, Pavone V.
    Biopolymers; 1999 Aug 12; 51(1):19-39. PubMed ID: 10380350
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  • 19. Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6.
    Zdanov A, Wu S, DiMaio J, Konishi Y, Li Y, Wu X, Edwards BF, Martin PD, Cygler M.
    Proteins; 1993 Nov 12; 17(3):252-65. PubMed ID: 8272424
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  • 20. Molecular dynamics simulations of thrombin inhibitors at the S' subsites of thrombin.
    Yue SY, Konishi Y.
    Drug Des Discov; 1994 Jul 12; 12(1):1-17. PubMed ID: 7578804
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