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Journal Abstract Search

492 related items for PubMed ID: 9865924

  • 1. A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent.
    Winski SL, Hargreaves RH, Butler J, Ross D.
    Clin Cancer Res; 1998 Dec; 4(12):3083-8. PubMed ID: 9865924
    [Abstract] [Full Text] [Related]

  • 2. Nicotinamide adenine dinucleotide (phosphate): quinone oxidoreductase (DT-diaphorase) as a target for bioreductive antitumor quinones: quinone cytotoxicity and selectivity in human lung and breast cancer cell lines.
    Beall HD, Murphy AM, Siegel D, Hargreaves RH, Butler J, Ross D.
    Mol Pharmacol; 1995 Sep; 48(3):499-504. PubMed ID: 7565631
    [Abstract] [Full Text] [Related]

  • 3. Effect of NQO1 induction on the antitumor activity of RH1 in human tumors in vitro and in vivo.
    Digby T, Leith MK, Thliveris JA, Begleiter A.
    Cancer Chemother Pharmacol; 2005 Sep; 56(3):307-16. PubMed ID: 15877230
    [Abstract] [Full Text] [Related]

  • 4. Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones.
    Winski SL, Swann E, Hargreaves RH, Dehn DL, Butler J, Moody CJ, Ross D.
    Biochem Pharmacol; 2001 Jun 15; 61(12):1509-16. PubMed ID: 11377380
    [Abstract] [Full Text] [Related]

  • 5. Development of a new isogenic cell-xenograft system for evaluation of NAD(P)H:quinone oxidoreductase-directed antitumor quinones: evaluation of the activity of RH1.
    Dehn DL, Winski SL, Ross D.
    Clin Cancer Res; 2004 May 01; 10(9):3147-55. PubMed ID: 15131056
    [Abstract] [Full Text] [Related]

  • 6. Role of NAD(P)H:quinone oxidoreductase (NQO1) in apoptosis induction by aziridinylbenzoquinones RH1 and MeDZQ.
    Nemeikaite-Ceniene A, Dringeliene A, Sarlauskas J, Cenas N.
    Acta Biochim Pol; 2005 May 01; 52(4):937-41. PubMed ID: 15940348
    [Abstract] [Full Text] [Related]

  • 7. The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase.
    Fourie J, Oleschuk CJ, Guziec F, Guziec L, Fiterman DJ, Monterrosa C, Begleiter A.
    Cancer Chemother Pharmacol; 2002 Feb 01; 49(2):101-10. PubMed ID: 11862423
    [Abstract] [Full Text] [Related]

  • 8. Activity profile of the novel aziridinylbenzoquinones MeDZQ and RH1 in human tumour xenografts.
    Cummings J, Ritchie A, Butler J, Ward TH, Langdon S.
    Anticancer Res; 2003 Feb 01; 23(5A):3979-83. PubMed ID: 14666706
    [Abstract] [Full Text] [Related]

  • 9. Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies.
    Ross D, Beall H, Traver RD, Siegel D, Phillips RM, Gibson NW.
    Oncol Res; 1994 Feb 01; 6(10-11):493-500. PubMed ID: 7620217
    [Abstract] [Full Text] [Related]

  • 10. Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: a novel co-substrate-mediated antitumor prodrug therapy.
    Knox RJ, Jenkins TC, Hobbs SM, Chen S, Melton RG, Burke PJ.
    Cancer Res; 2000 Aug 01; 60(15):4179-86. PubMed ID: 10945627
    [Abstract] [Full Text] [Related]

  • 11. The reductive activation of the antitumor drug RH1 to its semiquinone free radical by NADPH cytochrome P450 reductase and by HCT116 human colon cancer cells.
    Hasinoff BB, Begleiter A.
    Free Radic Res; 2006 Sep 01; 40(9):974-8. PubMed ID: 17015278
    [Abstract] [Full Text] [Related]

  • 12. Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1).
    Yan C, Kepa JK, Siegel D, Stratford IJ, Ross D.
    Mol Pharmacol; 2008 Dec 01; 74(6):1657-65. PubMed ID: 18794327
    [Abstract] [Full Text] [Related]

  • 13. Role of NADPH cytochrome P450 reductase in activation of RH1.
    Begleiter A, Leith MK, Patel D, Hasinoff BB.
    Cancer Chemother Pharmacol; 2007 Oct 01; 60(5):713-23. PubMed ID: 17256129
    [Abstract] [Full Text] [Related]

  • 14. Relationship between DT-diaphorase-mediated metabolism of a series of aziridinylbenzoquinones and DNA damage and cytotoxicity.
    Gibson NW, Hartley JA, Butler J, Siegel D, Ross D.
    Mol Pharmacol; 1992 Sep 01; 42(3):531-6. PubMed ID: 1406604
    [Abstract] [Full Text] [Related]

  • 15. The role of NAD(P)H:quinone oxidoreductase in quinone-mediated p21 induction in human colon carcinoma cells.
    Qiu XB, Cadenas E.
    Arch Biochem Biophys; 1997 Oct 15; 346(2):241-51. PubMed ID: 9343371
    [Abstract] [Full Text] [Related]

  • 16. NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity.
    Traver RD, Horikoshi T, Danenberg KD, Stadlbauer TH, Danenberg PV, Ross D, Gibson NW.
    Cancer Res; 1992 Feb 15; 52(4):797-802. PubMed ID: 1737339
    [Abstract] [Full Text] [Related]

  • 17. Indolequinone antitumor agents: correlation between quinone structure, rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase, and in vitro cytotoxicity.
    Beall HD, Winski S, Swann E, Hudnott AR, Cotterill AS, O'Sullivan N, Green SJ, Bien R, Siegel D, Ross D, Moody CJ.
    J Med Chem; 1998 Nov 19; 41(24):4755-66. PubMed ID: 9822546
    [Abstract] [Full Text] [Related]

  • 18. Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1).
    Fryatt T, Pettersson HI, Gardipee WT, Bray KC, Green SJ, Slawin AM, Beall HD, Moody CJ.
    Bioorg Med Chem; 2004 Apr 01; 12(7):1667-87. PubMed ID: 15028260
    [Abstract] [Full Text] [Related]

  • 19. Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin Cł.
    Malkinson AM, Siegel D, Forrest GL, Gazdar AF, Oie HK, Chan DC, Bunn PA, Mabry M, Dykes DJ, Harrison SD.
    Cancer Res; 1992 Sep 01; 52(17):4752-7. PubMed ID: 1324793
    [Abstract] [Full Text] [Related]

  • 20. Immunohistochemical detection of NAD(P)H:quinone oxidoreductase in human lung and lung tumors.
    Siegel D, Franklin WA, Ross D.
    Clin Cancer Res; 1998 Sep 01; 4(9):2065-70. PubMed ID: 9748120
    [Abstract] [Full Text] [Related]

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