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230 related items for PubMed ID: 9779586

  • 1. Sterol synthesis. Synthesis of 3 beta-hydroxy-25,26,26,26,27,27,27-heptafluorocholest-5-en-7-one and its effects on HMG-CoA reductase activity in Chinese hamster ovary cells, on ACAT activity in rat jejunal microsomes, and serum cholesterol levels in rats.
    Carroll JN, Pinkerton FD, Su X, Gerst N, Wilson WK, Schroepfer GJ.
    Chem Phys Lipids; 1998 Aug; 94(2):209-25. PubMed ID: 9779586
    [Abstract] [Full Text] [Related]

  • 2. Inhibitors of sterol synthesis. Chemical synthesis and properties of 3 beta-hydroxy-25,26,26,26,27,27,27-heptafluoro-5 alpha-cholest-8(14)-en-15-one and 25,26,26,26,27,27,27-heptafluorocholesterol and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells.
    Swaminathan S, Wilson WK, Pinkerton FD, Gerst N, Ramser M, Schroepfer GJ.
    J Lipid Res; 1993 Oct; 34(10):1805-23. PubMed ID: 8245728
    [Abstract] [Full Text] [Related]

  • 3. Regulation of ovarian cholesterol metabolism: control of 3-hydroxy-3-methylglutaryl coenzyme A reductase and acyl coenzyme A:cholesterol acyltransferase.
    Schuler LA, Toaff ME, Strauss JF.
    Endocrinology; 1981 Apr; 108(4):1476-86. PubMed ID: 7472277
    [Abstract] [Full Text] [Related]

  • 4. Inhibitors of sterol synthesis: effects of a 7 alpha-alkyl analog of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells and on serum cholesterol levels and other parameters in rats.
    Siddiqui AU, Gerst N, Kim LJ, Pinkerton FD, Kisic A, Wilson WK, Schroepfer GJ.
    Chem Phys Lipids; 1994 Apr 19; 70(2):163-78. PubMed ID: 8033288
    [Abstract] [Full Text] [Related]

  • 5. Inhibitors of sterol synthesis. Effects of dietary 5 alpha-cholest-8(14)-en-3 beta-ol-15-one on early enzymes in hepatic cholesterol biosynthesis.
    Miller LR, Raulston DL, Schroepfer GJ.
    Chem Phys Lipids; 1988 Jul 19; 47(3):177-86. PubMed ID: 2901919
    [Abstract] [Full Text] [Related]

  • 6. Inhibitors of sterol synthesis. Chemical synthesis, structure, and biological activities of (25R)-3 beta,26-dihydroxy-5 alpha-cholest-8(14)-en-15-one, a metabolite of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one.
    Kim HS, Wilson WK, Needleman DH, Pinkerton FD, Wilson DK, Quiocho FA, Schroepfer GJ.
    J Lipid Res; 1989 Feb 19; 30(2):247-61. PubMed ID: 2715729
    [Abstract] [Full Text] [Related]

  • 7. Regulation of acylcoenzyme A. Cholesterol acyltransferase and 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by lipoproteins in the intestine of parabiont rats.
    Purdy BH, Field FJ.
    J Clin Invest; 1984 Aug 19; 74(2):351-7. PubMed ID: 6746898
    [Abstract] [Full Text] [Related]

  • 8. Inhibitors of sterol synthesis: synthesis and spectral properties of derivatives of 3 beta-hydroxy-25,26,26,26,27,27,27-heptafluoro-5 alpha-cholest-8(14)-en-15-one fluorinated at carbon 7 or carbon 9 and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells.
    Siddiqui AU, Swaminathan S, Pinkerton FD, Gerst N, Wilson WK, Choi H, Schroephfer GJ.
    Chem Phys Lipids; 1994 Jun 24; 72(1):59-75. PubMed ID: 7923480
    [Abstract] [Full Text] [Related]

  • 9. Inhibitors of sterol synthesis. Studies of the metabolism of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one in Chinese hamster ovary cells and its effects on activities of early enzymes in cholesterol biosynthesis.
    Pajewski TN, Pinkerton FD, Miller LR, Schroepfer GJ.
    Chem Phys Lipids; 1988 Oct 24; 48(3-4):153-68. PubMed ID: 2907421
    [Abstract] [Full Text] [Related]

  • 10. Inhibitors of sterol synthesis: 3 beta-hydroxy-25,26,26,26,27,27,27- heptafluoro-5 alpha-cholestan-15-one, an analog of a potent hypocholesterolemic agent in which its major metabolism is blocked.
    Swaminathan S, Siddiqui AU, Pinkerton FD, Gerst N, Wilson WK, Schroepfer GJ.
    Biochem Biophys Res Commun; 1994 May 30; 201(1):168-73. PubMed ID: 8198571
    [Abstract] [Full Text] [Related]

  • 11. Inhibitors of sterol synthesis. Metabolism-based design and construction of a new analog of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one and its effects in cultured mammalian cells and in rats.
    Swaminathan S, Siddiqui AU, Gerst N, Pinkerton FD, Kisic A, Kim LJ, Wilson WK, Schroepfer GJ.
    J Lipid Res; 1995 Apr 30; 36(4):767-86. PubMed ID: 7616123
    [Abstract] [Full Text] [Related]

  • 12. Inhibitors of sterol synthesis. Chemical synthesis of 7 alpha-ethyl and 16 alpha-ethyl derivatives of delta 8(14)-15-oxygenated sterols and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase in CHO-K1 cells.
    Kim HS, Wilson WK, Kirkpatrick ND, Pinkerton FD, Swaminathan S, Hylarides MD, Schroepfer GJ.
    Chem Phys Lipids; 1992 Jul 30; 62(1):55-67. PubMed ID: 1423803
    [Abstract] [Full Text] [Related]

  • 13. Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase by 15 alpha-fluorolanost-7-en-3 beta-ol. A mechanism-based inhibitor of cholesterol biosynthesis.
    Trzaskos JM, Magolda RL, Favata MF, Fischer RT, Johnson PR, Chen HW, Ko SS, Leonard DA, Gaylor JL.
    J Biol Chem; 1993 Oct 25; 268(30):22591-9. PubMed ID: 7693673
    [Abstract] [Full Text] [Related]

  • 14. Inhibitors of sterol synthesis. Chemical syntheses and spectral properties of 26-oxygenated derivatives of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells.
    Siddiqui AU, Wilson WK, Ruecker KE, Pinkerton FD, Schroepfer GJ.
    Chem Phys Lipids; 1992 Nov 25; 63(1-2):77-90. PubMed ID: 1486662
    [Abstract] [Full Text] [Related]

  • 15. Cholesterol-lowering activity of naringenin via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase and acyl coenzyme A:cholesterol acyltransferase in rats.
    Lee SH, Park YB, Bae KH, Bok SH, Kwon YK, Lee ES, Choi MS.
    Ann Nutr Metab; 1999 Nov 25; 43(3):173-80. PubMed ID: 10545673
    [Abstract] [Full Text] [Related]

  • 16. Mechanisms for cholesterol homeostasis in rat jejunal mucosa: effects of cholesterol, sitosterol, and lovastatin.
    Nguyen LB, Shefer S, Salen G, Tint GS, Ruiz F, Bullock J.
    J Lipid Res; 2001 Feb 25; 42(2):195-200. PubMed ID: 11181748
    [Abstract] [Full Text] [Related]

  • 17. Cholesterol-lowering effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on cholesterol diet-fed rats and rabbits.
    Azuma Y, Kawasaki T, Ikemoto K, Obata K, Ohno K, Sajiki N, Yamada T, Yamasaki M, Nobuhara Y.
    Jpn J Pharmacol; 1998 Nov 25; 78(3):355-64. PubMed ID: 9869270
    [Abstract] [Full Text] [Related]

  • 18. On the mechanism of regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and of acyl coenzyme A:cholesterol acyltransferase by dietary fat.
    Mitropoulos KA, Venkatesan S, Balasubramaniam S.
    Biochim Biophys Acta; 1980 Aug 11; 619(2):247-57. PubMed ID: 7407210
    [Abstract] [Full Text] [Related]

  • 19. Inhibitors of sterol synthesis. A highly efficient and specific side-chain oxidation of 3 beta-acetoxy-5 alpha-cholest-8(14)-en-15-one for construction of metabolites and analogs of the 15-ketosterol.
    Herz JE, Swaminathan S, Pinkerton FD, Wilson WK, Schroepfer GJ.
    J Lipid Res; 1992 Apr 11; 33(4):579-98. PubMed ID: 1527481
    [Abstract] [Full Text] [Related]

  • 20. Inhibitors of sterol synthesis. Synthesis and spectral properties of 3 beta-hydroxy-24-dimethylamino-5 alpha-chol-8(14)-en-15-one and its effects on HMG-CoA reductase activity in CHO-K1 cells.
    Herz JE, Wilson WK, Pinkerton FD, Schroepfer GJ.
    Chem Phys Lipids; 1991 Nov 11; 60(1):61-9. PubMed ID: 1813179
    [Abstract] [Full Text] [Related]

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