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Journal Abstract Search

144 related items for PubMed ID: 9806902

  • 1. An aggrecan-degrading activity associated with chondrocyte membranes.
    Billington CJ, Clark IM, Cawston TE.
    Biochem J; 1998 Nov 15; 336 ( Pt 1)(Pt 1):207-12. PubMed ID: 9806902
    [Abstract] [Full Text] [Related]

  • 2. The interglobular domain of cartilage aggrecan is cleaved by hemorrhagic metalloproteinase HT-d (atrolysin C) at the matrix metalloproteinase and aggrecanase sites.
    Tortorella MD, Pratta MA, Fox JW, Arner EC.
    J Biol Chem; 1998 Mar 06; 273(10):5846-50. PubMed ID: 9488721
    [Abstract] [Full Text] [Related]

  • 3. Mutations in the interglobular domain of aggrecan alter matrix metalloproteinase and aggrecanase cleavage patterns. Evidence that matrix metalloproteinase cleavage interferes with aggrecanase activity.
    Mercuri FA, Maciewicz RA, Tart J, Last K, Fosang AJ.
    J Biol Chem; 2000 Oct 20; 275(42):33038-45. PubMed ID: 11032846
    [Abstract] [Full Text] [Related]

  • 4. Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan.
    Büttner FH, Hughes CE, Margerie D, Lichte A, Tschesche H, Caterson B, Bartnik E.
    Biochem J; 1998 Jul 01; 333 ( Pt 1)(Pt 1):159-65. PubMed ID: 9639575
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  • 5. Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain.
    Lark MW, Gordy JT, Weidner JR, Ayala J, Kimura JH, Williams HR, Mumford RA, Flannery CR, Carlson SS, Iwata M.
    J Biol Chem; 1995 Feb 10; 270(6):2550-6. PubMed ID: 7852317
    [Abstract] [Full Text] [Related]

  • 6. Chondrocyte-mediated catabolism of aggrecan: aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine.
    Sandy JD, Gamett D, Thompson V, Verscharen C.
    Biochem J; 1998 Oct 01; 335 ( Pt 1)(Pt 1):59-66. PubMed ID: 9742213
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  • 7. Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.
    Little CB, Flannery CR, Hughes CE, Mort JS, Roughley PJ, Dent C, Caterson B.
    Biochem J; 1999 Nov 15; 344 Pt 1(Pt 1):61-8. PubMed ID: 10548534
    [Abstract] [Full Text] [Related]

  • 8. Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan.
    Fosang AJ, Last K, Neame PJ, Murphy G, Knäuper V, Tschesche H, Hughes CE, Caterson B, Hardingham TE.
    Biochem J; 1994 Dec 01; 304 ( Pt 2)(Pt 2):347-51. PubMed ID: 7998967
    [Abstract] [Full Text] [Related]

  • 9. Cleavage of native cartilage aggrecan by neutrophil collagenase (MMP-8) is distinct from endogenous cleavage by aggrecanase.
    Arner EC, Decicco CP, Cherney R, Tortorella MD.
    J Biol Chem; 1997 Apr 04; 272(14):9294-9. PubMed ID: 9083065
    [Abstract] [Full Text] [Related]

  • 10. Truncation of the amino-terminus of the recombinant aggrecan rAgg1mut leads to reduced cleavage at the aggrecanase site. Efficient aggrecanase catabolism may depend on multiple substrate interactions.
    Hörber C, Büttner FH, Kern C, Schmiedeknecht G, Bartnik E.
    Matrix Biol; 2000 Nov 04; 19(6):533-43. PubMed ID: 11068207
    [Abstract] [Full Text] [Related]

  • 11. The 45 kDa collagen-binding fragment of fibronectin induces matrix metalloproteinase-13 synthesis by chondrocytes and aggrecan degradation by aggrecanases.
    Stanton H, Ung L, Fosang AJ.
    Biochem J; 2002 May 15; 364(Pt 1):181-90. PubMed ID: 11988091
    [Abstract] [Full Text] [Related]

  • 12. Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro.
    Hughes CE, Caterson B, Fosang AJ, Roughley PJ, Mort JS.
    Biochem J; 1995 Feb 01; 305 ( Pt 3)(Pt 3):799-804. PubMed ID: 7531436
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  • 16. Cyclosporin A inhibition of aggrecanase-mediated proteoglycan catabolism in articular cartilage.
    Little CB, Hughes CE, Curtis CL, Jones SA, Caterson B, Flannery CR.
    Arthritis Rheum; 2002 Jan 01; 46(1):124-9. PubMed ID: 11817583
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  • 17. "Aggrecanase" activity is implicated in tumour necrosis factor alpha mediated cartilage aggrecan breakdown but is not detected by an in vitro assay.
    Buttle DJ, Fowles A, Ilic MZ, Handley CJ.
    Mol Pathol; 1997 Jun 01; 50(3):153-9. PubMed ID: 9292151
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  • 19. Chondrocyte-mediated catabolism of aggrecan: evidence for a glycosylphosphatidylinositol-linked protein in the aggrecanase response to interleukin-1 or retinoic acid.
    Sandy JD, Thompson V, Verscharen C, Gamett D.
    Arch Biochem Biophys; 1999 Jul 15; 367(2):258-64. PubMed ID: 10395742
    [Abstract] [Full Text] [Related]

  • 20. Coincubation of bovine synovial or capsular tissue with cartilage generates a soluble "Aggrecanase" activity.
    Vankemmelbeke MN, Ilic MZ, Handley CJ, Knight CG, Buttle DJ.
    Biochem Biophys Res Commun; 1999 Feb 24; 255(3):686-91. PubMed ID: 10049771
    [Abstract] [Full Text] [Related]

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