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Journal Abstract Search

211 related items for PubMed ID: 9771954

  • 1. Effect of adding the topoisomerase I poison 7-ethyl-10-hydroxycamptothecin (SN-38) to 5-fluorouracil and folinic acid in HCT-8 cells: elevated dTTP pools and enhanced cytotoxicity.
    Mullany S, Svingen PA, Kaufmann SH, Erlichman C.
    Cancer Chemother Pharmacol; 1998; 42(5):391-9. PubMed ID: 9771954
    [Abstract] [Full Text] [Related]

  • 2. Determinants of cytotoxicity with prolonged exposure to fluorouracil in human colon cancer cells.
    Ren Q, Van Groeningen CJ, Hardcastle A, Aherne GW, Geoffroy F, Allegra CJ, Johnston PG, Grem JL.
    Oncol Res; 1997; 9(2):77-88. PubMed ID: 9167189
    [Abstract] [Full Text] [Related]

  • 3. Combination of 5-fluorouracil and irinotecan on modulation of thymidylate synthase and topoisomerase I expression and cell cycle regulation in human colon cancer LoVo cells: clinical relevance.
    Xu JM, Azzariti A, Tommasi S, Lacalamita R, Colucci G, Johnston PG, Church SW, Paradiso A.
    Clin Colorectal Cancer; 2002 Nov; 2(3):182-8. PubMed ID: 12482336
    [Abstract] [Full Text] [Related]

  • 4. The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux.
    Erlichman C, Boerner SA, Hallgren CG, Spieker R, Wang XY, James CD, Scheffer GL, Maliepaard M, Ross DD, Bible KC, Kaufmann SH.
    Cancer Res; 2001 Jan 15; 61(2):739-48. PubMed ID: 11212277
    [Abstract] [Full Text] [Related]

  • 5. Effect of interferon on 5-fluorouracil-induced perturbations in pools of deoxynucleotide triphosphates and DNA strand breaks.
    Wadler S, Horowitz R, Mao X, Schwartz EL.
    Cancer Chemother Pharmacol; 1996 Jan 15; 38(6):529-35. PubMed ID: 8823494
    [Abstract] [Full Text] [Related]

  • 6. Comparative cytotoxicity of folate-based inhibitors of thymidylate synthase and 5-fluorouracil +/- leucovorin in MGH-U1 cells.
    Erlichman C, Mitrovski B.
    Cancer Chemother Pharmacol; 1994 Jan 15; 34(1):51-6. PubMed ID: 8174202
    [Abstract] [Full Text] [Related]

  • 7. Increased anticancer activity of the thymidylate synthase inhibitor BGC9331 combined with the topoisomerase I inhibitor SN-38 in human colorectal and breast cancer cells: induction of apoptosis and ROCK cleavage through caspase-3-dependent and -independent mechanisms.
    Coudray AM, Louvet C, Kornprobst M, Raymond E, André T, Tournigand C, Faivre S, De Gramont A, Larsen AK, Gespach C.
    Int J Oncol; 2005 Aug 15; 27(2):553-61. PubMed ID: 16010439
    [Abstract] [Full Text] [Related]

  • 8. Synergistic effects of topoisomerase I inhibitor, 7-ethyl-10-hydroxycamptothecin, and irradiation in a cisplatin-resistant human small cell lung cancer cell line.
    Kohara H, Tabata M, Kiura K, Ueoka H, Kawata K, Chikamori M, Aoe K, Chikamori K, Matsushita A, Harada M.
    Clin Cancer Res; 2002 Jan 15; 8(1):287-92. PubMed ID: 11801571
    [Abstract] [Full Text] [Related]

  • 9. Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil.
    Nakajima TE, Yasunaga M, Kano Y, Koizumi F, Kato K, Hamaguchi T, Yamada Y, Shirao K, Shimada Y, Matsumura Y.
    Int J Cancer; 2008 May 01; 122(9):2148-53. PubMed ID: 18196580
    [Abstract] [Full Text] [Related]

  • 10. Cellular interactions of 5-fluorouracil and the camptothecin analogue CPT-11 (irinotecan) in a human colorectal carcinoma cell line.
    Guichard S, Hennebelle I, Bugat R, Canal P.
    Biochem Pharmacol; 1998 Mar 01; 55(5):667-76. PubMed ID: 9515577
    [Abstract] [Full Text] [Related]

  • 11. Cellular pharmacology of the combination of the DNA topoisomerase I inhibitor SN-38 and the diaminocyclohexane platinum derivative oxaliplatin.
    Zeghari-Squalli N, Raymond E, Cvitkovic E, Goldwasser F.
    Clin Cancer Res; 1999 May 01; 5(5):1189-96. PubMed ID: 10353756
    [Abstract] [Full Text] [Related]

  • 12. Combination of irinotecan (CPT11) and 5-fluorouracil with an analysis of cellular determinants of drug activity.
    Pavillard V, Formento P, Rostagno P, Formento JL, Fischel JL, Francoual M, Etienne MC, Milano G.
    Biochem Pharmacol; 1998 Nov 15; 56(10):1315-22. PubMed ID: 9825730
    [Abstract] [Full Text] [Related]

  • 13. Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.
    van Triest B, Pinedo HM, van Hensbergen Y, Smid K, Telleman F, Schoenmakers PS, van der Wilt CL, van Laar JA, Noordhuis P, Jansen G, Peters GJ.
    Clin Cancer Res; 1999 Mar 15; 5(3):643-54. PubMed ID: 10100718
    [Abstract] [Full Text] [Related]

  • 14. Biochemical modulation of 5-fluorouracil with or without leucovorin by a low dose of brequinar in MGH-U1 cells.
    Chen TL, Erlichman C.
    Cancer Chemother Pharmacol; 1992 Mar 15; 30(5):370-6. PubMed ID: 1380407
    [Abstract] [Full Text] [Related]

  • 15. The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition.
    Webley SD, Welsh SJ, Jackman AL, Aherne GW.
    Br J Cancer; 2001 Aug 03; 85(3):446-52. PubMed ID: 11487279
    [Abstract] [Full Text] [Related]

  • 16. Sequential treatment with SN-38 followed by 5-fluorouracil shows synergistic cytotoxic activity in small cell lung cancer cells.
    Takeda K, Suyama H, Igishi T, Shigeoka Y, Matsumoto S, Yamasaki A, Hashimoto K, Sumikawa T, Morita M, Ueda Y, Shimizu E.
    Oncol Rep; 2008 Apr 03; 19(4):945-51. PubMed ID: 18357380
    [Abstract] [Full Text] [Related]

  • 17. Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism.
    Peters GJ, Backus HH, Freemantle S, van Triest B, Codacci-Pisanelli G, van der Wilt CL, Smid K, Lunec J, Calvert AH, Marsh S, McLeod HL, Bloemena E, Meijer S, Jansen G, van Groeningen CJ, Pinedo HM.
    Biochim Biophys Acta; 2002 Jul 18; 1587(2-3):194-205. PubMed ID: 12084461
    [Abstract] [Full Text] [Related]

  • 18. N-(phosphonacetyl)-L-aspartate synergistically enhances the cytotoxicity of 5-fluorouracil/interferon-alpha-2a against human colon cancer cell lines.
    Wadler S, Mao X, Bajaj R, Hallam S, Schwartz EL.
    Mol Pharmacol; 1993 Nov 18; 44(5):1070-6. PubMed ID: 8246910
    [Abstract] [Full Text] [Related]

  • 19. Schedule-dependent synergism between raltitrexed and irinotecan in human colon cancer cells in vitro.
    Aschele C, Baldo C, Sobrero AF, Debernardis D, Bornmann WG, Bertino JR.
    Clin Cancer Res; 1998 May 18; 4(5):1323-30. PubMed ID: 9607593
    [Abstract] [Full Text] [Related]

  • 20. Measurement of deoxyuridine triphosphate and thymidine triphosphate in the extracts of thymidylate synthase-inhibited cells using a modified DNA polymerase assay.
    Horowitz RW, Zhang H, Schwartz EL, Ladner RD, Wadler S.
    Biochem Pharmacol; 1997 Sep 01; 54(5):635-8. PubMed ID: 9337081
    [Abstract] [Full Text] [Related]

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