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202 related items for PubMed ID: 9850074

  • 1. Expression, characterization, and detection of human uridine phosphorylase and identification of variant uridine phosphorolytic activity in selected human tumors.
    Liu M, Cao D, Russell R, Handschumacher RE, Pizzorno G.
    Cancer Res; 1998 Dec 01; 58(23):5418-24. PubMed ID: 9850074
    [Abstract] [Full Text] [Related]

  • 2. Phase I clinical and pharmacological studies of benzylacyclouridine, a uridine phosphorylase inhibitor.
    Pizzorno G, Yee L, Burtness BA, Marsh JC, Darnowski JW, Chu MY, Chu SH, Chu E, Leffert JJ, Handschumacher RE, Calabresi P.
    Clin Cancer Res; 1998 May 01; 4(5):1165-75. PubMed ID: 9607574
    [Abstract] [Full Text] [Related]

  • 3. Identification of a novel human uridine phosphorylase.
    Johansson M.
    Biochem Biophys Res Commun; 2003 Jul 18; 307(1):41-6. PubMed ID: 12849978
    [Abstract] [Full Text] [Related]

  • 4. Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines.
    Temmink OH, de Bruin M, Turksma AW, Cricca S, Laan AC, Peters GJ.
    Int J Biochem Cell Biol; 2007 Jul 18; 39(3):565-75. PubMed ID: 17098463
    [Abstract] [Full Text] [Related]

  • 5. Tissue-specific enhancement of uridine utilization and 5-fluorouracil therapy in mice by benzylacyclouridine.
    Darnowski JW, Handschumacher RE.
    Cancer Res; 1985 Nov 18; 45(11 Pt 1):5364-8. PubMed ID: 4053009
    [Abstract] [Full Text] [Related]

  • 6. Inhibition of nucleoside transport in murine lymphoma L5178Y cells and human erythrocytes by the uridine phosphorylase inhibitors 5-benzylacyclouridine and 5-benzyloxybenzylacyclouridine.
    Lee KH, el Kouni MH, Chu HS, Cha S.
    Cancer Res; 1984 Sep 18; 44(9):3744-8. PubMed ID: 6744292
    [Abstract] [Full Text] [Related]

  • 7. Uridine phosphorylase (-/-) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines.
    Cao D, Russell RL, Zhang D, Leffert JJ, Pizzorno G.
    Cancer Res; 2002 Apr 15; 62(8):2313-7. PubMed ID: 11956089
    [Abstract] [Full Text] [Related]

  • 8. Effect of 5-benzylacyclouridine, a potent inhibitor of uridine phosphorylase, on the metabolism of circulating uridine by the isolated rat liver.
    Monks A, Ayers O, Cysyk RL.
    Biochem Pharmacol; 1983 Jul 01; 32(13):2003-9. PubMed ID: 6870929
    [Abstract] [Full Text] [Related]

  • 9. Tissue-specific expansion of uridine pools in mice. Effects of benzylacyclouridine, dipyridamole and exogenous uridine.
    Darnowski JW, Handschumacher RE, Wiegand RA, Goulette FA, Calabresi P.
    Biochem Pharmacol; 1991 Jun 15; 41(12):2031-6. PubMed ID: 2039551
    [Abstract] [Full Text] [Related]

  • 10. Uridine phosophorylase: an important enzyme in pyrimidine metabolism and fluoropyrimidine activation.
    Cao D, Pizzorno G.
    Drugs Today (Barc); 2004 May 15; 40(5):431-43. PubMed ID: 15319798
    [Abstract] [Full Text] [Related]

  • 11. Effects of 5-benzylacyclouridine, an inhibitor of uridine phosphorylase, on the pharmacokinetics of uridine in rhesus monkeys: implications for chemotherapy.
    Sommadossi JP, Cretton EM, Kidd LB, McClure HM, Anderson DC, el Kouni MH.
    Cancer Chemother Pharmacol; 1995 May 15; 37(1-2):14-22. PubMed ID: 7497584
    [Abstract] [Full Text] [Related]

  • 12. 19F NMR monitoring of in vivo tumor metabolism after biochemical modulation of 5-fluorouracil by the uridine phosphorylase inhibitor 5-benzylacyclouridine.
    Holland SK, Bergman AM, Zhao Y, Adams ER, Pizzorno G.
    Magn Reson Med; 1997 Dec 15; 38(6):907-16. PubMed ID: 9402191
    [Abstract] [Full Text] [Related]

  • 13. Purification, cloning, and expression of murine uridine phosphorylase.
    Watanabe S, Hino A, Wada K, Eliason JF, Uchida T.
    J Biol Chem; 1995 May 19; 270(20):12191-6. PubMed ID: 7744869
    [Abstract] [Full Text] [Related]

  • 14. Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy.
    Roosild TP, Castronovo S, Fabbiani M, Pizzorno G.
    BMC Struct Biol; 2009 Mar 16; 9():14. PubMed ID: 19291308
    [Abstract] [Full Text] [Related]

  • 15. [Purification and characterization of a uridine phosphorylase from Enterobacter aerogenes EAM-Z1].
    Ruan Q, Zhou C, Xu X, Wu W.
    Wei Sheng Wu Xue Bao; 2003 Jun 16; 43(3):354-60. PubMed ID: 16279202
    [Abstract] [Full Text] [Related]

  • 16. Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma.
    Miyashita H, Takebayashi Y, Eliason JF, Fujimori F, Nitta Y, Sato A, Morikawa H, Ohashi A, Motegi K, Fukumoto M, Mori S, Uchida T.
    Cancer; 2002 Jun 01; 94(11):2959-66. PubMed ID: 12115385
    [Abstract] [Full Text] [Related]

  • 17. Use of oral uridine as a substitute for parenteral uridine rescue of 5-fluorouracil therapy, with and without the uridine phosphorylase inhibitor 5-benzylacyclouridine.
    Martin DS, Stolfi RL, Sawyer RC.
    Cancer Chemother Pharmacol; 1989 Jun 01; 24(1):9-14. PubMed ID: 2720896
    [Abstract] [Full Text] [Related]

  • 18. Isolation and initial characterization of the uridine phosphorylase from Salmonella typhimurium.
    Molchan OK, Dmitrieva NA, Romanova DV, Lopes LE, Debabov VG, Mironov AS.
    Biochemistry (Mosc); 1998 Feb 01; 63(2):195-9. PubMed ID: 9526114
    [Abstract] [Full Text] [Related]

  • 19. Uridine phosphorylase from Novikoff rat hepatoma cells: purification, kinetic properties, and its role in uracil anabolism.
    McIvor RS, Wohlhueter RM, Plagemann PP.
    J Cell Physiol; 1985 Mar 01; 122(3):397-404. PubMed ID: 2981897
    [Abstract] [Full Text] [Related]

  • 20. Role of uridine phosphorylase in the anabolism of 5-fluorouracil.
    Schwartz PM, Moir RD, Hyde CM, Turek PJ, Handschumacher RE.
    Biochem Pharmacol; 1985 Oct 01; 34(19):3585-9. PubMed ID: 2996553
    [Abstract] [Full Text] [Related]


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