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Journal Abstract Search

285 related items for PubMed ID: 9887328

  • 1. In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease.
    Hackam AS, Singaraja R, Zhang T, Gan L, Hayden MR.
    Hum Mol Genet; 1999 Jan; 8(1):25-33. PubMed ID: 9887328
    [Abstract] [Full Text] [Related]

  • 2. Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease in cell culture and in transgenic mice expressing mutant huntingtin.
    Hackam AS, Hodgson JG, Singaraja R, Zhang T, Gan L, Gutekunst CA, Hersch SM, Hayden MR.
    Philos Trans R Soc Lond B Biol Sci; 1999 Jun 29; 354(1386):1047-55. PubMed ID: 10434304
    [Abstract] [Full Text] [Related]

  • 3. A cellular model that recapitulates major pathogenic steps of Huntington's disease.
    Lunkes A, Mandel JL.
    Hum Mol Genet; 1998 Sep 29; 7(9):1355-61. PubMed ID: 9700187
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  • 4. Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture.
    Cooper JK, Schilling G, Peters MF, Herring WJ, Sharp AH, Kaminsky Z, Masone J, Khan FA, Delanoy M, Borchelt DR, Dawson VL, Dawson TM, Ross CA.
    Hum Mol Genet; 1998 May 29; 7(5):783-90. PubMed ID: 9536081
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  • 5. Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions.
    Lunkes A, Lindenberg KS, Ben-Haïem L, Weber C, Devys D, Landwehrmeyer GB, Mandel JL, Trottier Y.
    Mol Cell; 2002 Aug 29; 10(2):259-69. PubMed ID: 12191472
    [Abstract] [Full Text] [Related]

  • 6. Rapid aggregate formation of the huntingtin N-terminal fragment carrying an expanded polyglutamine tract.
    Hazeki N, Nakamura K, Goto J, Kanazawa I.
    Biochem Biophys Res Commun; 1999 Mar 16; 256(2):361-6. PubMed ID: 10079189
    [Abstract] [Full Text] [Related]

  • 7. Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins.
    Huang CC, Faber PW, Persichetti F, Mittal V, Vonsattel JP, MacDonald ME, Gusella JF.
    Somat Cell Mol Genet; 1998 Jul 16; 24(4):217-33. PubMed ID: 10410676
    [Abstract] [Full Text] [Related]

  • 8. Huntingtin contains a highly conserved nuclear export signal.
    Xia J, Lee DH, Taylor J, Vandelft M, Truant R.
    Hum Mol Genet; 2003 Jun 15; 12(12):1393-403. PubMed ID: 12783847
    [Abstract] [Full Text] [Related]

  • 9. Polyglutamine pathogenesis.
    Ross CA, Wood JD, Schilling G, Peters MF, Nucifora FC, Cooper JK, Sharp AH, Margolis RL, Borchelt DR.
    Philos Trans R Soc Lond B Biol Sci; 1999 Jun 29; 354(1386):1005-11. PubMed ID: 10434299
    [Abstract] [Full Text] [Related]

  • 10. Aggregation of N-terminal huntingtin is dependent on the length of its glutamine repeats.
    Li SH, Li XJ.
    Hum Mol Genet; 1998 May 29; 7(5):777-82. PubMed ID: 9536080
    [Abstract] [Full Text] [Related]

  • 11. Huntingtin fragments that aggregate go their separate ways.
    DiFiglia M.
    Mol Cell; 2002 Aug 29; 10(2):224-5. PubMed ID: 12191468
    [Abstract] [Full Text] [Related]

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  • 14. Protein aggregation in Huntington's disease.
    Hoffner G, Djian P.
    Biochimie; 2002 Apr 29; 84(4):273-8. PubMed ID: 12106904
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  • 16. Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice.
    Schilling G, Savonenko AV, Klevytska A, Morton JL, Tucker SM, Poirier M, Gale A, Chan N, Gonzales V, Slunt HH, Coonfield ML, Jenkins NA, Copeland NG, Ross CA, Borchelt DR.
    Hum Mol Genet; 2004 Aug 01; 13(15):1599-610. PubMed ID: 15190011
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  • 18. Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release.
    Jana NR, Zemskov EA, Wang Gh, Nukina N.
    Hum Mol Genet; 2001 May 01; 10(10):1049-59. PubMed ID: 11331615
    [Abstract] [Full Text] [Related]

  • 19. Are there multiple pathways in the pathogenesis of Huntington's disease?
    Aronin N, Kim M, Laforet G, DiFiglia M.
    Philos Trans R Soc Lond B Biol Sci; 1999 Jun 29; 354(1386):995-1003. PubMed ID: 10434298
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