These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
2. On the optimization of hydrophobic and hydrophilic substituent interactions of 2,4-diamino-5-(substituted-benzyl)pyrimidines with dihydrofolate reductase. Selassie CD, Li RL, Poe M, Hansch C. J Med Chem; 1991 Jan; 34(1):46-54. PubMed ID: 1899453 [Abstract] [Full Text] [Related]
4. On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships. Selassie CD, Fang ZX, Li RL, Hansch C, Debnath G, Klein TE, Langridge R, Kaufman BT. J Med Chem; 1989 Aug; 32(8):1895-905. PubMed ID: 2502631 [Abstract] [Full Text] [Related]
13. Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent. Gangjee A, Yu J, McGuire JJ, Cody V, Galitsky N, Kisliuk RL, Queener SF. J Med Chem; 2000 Oct 19; 43(21):3837-51. PubMed ID: 11052789 [Abstract] [Full Text] [Related]