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567 related items for PubMed ID: 9857098

  • 1. Synthesis and potent antifolate activity and cytotoxicity of B-ring deaza analogues of the nonpolyglutamatable dihydrofolate reductase inhibitor Nalpha-(4-amino-4-deoxypteroyl)-Ndelta-hemiphthaloyl- L-ornithine (PT523).
    Rosowsky A, Wright JE, Vaidya CM, Bader H, Forsch RA, Mota CE, Pardo J, Chen CS, Chen YN.
    J Med Chem; 1998 Dec 17; 41(26):5310-9. PubMed ID: 9857098
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  • 3. Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells.
    Chen G, Wright JE, Rosowsky A.
    Mol Pharmacol; 1995 Oct 17; 48(4):758-65. PubMed ID: 7476904
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  • 5. Analogues of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (PT523) with modifications in the side chain, p-aminobenzoyl moiety, or 9,10-bridge: synthesis and in vitro antitumor activity.
    Rosowsky A, Wright JE, Vaidya CM, Forsch RA, Bader H.
    J Med Chem; 2000 Apr 20; 43(8):1620-34. PubMed ID: 10780919
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  • 7. Synthesis and biological activity of N omega-hemiphthaloyl-alpha,omega- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin.
    Rosowsky A, Bader H, Wright JE, Keyomarsi K, Matherly LH.
    J Med Chem; 1994 Jul 08; 37(14):2167-74. PubMed ID: 8035423
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  • 9. Synthesis and in vitro biological activity of new deaza analogues of folic acid, aminopterin, and methotrexate with an L-ornithine side chain.
    Rosowsky A, Forsch RA, Bader H, Freisheim JH.
    J Med Chem; 1991 Apr 08; 34(4):1447-54. PubMed ID: 2016722
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  • 11. The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine.
    Rosowsky A, Wright JE, Vaidya CM, Forsch RA.
    Pharmacol Ther; 2000 Mar 08; 85(3):191-205. PubMed ID: 10739874
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  • 12. PT523 and other aminopterin analogs with a hemiphthaloyl-L-ornithine side chain: exceptionally tight-binding inhibitors of dihydrofolate reductase which are transported by the reduced folate carrier but cannot form polyglutamates.
    Rosowsky A.
    Curr Med Chem; 1999 Apr 08; 6(4):329-52. PubMed ID: 10101216
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  • 13. NMR solution structure of the antitumor compound PT523 and NADPH in the ternary complex with human dihydrofolate reductase.
    Johnson JM, Meiering EM, Wright JE, Pardo J, Rosowsky A, Wagner G.
    Biochemistry; 1997 Apr 15; 36(15):4399-411. PubMed ID: 9109647
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  • 14. 2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases.
    Gangjee A, Vasudevan A, Queener SF, Kisliuk RL.
    J Med Chem; 1996 Mar 29; 39(7):1438-46. PubMed ID: 8691474
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  • 15. Novel 8-deaza-5,6,7,8-tetrahydroaminopterin derivatives as dihydrofolate inhibitor: design, synthesis and antifolate activity.
    Zhang Z, Wu J, Ran F, Guo Y, Tian R, Zhou S, Wang X, Liu Z, Zhang L, Cui J, Liu J.
    Eur J Med Chem; 2009 Feb 29; 44(2):764-71. PubMed ID: 18555562
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  • 16. Synthesis and in vitro antifolate activity of rotationally restricted aminopterin and methotrexate analogues.
    Rosowsky A, Forsch RA, Wright JE.
    J Med Chem; 2004 Dec 30; 47(27):6958-63. PubMed ID: 15615544
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  • 17. Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523.
    Cody V, Galitsky N, Luft JR, Pangborn W, Rosowsky A, Blakley RL.
    Biochemistry; 1997 Nov 11; 36(45):13897-903. PubMed ID: 9374868
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  • 20. Novel 6,5-fused ring heterocyclic antifolates: biochemical and biological characterization.
    McGuire JJ, Bergoltz VV, Heitzman KJ, Haile WH, Russell CA, Bolanowska WE, Kotake Y, Haneda T, Nomura H.
    Cancer Res; 1994 May 15; 54(10):2673-9. PubMed ID: 8168096
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