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Journal Abstract Search

121 related items for PubMed ID: 9815193

  • 1. Thioether adducts of a new imine reactive intermediate of the pneumotoxin 3-methylindole.
    Skordos KW, Laycock JD, Yost GS.
    Chem Res Toxicol; 1998 Nov; 11(11):1326-31. PubMed ID: 9815193
    [Abstract] [Full Text] [Related]

  • 2. Evidence supporting the formation of 2,3-epoxy-3-methylindoline: a reactive intermediate of the pneumotoxin 3-methylindole.
    Skordos KW, Skiles GL, Laycock JD, Lanza DL, Yost GS.
    Chem Res Toxicol; 1998 Jul; 11(7):741-9. PubMed ID: 9671536
    [Abstract] [Full Text] [Related]

  • 3. Metabolism and bioactivation of 3-methylindole by human liver microsomes.
    Yan Z, Easterwood LM, Maher N, Torres R, Huebert N, Yost GS.
    Chem Res Toxicol; 2007 Jan; 20(1):140-8. PubMed ID: 17226936
    [Abstract] [Full Text] [Related]

  • 4. Identification of a cysteinyl adduct of oxidized 3-methylindole from goat lung and human liver microsomal proteins.
    Ruangyuttikarn W, Skiles GL, Yost GS.
    Chem Res Toxicol; 1992 Jan; 5(5):713-9. PubMed ID: 1446013
    [Abstract] [Full Text] [Related]

  • 5. Metabolism and bioactivation of 3-methylindole by Clara cells, alveolar macrophages, and subcellular fractions from rabbit lungs.
    Thornton-Manning JR, Nichols WK, Manning BW, Skiles GL, Yost GS.
    Toxicol Appl Pharmacol; 1993 Oct; 122(2):182-90. PubMed ID: 8212000
    [Abstract] [Full Text] [Related]

  • 6. Structure of the glutathione adduct of activated 3-methylindole indicates that an imine methide is the electrophilic intermediate.
    Nocerini MR, Yost GS, Carlson JR, Liberato DJ, Breeze RG.
    Drug Metab Dispos; 1985 Oct; 13(6):690-4. PubMed ID: 2867872
    [Abstract] [Full Text] [Related]

  • 7. Metabolism of 3-methylindole by vaccinia-expressed P450 enzymes: correlation of 3-methyleneindolenine formation and protein-binding.
    Thornton-Manning J, Appleton ML, Gonzalez FJ, Yost GS.
    J Pharmacol Exp Ther; 1996 Jan; 276(1):21-9. PubMed ID: 8558432
    [Abstract] [Full Text] [Related]

  • 8. Mechanistic studies on the cytochrome P450-catalyzed dehydrogenation of 3-methylindole.
    Skiles GL, Yost GS.
    Chem Res Toxicol; 1996 Jan; 9(1):291-7. PubMed ID: 8924606
    [Abstract] [Full Text] [Related]

  • 9. Identification of phase I metabolites of 3-methylindole produced by pig liver microsomes.
    Diaz GJ, Skordos KW, Yost GS, Squires EJ.
    Drug Metab Dispos; 1999 Oct; 27(10):1150-6. PubMed ID: 10497141
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  • 14. Metabolic activation of a novel 3-substituted indole-containing TNF-alpha inhibitor: dehydrogenation and inactivation of CYP3A4.
    Sun H, Yost GS.
    Chem Res Toxicol; 2008 Feb; 21(2):374-85. PubMed ID: 18095656
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  • 15. Identification of goat and mouse urinary metabolites of the pneumotoxin, 3-methylindole.
    Smith DJ, Skiles GL, Appleton ML, Carlson JR, Yost GS.
    Xenobiotica; 1993 Sep; 23(9):1025-44. PubMed ID: 8291262
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  • 16. Identification of a novel glutathione adduct of diclofenac, 4'-hydroxy-2'-glutathion-deschloro-diclofenac, upon incubation with human liver microsomes.
    Yu LJ, Chen Y, Deninno MP, O'Connell TN, Hop CE.
    Drug Metab Dispos; 2005 Apr; 33(4):484-8. PubMed ID: 15640374
    [Abstract] [Full Text] [Related]

  • 17. Identification of beta-glucuronidase-resistant diastereomeric glucuronides of 3-hydroxy-3-methyloxindole formed during 3-methylindole metabolism in goats.
    Smith DJ, Appleton ML, Carlson JR, Yost GS.
    Drug Metab Dispos; 1996 Jan; 24(1):119-25. PubMed ID: 8825199
    [Abstract] [Full Text] [Related]

  • 18. Decreased pneumotoxicity of deuterated 3-methylindole: bioactivation requires methyl C-H bond breakage.
    Huijzer JC, Adams JD, Yost GS.
    Toxicol Appl Pharmacol; 1987 Aug; 90(1):60-8. PubMed ID: 3629592
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  • 19. Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac.
    Tang W, Stearns RA, Wang RW, Chiu SH, Baillie TA.
    Chem Res Toxicol; 1999 Feb; 12(2):192-9. PubMed ID: 10027798
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  • 20. Glutathione adduct formation with microsomally activated metabolites of the pulmonary alkylating and cytotoxic agent, 3-methylindole.
    Nocerini MR, Carlson JR, Yost GS.
    Toxicol Appl Pharmacol; 1985 Oct; 81(1):75-84. PubMed ID: 4049423
    [Abstract] [Full Text] [Related]

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