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2. The high sensitivity of the rabbit to the teratogenic effects of 13-cis-retinoic acid (isotretinoin) is a consequence of prolonged exposure of the embryo to 13-cis-retinoic acid and 13-cis-4-oxo-retinoic acid, and not of isomerization to all-trans-retinoic acid. Tzimas G, Bürgin H, Collins MD, Hummler H, Nau H. Arch Toxicol; 1994 Dec; 68(2):119-28. PubMed ID: 8179481 [Abstract] [Full Text] [Related]
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8. Low teratogenicity of 13-cis-retinoic acid (isotretinoin) in the mouse corresponds to low embryo concentrations during organogenesis: comparison to the all-trans isomer. Kraft JC, Kochhar DM, Scott WJ, Nau H. Toxicol Appl Pharmacol; 1987 Mar 15; 87(3):474-82. PubMed ID: 3470977 [Abstract] [Full Text] [Related]
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