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225 related items for PubMed ID: 9950274

  • 1. Acyloxyalkoxy-based cyclic prodrugs of opioid peptides: evaluation of the chemical and enzymatic stability as well as their transport properties across Caco-2 cell monolayers.
    Bak A, Gudmundsson OS, Friis GJ, Siahaan TJ, Borchardt RT.
    Pharm Res; 1999 Jan; 16(1):24-9. PubMed ID: 9950274
    [Abstract] [Full Text] [Related]

  • 2. Phenylpropionic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeation.
    Gudmundsson OS, Nimkar K, Gangwar S, Siahaan T, Borchardt RT.
    Pharm Res; 1999 Jan; 16(1):16-23. PubMed ID: 9950273
    [Abstract] [Full Text] [Related]

  • 3. Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability.
    Gudmundsson OS, Pauletti GM, Wang W, Shan D, Zhang H, Wang B, Borchardt RT.
    Pharm Res; 1999 Jan; 16(1):7-15. PubMed ID: 9950272
    [Abstract] [Full Text] [Related]

  • 4. A modified coumarinic acid-based cyclic prodrug of an opioid peptide: its enzymatic and chemical stability and cell permeation characteristics.
    Ouyang H, Tang F, Siahaan TJ, Borchardt RT.
    Pharm Res; 2002 Jun; 19(6):794-801. PubMed ID: 12134949
    [Abstract] [Full Text] [Related]

  • 5. Esterase-sensitive cyclic prodrugs of peptides: evaluation of an acyloxyalkoxy promoiety in a model hexapeptide.
    Pauletti GM, Gangwar S, Okumu FW, Siahaan TJ, Stella VJ, Borchardt RT.
    Pharm Res; 1996 Nov; 13(11):1615-23. PubMed ID: 8956324
    [Abstract] [Full Text] [Related]

  • 6. Optimizing oral absorption of peptides using prodrug strategies.
    Borchardt RT.
    J Control Release; 1999 Nov 01; 62(1-2):231-8. PubMed ID: 10518655
    [Abstract] [Full Text] [Related]

  • 7. Stability of oxymethyl-modified coumarinic acid cyclic prodrugs of diastereomeric opioid peptides in biological media from various animal species including human.
    Liederer BM, Borchardt RT.
    J Pharm Sci; 2005 Oct 01; 94(10):2198-206. PubMed ID: 16136552
    [Abstract] [Full Text] [Related]

  • 8. Effects of amino acid chirality and the chemical linker on the cell permeation characteristics of cyclic prodrugs of opioid peptides.
    Liederer BM, Fuchs T, Vander Velde D, Siahaan TJ, Borchardt RT.
    J Med Chem; 2006 Feb 23; 49(4):1261-70. PubMed ID: 16480263
    [Abstract] [Full Text] [Related]

  • 9. The effect of conformation of the acyloxyalkoxy-based cyclic prodrugs of opioid peptides on their membrane permeability.
    Gudmundsson OS, Vander Velde DG, Jois SD, Bak A, Siahaan TJ, Borchardt RT.
    J Pept Res; 1999 Apr 23; 53(4):403-13. PubMed ID: 10406218
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using an (acyloxy)alkoxy linker.
    Bak A, Siahaan TJ, Gudmundsson OS, Gangwar S, Friis GJ, Borchardt RT.
    J Pept Res; 1999 Apr 23; 53(4):393-402. PubMed ID: 10406217
    [Abstract] [Full Text] [Related]

  • 11. Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using coumarinic acid and phenylpropionic acid linkers.
    Wang B, Nimkar K, Wang W, Zhang H, Shan D, Gudmundsson O, Gangwar S, Siahaan T, Borchardt RT.
    J Pept Res; 1999 Apr 23; 53(4):370-82. PubMed ID: 10406215
    [Abstract] [Full Text] [Related]

  • 12. Evaluation of the permeation characteristics of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs across the blood-brain barrier using an in situ perfused rat brain model.
    Chen W, Yang JZ, Andersen R, Nielsen LH, Borchardt RT.
    J Pharmacol Exp Ther; 2002 Nov 23; 303(2):849-57. PubMed ID: 12388672
    [Abstract] [Full Text] [Related]

  • 13. Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of an acyloxyalkoxy-based cyclic prodrug of the opioid peptide DADLE.
    Tang F, Borchardt RT.
    Pharm Res; 2002 Jun 23; 19(6):780-6. PubMed ID: 12134947
    [Abstract] [Full Text] [Related]

  • 14. Significant differences in the disposition of cyclic prodrugs of opioid peptides in rats and guinea pigs following IV administration.
    Liederer BM, Phan KT, Ouyang H, Borchardt RT.
    J Pharm Sci; 2005 Dec 23; 94(12):2676-87. PubMed ID: 16258984
    [Abstract] [Full Text] [Related]

  • 15. In vitro stability and in vivo pharmacokinetic studies of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs.
    Yang JZ, Chen W, Borchardt RT.
    J Pharmacol Exp Ther; 2002 Nov 23; 303(2):840-8. PubMed ID: 12388671
    [Abstract] [Full Text] [Related]

  • 16. Esterase-sensitive cyclic prodrugs of peptides: evaluation of a phenylpropionic acid promoiety in a model hexapeptide.
    Pauletti GM, Gangwar S, Wang B, Borchardt RT.
    Pharm Res; 1997 Jan 23; 14(1):11-7. PubMed ID: 9034215
    [Abstract] [Full Text] [Related]

  • 17. A comparison of the bioconversion rates and the Caco-2 cell permeation characteristics of coumarin-based cyclic prodrugs and methylester-based linear prodrugs of RGD peptidomimetics.
    Camenisch GP, Wang W, Wang B, Borchardt RT.
    Pharm Res; 1998 Aug 23; 15(8):1174-81. PubMed ID: 9706046
    [Abstract] [Full Text] [Related]

  • 18. Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of the coumarinic acid-based cyclic prodrug of the opioid peptide DADLE.
    Tang F, Borchardt RT.
    Pharm Res; 2002 Jun 23; 19(6):787-93. PubMed ID: 12134948
    [Abstract] [Full Text] [Related]

  • 19. Factors that restrict the intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part I. Role of efflux transporters in the intestinal mucosa.
    Ouyang H, Chen W, Andersen TE, Steffansen B, Borchardt RT.
    J Pharm Sci; 2009 Jan 23; 98(1):337-48. PubMed ID: 18537149
    [Abstract] [Full Text] [Related]

  • 20. Synthesis and conformational analysis of a coumarinic acid-based cyclic prodrug of an opioid peptide with modified sensitivity to esterase-catalyzed bioconversion.
    Ouyang H, Vander Velde DG, Borchardt RT, Siahaan TJ.
    J Pept Res; 2002 Apr 23; 59(4):183-95. PubMed ID: 11972752
    [Abstract] [Full Text] [Related]

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