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156 related items for PubMed ID: 9813158

  • 1. Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPalpha secretion: control by the proteasome.
    Marambaud P, Alves da Costa C, Ancolio K, Checler F.
    Biochem Biophys Res Commun; 1998 Nov 09; 252(1):134-8. PubMed ID: 9813158
    [Abstract] [Full Text] [Related]

  • 2. C-terminal maturation fragments of presenilin 1 and 2 control secretion of APP alpha and A beta by human cells and are degraded by proteasome.
    da Costa CA, Ancolio K, Checler F.
    Mol Med; 1999 Mar 09; 5(3):160-8. PubMed ID: 10404513
    [Abstract] [Full Text] [Related]

  • 3. Proprotein convertase activity contributes to the processing of the Alzheimer's beta-amyloid precursor protein in human cells: evidence for a role of the prohormone convertase PC7 in the constitutive alpha-secretase pathway.
    Lopez-Perez E, Seidah NG, Checler F.
    J Neurochem; 1999 Nov 09; 73(5):2056-62. PubMed ID: 10537065
    [Abstract] [Full Text] [Related]

  • 4. Proteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and potentiate A beta 42 recovery from human cells.
    Marambaud P, Ancolio K, Lopez-Perez E, Checler F.
    Mol Med; 1998 Mar 09; 4(3):147-57. PubMed ID: 9562973
    [Abstract] [Full Text] [Related]

  • 5. Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation.
    Crystal AS, Morais VA, Fortna RR, Carlin D, Pierson TC, Wilson CA, Lee VM, Doms RW.
    Biochemistry; 2004 Mar 30; 43(12):3555-63. PubMed ID: 15035625
    [Abstract] [Full Text] [Related]

  • 6. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
    Wiley JC, Hudson M, Kanning KC, Schecterson LC, Bothwell M.
    J Neurochem; 2005 Sep 30; 94(5):1189-201. PubMed ID: 15992373
    [Abstract] [Full Text] [Related]

  • 7. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
    Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, Harrison T, Lellis C, Nadin A, Neduvelil JG, Register RB, Sardana MK, Shearman MS, Smith AL, Shi XP, Yin KC, Shafer JA, Gardell SJ.
    Nature; 2000 Jun 08; 405(6787):689-94. PubMed ID: 10864326
    [Abstract] [Full Text] [Related]

  • 8. The overexpression of presenilin2 and Alzheimer's-disease-linked presenilin2 variants influences TRPC6-enhanced Ca2+ entry into HEK293 cells.
    Lessard CB, Lussier MP, Cayouette S, Bourque G, Boulay G.
    Cell Signal; 2005 Apr 08; 17(4):437-45. PubMed ID: 15601622
    [Abstract] [Full Text] [Related]

  • 9. Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels.
    Zatti G, Burgo A, Giacomello M, Barbiero L, Ghidoni R, Sinigaglia G, Florean C, Bagnoli S, Binetti G, Sorbi S, Pizzo P, Fasolato C.
    Cell Calcium; 2006 Jun 08; 39(6):539-50. PubMed ID: 16620965
    [Abstract] [Full Text] [Related]

  • 10. Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells.
    Ramalho RM, Borralho PM, Castro RE, Solá S, Steer CJ, Rodrigues CM.
    J Neurochem; 2006 Sep 08; 98(5):1610-8. PubMed ID: 16923170
    [Abstract] [Full Text] [Related]

  • 11. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
    Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C.
    J Cell Biol; 2002 Aug 05; 158(3):551-61. PubMed ID: 12147673
    [Abstract] [Full Text] [Related]

  • 12. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
    Xia W, Ostaszewski BL, Kimberly WT, Rahmati T, Moore CL, Wolfe MS, Selkoe DJ.
    Neurobiol Dis; 2000 Dec 05; 7(6 Pt B):673-81. PubMed ID: 11114265
    [Abstract] [Full Text] [Related]

  • 13. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
    Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ.
    Nature; 1999 Apr 08; 398(6727):513-7. PubMed ID: 10206644
    [Abstract] [Full Text] [Related]

  • 14. Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells.
    Qi Y, Morishima-Kawashima M, Sato T, Mitsumori R, Ihara Y.
    Biochemistry; 2003 Feb 04; 42(4):1042-52. PubMed ID: 12549925
    [Abstract] [Full Text] [Related]

  • 15. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B.
    J Neurochem; 2006 Feb 04; 96(3):732-42. PubMed ID: 16405513
    [Abstract] [Full Text] [Related]

  • 16. Role of the proteasome in Alzheimer's disease.
    Checler F, da Costa CA, Ancolio K, Chevallier N, Lopez-Perez E, Marambaud P.
    Biochim Biophys Acta; 2000 Jul 26; 1502(1):133-8. PubMed ID: 10899438
    [Abstract] [Full Text] [Related]

  • 17. Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein.
    Nunan J, Williamson NA, Hill AF, Sernee MF, Masters CL, Small DH.
    J Neurosci Res; 2003 Nov 01; 74(3):378-85. PubMed ID: 14598314
    [Abstract] [Full Text] [Related]

  • 18. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
    Walker ES, Martinez M, Brunkan AL, Goate A.
    J Neurochem; 2005 Jan 01; 92(2):294-301. PubMed ID: 15663477
    [Abstract] [Full Text] [Related]

  • 19. Constitutive and protein kinase C-regulated secretory cleavage of Alzheimer's beta-amyloid precursor protein: different control of early and late events by the proteasome.
    Marambaud P, Lopez-Perez E, Wilk S, Checler F.
    J Neurochem; 1997 Dec 01; 69(6):2500-5. PubMed ID: 9375683
    [Abstract] [Full Text] [Related]

  • 20. Generation of amyloid beta protein from a presenilin-1 and betaAPP complex.
    Shizuka-Ikeda M, Matsubara E, Ikeda M, Kanai M, Tomidokoro Y, Ikeda Y, Watanabe M, Kawarabayashi T, Harigaya Y, Okamoto K, Maruyama K, Castaño EM, St George-Hyslop P, Shoji M.
    Biochem Biophys Res Commun; 2002 Mar 29; 292(2):571-8. PubMed ID: 11906199
    [Abstract] [Full Text] [Related]

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