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387 related items for PubMed ID: 9918546

  • 1. Biotransformation of coumarin by rodent and human cytochromes P-450: metabolic basis of tissue-selective toxicity in olfactory mucosa of rats and mice.
    Zhuo X, Gu J, Zhang QY, Spink DC, Kaminsky LS, Ding X.
    J Pharmacol Exp Ther; 1999 Feb; 288(2):463-71. PubMed ID: 9918546
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  • 2. Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1: role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal microsomes.
    Gu J, Zhang QY, Genter MB, Lipinskas TW, Negishi M, Nebert DW, Ding X.
    J Pharmacol Exp Ther; 1998 Jun; 285(3):1287-95. PubMed ID: 9618435
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  • 3. Targeted disruption of the olfactory mucosa-specific Cyp2g1 gene: impact on acetaminophen toxicity in the lateral nasal gland, and tissue-selective effects on Cyp2a5 expression.
    Zhuo X, Gu J, Behr MJ, Swiatek PJ, Cui H, Zhang QY, Xie Y, Collins DN, Ding X.
    J Pharmacol Exp Ther; 2004 Feb; 308(2):719-28. PubMed ID: 14610229
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  • 4. Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse.
    Genter MB, Liang HC, Gu J, Ding X, Negishi M, McKinnon RA, Nebert DW.
    Biochem Pharmacol; 1998 Jun 01; 55(11):1819-26. PubMed ID: 9714300
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  • 5. Baculovirus-mediated expression and characterization of rat CYP2A3 and human CYP2a6: role in metabolic activation of nasal toxicants.
    Liu C, Zhuo X, Gonzalez FJ, Ding X.
    Mol Pharmacol; 1996 Oct 01; 50(4):781-8. PubMed ID: 8863822
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  • 6. CYP2A5-mediated activation and early ultrastructural changes in the olfactory mucosa: studies on 2,6-dichlorophenyl methylsulfone.
    Franzén A, Carlsson C, Hermansson V, Lang M, Brittebo EB.
    Drug Metab Dispos; 2006 Jan 01; 34(1):61-8. PubMed ID: 16221755
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  • 7. Nasal cytochrome P450 2A: identification, regional localization, and metabolic activity toward hexamethylphosphoramide, a known nasal carcinogen.
    Thornton-Manning JR, Nikula KJ, Hotchkiss JA, Avila KJ, Rohrbacher KD, Ding X, Dahl AR.
    Toxicol Appl Pharmacol; 1997 Jan 01; 142(1):22-30. PubMed ID: 9007030
    [Abstract] [Full Text] [Related]

  • 8. Coumarin metabolism by rat esophageal microsomes and cytochrome P450 2A3.
    von Weymarn LB, Murphy SE.
    Chem Res Toxicol; 2001 Oct 01; 14(10):1386-92. PubMed ID: 11599930
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  • 9. Metabolic activation of o-phenylphenol to a major cytotoxic metabolite, phenylhydroquinone: role of human CYP1A2 and rat CYP2C11/CYP2E1.
    Ozawa S, Ohta K, Miyajima A, Kurebayashi H, Sunouchi M, Shimizu M, Murayama N, Matsumoto Y, Fukuoka M, Ohno Y.
    Xenobiotica; 2000 Oct 01; 30(10):1005-17. PubMed ID: 11315102
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  • 12. Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.
    Hu J, Sheng L, Li L, Zhou X, Xie F, D'Agostino J, Li Y, Ding X.
    Drug Metab Dispos; 2014 Jan 01; 42(1):23-7. PubMed ID: 24104196
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  • 15. Bioactivation of coumarin in rat olfactory mucosal microsomes: Detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts.
    Zhuo X, Zhao W, Zheng J, Humphreys WG, Shu YZ, Zhu M.
    Chem Biol Interact; 2009 Oct 07; 181(2):227-35. PubMed ID: 19576871
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  • 20. High variability of nitrosamine metabolism among individuals: role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodiethylamine in mice and humans.
    Camus AM, Geneste O, Honkakoski P, Béréziat JC, Henderson CJ, Wolf CR, Bartsch H, Lang MA.
    Mol Carcinog; 1993 Oct 07; 7(4):268-75. PubMed ID: 8352885
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