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387 related items for PubMed ID: 9808574

  • 1. Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53.
    Byrd JC, Shinn C, Waselenko JK, Fuchs EJ, Lehman TA, Nguyen PL, Flinn IW, Diehl LF, Sausville E, Grever MR.
    Blood; 1998 Nov 15; 92(10):3804-16. PubMed ID: 9808574
    [Abstract] [Full Text] [Related]

  • 2. UCN-01 induces cytotoxicity toward human CLL cells through a p53-independent mechanism.
    Byrd JC, Shinn C, Willis CR, Flinn IW, Lehman T, Sausville E, Lucas D, Grever MR.
    Exp Hematol; 2001 Jun 15; 29(6):703-8. PubMed ID: 11378265
    [Abstract] [Full Text] [Related]

  • 3. Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway.
    Alonso M, Tamasdan C, Miller DC, Newcomb EW.
    Mol Cancer Ther; 2003 Feb 15; 2(2):139-50. PubMed ID: 12589031
    [Abstract] [Full Text] [Related]

  • 4. P53, MDM-2, BAX and BCL-2 and drug resistance in chronic lymphocytic leukemia.
    Johnston JB, Daeninck P, Verburg L, Lee K, Williams G, Israels LG, Mowat MR, Begleiter A.
    Leuk Lymphoma; 1997 Aug 15; 26(5-6):435-49. PubMed ID: 9389352
    [Abstract] [Full Text] [Related]

  • 5. Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukaemia.
    Pepper C, Thomas A, Hoy T, Fegan C, Bentley P.
    Br J Haematol; 2001 Jul 15; 114(1):70-7. PubMed ID: 11472347
    [Abstract] [Full Text] [Related]

  • 6. The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism.
    Pei XY, Dai Y, Grant S.
    Mol Cancer Ther; 2004 Dec 15; 3(12):1513-24. PubMed ID: 15634644
    [Abstract] [Full Text] [Related]

  • 7. Flavopiridol induces apoptosis in B-cell chronic lymphocytic leukaemia cells through a p38 and ERK MAP kinase-dependent mechanism.
    Pepper C, Thomas A, Fegan C, Hoy T, Bentley P.
    Leuk Lymphoma; 2003 Feb 15; 44(2):337-42. PubMed ID: 12688354
    [Abstract] [Full Text] [Related]

  • 8. Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death.
    Chen R, Keating MJ, Gandhi V, Plunkett W.
    Blood; 2005 Oct 01; 106(7):2513-9. PubMed ID: 15972445
    [Abstract] [Full Text] [Related]

  • 9. Flavopiridol downregulates the expression of both the inducible NO synthase and p27(kip1) in malignant cells from B-cell chronic lymphocytic leukemia.
    Billard C, Kern C, Tang R, Ajchenbaum-Cymbalista F, Kolb JP.
    Leukemia; 2003 Dec 01; 17(12):2435-43. PubMed ID: 14523476
    [Abstract] [Full Text] [Related]

  • 10. Drug-induced apoptosis in chronic lymphocytic leukemia.
    Stoetzer OJ, Pogrebniak A, Scholz M, Pelka-Fleischer R, Gullis E, Darsow M, Nüssler V, Wilmanns W.
    Leukemia; 1999 Nov 01; 13(11):1873-80. PubMed ID: 10557065
    [Abstract] [Full Text] [Related]

  • 11. Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia.
    Kitada S, Zapata JM, Andreeff M, Reed JC.
    Blood; 2000 Jul 15; 96(2):393-7. PubMed ID: 10887097
    [Abstract] [Full Text] [Related]

  • 12. Leukemic and non-leukemic lymphocytes from patients with Li Fraumeni syndrome demonstrate loss of p53 function, Bcl-2 family dysregulation and intrinsic resistance to conventional chemotherapeutic drugs but not flavopiridol.
    Pepper C, Thomas A, Hoy T, Tighe J, Culligan D, Fegan C, Bentley P.
    Cell Cycle; 2003 Jul 15; 2(1):53-8. PubMed ID: 12695689
    [Abstract] [Full Text] [Related]

  • 13. The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells.
    Battle TE, Arbiser J, Frank DA.
    Blood; 2005 Jul 15; 106(2):690-7. PubMed ID: 15802533
    [Abstract] [Full Text] [Related]

  • 14. Flavopiridol-induced iNOS downregulation during apoptosis of chronic lymphocytic leukemia cells is caspase-dependent.
    Billard C, Menasria F, Quiney C, Faussat AM, Kolb JP.
    Leuk Res; 2008 May 15; 32(5):755-60. PubMed ID: 17981326
    [Abstract] [Full Text] [Related]

  • 15. Fludarabine-induced apoptosis of B chronic lymphocytic leukemia cells includes early cleavage of p27kip1 by caspases.
    Sanhes L, Tang R, Delmer A, DeCaprio JA, Ajchenbaum-Cymbalista F.
    Leukemia; 2003 Jun 15; 17(6):1104-11. PubMed ID: 12764376
    [Abstract] [Full Text] [Related]

  • 16. ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol.
    Mahoney E, Lucas DM, Gupta SV, Wagner AJ, Herman SE, Smith LL, Yeh YY, Andritsos L, Jones JA, Flynn JM, Blum KA, Zhang X, Lehman A, Kong H, Gurcan M, Grever MR, Johnson AJ, Byrd JC.
    Blood; 2012 Aug 09; 120(6):1262-73. PubMed ID: 22740450
    [Abstract] [Full Text] [Related]

  • 17. 2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells.
    Steele AJ, Prentice AG, Hoffbrand AV, Yogashangary BC, Hart SM, Lowdell MW, Samuel ER, North JM, Nacheva EP, Chanalaris A, Kottaridis P, Cwynarski K, Wickremasinghe RG.
    Blood; 2009 Aug 06; 114(6):1217-25. PubMed ID: 19515722
    [Abstract] [Full Text] [Related]

  • 18. Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly(ADP-ribose) polymerase cleavage.
    Nabha SM, Mohammad RM, Dandashi MH, Coupaye-Gerard B, Aboukameel A, Pettit GR, Al-Katib AM.
    Clin Cancer Res; 2002 Aug 06; 8(8):2735-41. PubMed ID: 12171907
    [Abstract] [Full Text] [Related]

  • 19. Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilization of intracellular calcium.
    Hussain SR, Lucas DM, Johnson AJ, Lin TS, Bakaletz AP, Dang VX, Viatchenko-Karpinski S, Ruppert AS, Byrd JC, Kuppusamy P, Crouser ED, Grever MR.
    Blood; 2008 Mar 15; 111(6):3190-9. PubMed ID: 18192508
    [Abstract] [Full Text] [Related]

  • 20. Noxa upregulation is associated with apoptosis of chronic lymphocytic leukemia cells induced by hyperforin but not flavopiridol.
    Zaher M, Akrout I, Mirshahi M, Kolb JP, Billard C.
    Leukemia; 2009 Mar 15; 23(3):594-6. PubMed ID: 18784742
    [No Abstract] [Full Text] [Related]

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