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211 related items for PubMed ID: 9882287

  • 1. Addition of a missense mutation present in the L gene of respiratory syncytial virus (RSV) cpts530/1030 to RSV vaccine candidate cpts248/404 increases its attenuation and temperature sensitivity.
    Whitehead SS, Firestone CY, Karron RA, Crowe JE, Elkins WR, Collins PL, Murphy BR.
    J Virol; 1999 Feb; 73(2):871-7. PubMed ID: 9882287
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  • 4. The temperature-sensitive (ts) phenotype of a cold-passaged (cp) live attenuated respiratory syncytial virus vaccine candidate, designated cpts530, results from a single amino acid substitution in the L protein.
    Juhasz K, Whitehead SS, Bui PT, Biggs JM, Crowe JE, Boulanger CA, Collins PL, Murphy BR.
    J Virol; 1997 Aug; 71(8):5814-9. PubMed ID: 9223470
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  • 5. Replacement of the F and G proteins of respiratory syncytial virus (RSV) subgroup A with those of subgroup B generates chimeric live attenuated RSV subgroup B vaccine candidates.
    Whitehead SS, Hill MG, Firestone CY, St Claire M, Elkins WR, Murphy BR, Collins PL.
    J Virol; 1999 Dec; 73(12):9773-80. PubMed ID: 10559287
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  • 6. Attenuation of the recombinant human parainfluenza virus type 3 cp45 candidate vaccine virus is augmented by importation of the respiratory syncytial virus cpts530 L polymerase mutation.
    Skiadopoulos MH, Surman SR, St Claire M, Elkins WR, Collins PL, Murphy BR.
    Virology; 1999 Jul 20; 260(1):125-35. PubMed ID: 10405364
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  • 7. Evaluation of two live, cold-passaged, temperature-sensitive respiratory syncytial virus vaccines in chimpanzees and in human adults, infants, and children.
    Karron RA, Wright PF, Crowe JE, Clements-Mann ML, Thompson J, Makhene M, Casey R, Murphy BR.
    J Infect Dis; 1997 Dec 20; 176(6):1428-36. PubMed ID: 9395351
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  • 8. Isolation and characterization of a highly attenuated respiratory syncytial virus (RSV) vaccine candidate by mutagenesis of the incompletely attenuated RSV A2 ts-1 NG-1 mutant virus.
    Hsu KH, Crowe JE, Lubeck MD, Davis AR, Hung PP, Chanock RM, Murphy BR.
    Vaccine; 1995 Apr 20; 13(5):509-15. PubMed ID: 7543716
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  • 9. Satisfactorily attenuated and protective mutants derived from a partially attenuated cold-passaged respiratory syncytial virus mutant by introduction of additional attenuating mutations during chemical mutagenesis.
    Crowe JE, Bui PT, London WT, Davis AR, Hung PP, Chanock RM, Murphy BR.
    Vaccine; 1994 Jun 20; 12(8):691-9. PubMed ID: 8091846
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  • 10. Respiratory syncytial virus modified by deletions of the NS2 gene and amino acid S1313 of the L polymerase protein is a temperature-sensitive, live-attenuated vaccine candidate that is phenotypically stable at physiological temperature.
    Luongo C, Winter CC, Collins PL, Buchholz UJ.
    J Virol; 2013 Feb 20; 87(4):1985-96. PubMed ID: 23236065
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  • 11. Increased genetic and phenotypic stability of a promising live-attenuated respiratory syncytial virus vaccine candidate by reverse genetics.
    Luongo C, Winter CC, Collins PL, Buchholz UJ.
    J Virol; 2012 Oct 20; 86(19):10792-804. PubMed ID: 22837193
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  • 12. Respiratory syncytial virus (RSV) SH and G proteins are not essential for viral replication in vitro: clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant.
    Karron RA, Buonagurio DA, Georgiu AF, Whitehead SS, Adamus JE, Clements-Mann ML, Harris DO, Randolph VB, Udem SA, Murphy BR, Sidhu MS.
    Proc Natl Acad Sci U S A; 1997 Dec 09; 94(25):13961-6. PubMed ID: 9391135
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  • 16. Stable Attenuation of Human Respiratory Syncytial Virus for Live Vaccines by Deletion and Insertion of Amino Acids in the Hinge Region between the mRNA Capping and Methyltransferase Domains of the Large Polymerase Protein.
    Xue M, Wang R, Harder O, Chen P, Lu M, Cai H, Li A, Liang X, Jennings R, La Perle K, Niewiesk S, Peeples ME, Li J.
    J Virol; 2020 Nov 23; 94(24):. PubMed ID: 32999025
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  • 19. Sequential addition of temperature-sensitive missense mutations into the PB2 gene of influenza A transfectant viruses can effect an increase in temperature sensitivity and attenuation and permits the rational design of a genetically engineered live influenza A virus vaccine.
    Subbarao EK, Park EJ, Lawson CM, Chen AY, Murphy BR.
    J Virol; 1995 Oct 23; 69(10):5969-77. PubMed ID: 7666501
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  • 20. Codon stabilization analysis of the "248" temperature sensitive mutation for increased phenotypic stability of respiratory syncytial virus vaccine candidates.
    Luongo C, Yang L, Winter CC, Spann KM, Murphy BR, Collins PL, Buchholz UJ.
    Vaccine; 2009 Sep 18; 27(41):5667-76. PubMed ID: 19646406
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