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381 related items for PubMed ID: 9893962

  • 1. Antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1: in vitro and in vivo studies with prodrugs of methotrexate and the thymidylate synthase inhibitors GW1031 and GW1843.
    Wolfe LA, Mullin RJ, Laethem R, Blumenkopf TA, Cory M, Miller JF, Keith BR, Humphreys J, Smith GK.
    Bioconjug Chem; 1999; 10(1):38-48. PubMed ID: 9893962
    [Abstract] [Full Text] [Related]

  • 2. Toward antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1 and novel in vivo stable prodrugs of methotrexate.
    Smith GK, Banks S, Blumenkopf TA, Cory M, Humphreys J, Laethem RM, Miller J, Moxham CP, Mullin R, Ray PH, Walton LM, Wolfe LA.
    J Biol Chem; 1997 Jun 20; 272(25):15804-16. PubMed ID: 9188478
    [Abstract] [Full Text] [Related]

  • 3. Prodrugs of thymidylate synthase inhibitors: potential for antibody directed enzyme prodrug therapy (ADEPT).
    Springer CJ, Bavetsias V, Jackman AL, Boyle FT, Marshall D, Pedley RB, Bisset GM.
    Anticancer Drug Des; 1996 Dec 20; 11(8):625-36. PubMed ID: 9022750
    [Abstract] [Full Text] [Related]

  • 4. Antitumor activity of antifolate inhibitors of thymidylate and purine synthesis in human soft tissue sarcoma cell lines with intrinsic resistance to methotrexate.
    Li WW, Tong WP, Bertino JR.
    Clin Cancer Res; 1995 Jun 20; 1(6):631-6. PubMed ID: 9816025
    [Abstract] [Full Text] [Related]

  • 5. Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2.
    Laethem RM, Blumenkopf TA, Cory M, Elwell L, Moxham CP, Ray PH, Walton LM, Smith GK.
    Arch Biochem Biophys; 1996 Aug 01; 332(1):8-18. PubMed ID: 8806703
    [Abstract] [Full Text] [Related]

  • 6. Specific tumour localisation of a huA33 antibody--carboxypeptidase A conjugate and activation of methotrexate-phenylalanine.
    Deckert PM, Bornmann WG, Ritter G, Williams C, Franke J, Keilholz U, Thiel E, Old LJ, Bertino JR, Welt S.
    Int J Oncol; 2004 May 01; 24(5):1289-95. PubMed ID: 15067353
    [Abstract] [Full Text] [Related]

  • 7. In vitro and in vivo prodrug therapy of prostate cancer using anti-gamma-Sm-scFv/hCPA fusion protein.
    Hao XK, Liu JY, Yue QH, Wu GJ, Bai YJ, Yin Y.
    Prostate; 2006 Jun 01; 66(8):858-66. PubMed ID: 16491483
    [Abstract] [Full Text] [Related]

  • 8. Methotrexate-alpha-phenylalanine: optimization of methotrexate prodrug for activation by carboxypeptidase A-monoclonal antibody conjugate.
    Vitols KS, Haag-Zeino B, Baer T, Montejano YD, Huennekens FM.
    Cancer Res; 1995 Feb 01; 55(3):478-81. PubMed ID: 7834611
    [Abstract] [Full Text] [Related]

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  • 10. Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions.
    Peters GJ, Smitskamp-Wilms E, Smid K, Pinedo HM, Jansen G.
    Cancer Res; 1999 Nov 01; 59(21):5529-35. PubMed ID: 10554030
    [Abstract] [Full Text] [Related]

  • 11. Novel inhibitors of carboxypeptidase G2 (CPG2): potential use in antibody-directed enzyme prodrug therapy.
    Khan TH, Eno-Amooquaye EA, Searle F, Browne PJ, Osborn HM, Burke PJ.
    J Med Chem; 1999 Mar 25; 42(6):951-6. PubMed ID: 10090777
    [Abstract] [Full Text] [Related]

  • 12. BGC 945, a novel tumor-selective thymidylate synthase inhibitor targeted to alpha-folate receptor-overexpressing tumors.
    Gibbs DD, Theti DS, Wood N, Green M, Raynaud F, Valenti M, Forster MD, Mitchell F, Bavetsias V, Henderson E, Jackman AL.
    Cancer Res; 2005 Dec 15; 65(24):11721-8. PubMed ID: 16357184
    [Abstract] [Full Text] [Related]

  • 13. Effects and interaction of 7-hydroxy methotrexate and methotrexate in leukaemic cells ex vivo measured by the thymidylate synthase inhibition assay.
    Lingg RM, Hempel G, Rots MG, Van Zantwijk CH, Boos J, Kaspers GJ.
    Cancer Chemother Pharmacol; 2005 Sep 15; 56(3):322-7. PubMed ID: 15868145
    [Abstract] [Full Text] [Related]

  • 14. Enhancement of antibody-directed enzyme prodrug therapy in colorectal xenografts by an antivascular agent.
    Pedley RB, Sharma SK, Boxer GM, Boden R, Stribbling SM, Davies L, Springer CJ, Begent RH.
    Cancer Res; 1999 Aug 15; 59(16):3998-4003. PubMed ID: 10463598
    [Abstract] [Full Text] [Related]

  • 15. Enhanced antitumor activity for the thymidylate synthase inhibitor 1843U89 through decreased host toxicity with oral folic acid.
    Smith GK, Amyx H, Boytos CM, Duch DS, Ferone R, Wilson HR.
    Cancer Res; 1995 Dec 15; 55(24):6117-25. PubMed ID: 8521402
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and preliminary in vitro screening of lipophilic alpha, gamma-bis(amides) as potential prodrugs of methotrexate.
    Pignatello R, Sorrenti V, Spampinato G, Pecora T, Panico A, Di Giacomo C, Fresta M, Vanella A, Puglisi G.
    Anticancer Drug Des; 1996 Apr 15; 11(3):253-64. PubMed ID: 8663912
    [Abstract] [Full Text] [Related]

  • 17. Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.
    Drori S, Jansen G, Mauritz R, Peters GJ, Assaraf YG.
    J Biol Chem; 2000 Oct 06; 275(40):30855-63. PubMed ID: 10899164
    [Abstract] [Full Text] [Related]

  • 18. Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
    van der Wilt CL, Backus HH, Smid K, Comijn L, Veerman G, Wouters D, Voorn DA, Priest DG, Bunni MA, Mitchell F, Jackman AL, Jansen G, Peters GJ.
    Cancer Res; 2001 May 01; 61(9):3675-81. PubMed ID: 11325838
    [Abstract] [Full Text] [Related]

  • 19. Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase.
    Duch DS, Banks S, Dev IK, Dickerson SH, Ferone R, Heath LS, Humphreys J, Knick V, Pendergast W, Singer S.
    Cancer Res; 1993 Feb 15; 53(4):810-8. PubMed ID: 8428362
    [Abstract] [Full Text] [Related]

  • 20. Clinical pharmacokinetics of antitumor antifolates.
    Newell DR.
    Semin Oncol; 1999 Apr 15; 26(2 Suppl 6):74-81. PubMed ID: 10598559
    [Abstract] [Full Text] [Related]

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