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Journal Abstract Search

157 related items for PubMed ID: 9934484

  • 21. Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus.
    Lu Z, Raghavan S, Bohn J, Charest M, Stahlhut MW, Rutkowski CA, Simcoe AL, Olsen DB, Schleif WA, Carella A, Gabryelski L, Jin L, Lin JH, Emini E, Chapman K, Tata JR.
    Bioorg Med Chem Lett; 2003 May 19; 13(10):1821-4. PubMed ID: 12729673
    [Abstract] [Full Text] [Related]

  • 22. Design and synthesis of highly potent HIV-1 protease inhibitors with novel isosorbide-derived P2 ligands.
    Qiu X, Zhao GD, Tang LQ, Liu ZP.
    Bioorg Med Chem Lett; 2014 Jun 01; 24(11):2465-8. PubMed ID: 24767846
    [Abstract] [Full Text] [Related]

  • 23. Improved P1/P1' substituents for cyclic urea based HIV-1 protease inhibitors: synthesis, structure-activity relationship, and X-ray crystal structure analysis.
    Nugiel DA, Jacobs K, Cornelius L, Chang CH, Jadhav PK, Holler ER, Klabe RM, Bacheler LT, Cordova B, Garber S, Reid C, Logue KA, Gorey-Feret LJ, Lam GN, Erickson-Viitanen S, Seitz SP.
    J Med Chem; 1997 May 09; 40(10):1465-74. PubMed ID: 9154969
    [Abstract] [Full Text] [Related]

  • 24. Synthesis and antiviral activity of new anti-HIV amprenavir bioisosteres.
    Rocheblave L, Bihel F, De Michelis C, Priem G, Courcambeck J, Bonnet B, Chermann JC, Kraus JL.
    J Med Chem; 2002 Jul 18; 45(15):3321-4. PubMed ID: 12109915
    [Abstract] [Full Text] [Related]

  • 25. Design and synthesis of novel HIV-1 protease inhibitors incorporating oxyindoles as the P2'-ligands.
    Ghosh AK, Schiltz G, Perali RS, Leshchenko S, Kay S, Walters DE, Koh Y, Maeda K, Mitsuya H.
    Bioorg Med Chem Lett; 2006 Apr 01; 16(7):1869-73. PubMed ID: 16480871
    [Abstract] [Full Text] [Related]

  • 26. Design and synthesis of potent C(2)-symmetric diol-based HIV-1 protease inhibitors: effects of fluoro substitution.
    Pyring D, Lindberg J, Rosenquist A, Zuccarello G, Kvarnström I, Zhang H, Vrang L, Unge T, Classon B, Hallberg A, Samuelsson B.
    J Med Chem; 2001 Sep 13; 44(19):3083-91. PubMed ID: 11543677
    [Abstract] [Full Text] [Related]

  • 27. 4-hydroxy-5,6-dihydropyrones. 2. Potent non-peptide inhibitors of HIV protease.
    Tait BD, Hagen S, Domagala J, Ellsworth EL, Gajda C, Hamilton HW, Prasad JV, Ferguson D, Graham N, Hupe D, Nouhan C, Tummino PJ, Humblet C, Lunney EA, Pavlovsky A, Rubin J, Gracheck SJ, Baldwin ET, Bhat TN, Erickson JW, Gulnik SV, Liu B.
    J Med Chem; 1997 Nov 07; 40(23):3781-92. PubMed ID: 9371244
    [Abstract] [Full Text] [Related]

  • 28. Design and fast synthesis of C-terminal duplicated potent C(2)-symmetric P1/P1'-modified HIV-1 protease inhibitors.
    Alterman M, Andersson HO, Garg N, Ahlsén G, Lövgren S, Classon B, Danielson UH, Kvarnström I, Vrang L, Unge T, Samuelsson B, Hallberg A.
    J Med Chem; 1999 Sep 23; 42(19):3835-44. PubMed ID: 10508432
    [Abstract] [Full Text] [Related]

  • 29. Nonsymmetric P2/P2' cyclic urea HIV protease inhibitors. Structure-activity relationship, bioavailability, and resistance profile of monoindazole-substituted P2 analogues.
    De Lucca GV, Kim UT, Liang J, Cordova B, Klabe RM, Garber S, Bacheler LT, Lam GN, Wright MR, Logue KA, Erickson-Viitanen S, Ko SS, Trainor GL.
    J Med Chem; 1998 Jun 18; 41(13):2411-23. PubMed ID: 9632373
    [Abstract] [Full Text] [Related]

  • 30. Structure-based design: synthesis and biological evaluation of a series of novel cycloamide-derived HIV-1 protease inhibitors.
    Ghosh AK, Swanson LM, Cho H, Leshchenko S, Hussain KA, Kay S, Walters DE, Koh Y, Mitsuya H.
    J Med Chem; 2005 May 19; 48(10):3576-85. PubMed ID: 15887965
    [Abstract] [Full Text] [Related]

  • 31. Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance.
    Ghosh AK, Sridhar PR, Leshchenko S, Hussain AK, Li J, Kovalevsky AY, Walters DE, Wedekind JE, Grum-Tokars V, Das D, Koh Y, Maeda K, Gatanaga H, Weber IT, Mitsuya H.
    J Med Chem; 2006 Aug 24; 49(17):5252-61. PubMed ID: 16913714
    [Abstract] [Full Text] [Related]

  • 32. Design and synthesis of selenazole-substituted ritonavir analogs.
    Qiao J, Zhao C, Liu J, Du Y.
    Bioorg Med Chem Lett; 2018 Aug 01; 28(14):2379-2381. PubMed ID: 29934245
    [Abstract] [Full Text] [Related]

  • 33. Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structural Studies, and Biological Evaluation.
    Ghosh AK, Osswald HL, Glauninger K, Agniswamy J, Wang YF, Hayashi H, Aoki M, Weber IT, Mitsuya H.
    J Med Chem; 2016 Jul 28; 59(14):6826-37. PubMed ID: 27389367
    [Abstract] [Full Text] [Related]

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  • 35. Design, synthesis, and biological evaluation of anti-HIV double-drugs. conjugates of HIV protease inhibitors with a reverse transcriptase inhibitor through spontaneously cleavable linkers.
    Matsumoto H, Kimura T, Hamawaki T, Kumagai A, Goto T, Sano K, Hayashi Y, Kiso Y.
    Bioorg Med Chem; 2001 Jun 28; 9(6):1589-600. PubMed ID: 11408178
    [Abstract] [Full Text] [Related]

  • 36. Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands.
    Ghosh AK, Jadhav RD, Simpson H, Kovela S, Osswald H, Agniswamy J, Wang YF, Hattori SI, Weber IT, Mitsuya H.
    Eur J Med Chem; 2018 Dec 05; 160():171-182. PubMed ID: 30340140
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  • 38. Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors possessing augmented P2' side chains.
    Smith AB, Charnley AK, Harada H, Beiger JJ, Cantin LD, Kenesky CS, Hirschmann R, Munshi S, Olsen DB, Stahlhut MW, Schleif WA, Kuo LC.
    Bioorg Med Chem Lett; 2006 Feb 15; 16(4):859-63. PubMed ID: 16298527
    [Abstract] [Full Text] [Related]

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  • 40. Potent HIV-1 protease inhibitors incorporating meso-bicyclic urethanes as P2-ligands: structure-based design, synthesis, biological evaluation and protein-ligand X-ray studies.
    Ghosh AK, Gemma S, Takayama J, Baldridge A, Leshchenko-Yashchuk S, Miller HB, Wang YF, Kovalevsky AY, Koh Y, Weber IT, Mitsuya H.
    Org Biomol Chem; 2008 Oct 21; 6(20):3703-13. PubMed ID: 18843400
    [Abstract] [Full Text] [Related]

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