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230 related items for PubMed ID: 9883847

  • 1. Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.
    Guo Q, Fu W, Sopher BL, Miller MW, Ware CB, Martin GM, Mattson MP.
    Nat Med; 1999 Jan; 5(1):101-6. PubMed ID: 9883847
    [Abstract] [Full Text] [Related]

  • 2. Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease.
    Mohmmad Abdul H, Sultana R, Keller JN, St Clair DK, Markesbery WR, Butterfield DA.
    J Neurochem; 2006 Mar; 96(5):1322-35. PubMed ID: 16478525
    [Abstract] [Full Text] [Related]

  • 3. Presenilin-1 deficiency impairs glutamate-evoked intracellular calcium responses in neurons.
    Yang Y, Cook DG.
    Neuroscience; 2004 Mar; 124(3):501-5. PubMed ID: 14980721
    [Abstract] [Full Text] [Related]

  • 4. Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.
    Terro F, Czech C, Esclaire F, Elyaman W, Yardin C, Baclet MC, Touchet N, Tremp G, Pradier L, Hugon J.
    J Neurosci Res; 2002 Aug 15; 69(4):530-9. PubMed ID: 12210846
    [Abstract] [Full Text] [Related]

  • 5. Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice.
    Eckert A, Schindowski K, Leutner S, Luckhaus C, Touchet N, Czech C, Müller WE.
    Neurobiol Dis; 2001 Apr 15; 8(2):331-42. PubMed ID: 11300728
    [Abstract] [Full Text] [Related]

  • 6. Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation.
    Guo Q, Sebastian L, Sopher BL, Miller MW, Glazner GW, Ware CB, Martin GM, Mattson MP.
    Proc Natl Acad Sci U S A; 1999 Mar 30; 96(7):4125-30. PubMed ID: 10097174
    [Abstract] [Full Text] [Related]

  • 7. Presenilin-1-deficient neurons are nitric oxide-dependently killed by hydrogen peroxide in vitro.
    Nakajima M, Shirasawa T.
    Neuroscience; 2004 Mar 30; 125(3):563-8. PubMed ID: 15099670
    [Abstract] [Full Text] [Related]

  • 8. Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation.
    Zhu H, Guo Q, Mattson MP.
    Brain Res; 1999 Sep 18; 842(1):224-9. PubMed ID: 10526115
    [Abstract] [Full Text] [Related]

  • 9. Functional phenotype in transgenic mice expressing mutant human presenilin-1.
    Barrow PA, Empson RM, Gladwell SJ, Anderson CM, Killick R, Yu X, Jefferys JG, Duff K.
    Neurobiol Dis; 2000 Apr 18; 7(2):119-26. PubMed ID: 10783295
    [Abstract] [Full Text] [Related]

  • 10. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice.
    Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA.
    Exp Neurol; 2004 Aug 18; 188(2):224-37. PubMed ID: 15246822
    [Abstract] [Full Text] [Related]

  • 11. Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis.
    Mattson MP, Zhu H, Yu J, Kindy MS.
    J Neurosci; 2000 Feb 15; 20(4):1358-64. PubMed ID: 10662826
    [Abstract] [Full Text] [Related]

  • 12. Abnormal intracellular trafficking of high affinity nerve growth factor receptor, Trk, in stable transfectants expressing presenilin 1 protein.
    Hamano T, Mutoh T, Tabira T, Araki W, Kuriyama M, Mihara T, Yano S, Yamamoto H.
    Brain Res Mol Brain Res; 2005 Jun 13; 137(1-2):70-6. PubMed ID: 15950763
    [Abstract] [Full Text] [Related]

  • 13. Reelin-immunoreactivity in the hippocampal formation of 9-month-old wildtype mouse: effects of APP/PS1 genotype and ovariectomy.
    Miettinen R, Riedel A, Kalesnykas G, Kettunen HP, Puoliväli J, Soininen H, Arendt T.
    J Chem Neuroanat; 2005 Oct 13; 30(2-3):105-18. PubMed ID: 16081247
    [Abstract] [Full Text] [Related]

  • 14. ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis.
    Kruman II, Pedersen WA, Springer JE, Mattson MP.
    Exp Neurol; 1999 Nov 13; 160(1):28-39. PubMed ID: 10630188
    [Abstract] [Full Text] [Related]

  • 15. Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.
    Guo Q, Sebastian L, Sopher BL, Miller MW, Ware CB, Martin GM, Mattson MP.
    J Neurochem; 1999 Mar 13; 72(3):1019-29. PubMed ID: 10037473
    [Abstract] [Full Text] [Related]

  • 16. Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12.
    Chan SL, Culmsee C, Haughey N, Klapper W, Mattson MP.
    Neurobiol Dis; 2002 Oct 13; 11(1):2-19. PubMed ID: 12460542
    [Abstract] [Full Text] [Related]

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  • 19. Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1.
    Parent A, Linden DJ, Sisodia SS, Borchelt DR.
    Neurobiol Dis; 1999 Feb 13; 6(1):56-62. PubMed ID: 10078973
    [Abstract] [Full Text] [Related]

  • 20. Enhanced caffeine-induced Ca2+ release in the 3xTg-AD mouse model of Alzheimer's disease.
    Smith IF, Hitt B, Green KN, Oddo S, LaFerla FM.
    J Neurochem; 2005 Sep 13; 94(6):1711-8. PubMed ID: 16156741
    [Abstract] [Full Text] [Related]

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