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Journal Abstract Search

152 related items for PubMed ID: 9986709

  • 1. The presence of substituents on the aryl moiety of the aryl phosphoramidate derivative of d4T enhances anti-HIV efficacy in cell culture: A structure-activity relationship.
    Siddiqui AQ, Ballatore C, McGuigan C, De Clercq E, Balzarini J.
    J Med Chem; 1999 Feb 11; 42(3):393-9. PubMed ID: 9986709
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  • 2. Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite.
    McGuigan C, Cahard D, Sheeka HM, De Clercq E, Balzarini J.
    J Med Chem; 1996 Apr 12; 39(8):1748-53. PubMed ID: 8648614
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  • 3. Synthesis and anti-HIV activity of some novel chain-extended phosphoramidate derivatives of d4T (stavudine): esterase hydrolysis as a rapid predictive test for antiviral potency.
    McGuigan C, Tsang HW, Sutton PW, De Clercq E, Balzarini J.
    Antivir Chem Chemother; 1998 Mar 12; 9(2):109-15. PubMed ID: 9875382
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  • 7. D4T-5'-[p-bromophenyl methoxyalaninyl phosphate] as a potent and non-toxic anti-human immunodeficiency virus agent.
    Vig R, Venkatachalam TK, Uckun FM.
    Antivir Chem Chemother; 1998 Sep 12; 9(5):445-8. PubMed ID: 9875398
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  • 8. Bis-cycloSal-d4T-monophosphates: drugs that deliver two molecules of bioactive nucleotides.
    Ducho C, Görbig U, Jessel S, Gisch N, Balzarini J, Meier C.
    J Med Chem; 2007 Mar 22; 50(6):1335-46. PubMed ID: 17328534
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  • 9. Metabolism and anti-HIV activity of phosphoramidate derivatives of D4T-MP with variations in the amino acid moiety.
    Naesens L, Cahard D, Salgado A, Bidois L, De Clercq E, McGuigan C, Balzarini J.
    Adv Exp Med Biol; 1998 Mar 22; 431():753-7. PubMed ID: 9598164
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  • 10. Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine.
    Saboulard D, Naesens L, Cahard D, Salgado A, Pathirana R, Velazquez S, McGuigan C, De Clercq E, Balzarini J.
    Mol Pharmacol; 1999 Oct 22; 56(4):693-704. PubMed ID: 10496951
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  • 11. Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR.
    Siddiqui AQ, McGuigan C, Ballatore C, Zuccotto F, Gilbert IH, De Clercq E, Balzarini J.
    J Med Chem; 1999 Oct 07; 42(20):4122-8. PubMed ID: 10514282
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  • 12. A comparative study of the hydrolysis pathways of substituted aryl phosphoramidate versus aryl thiophosphoramidate derivatives of stavudine.
    Venkatachalam TK, Yu G, Samuel P, Qazi S, Pendergrass S, Uckun FM.
    Eur J Med Chem; 2004 Aug 07; 39(8):665-83. PubMed ID: 15276300
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  • 17. Polyfluoroaromatic stavudine (d4T) ProTides exhibit enhanced anti-HIV activity.
    Kandil S, Pannecouque C, Chapman FM, Westwell AD, McGuigan C.
    Bioorg Med Chem Lett; 2019 Dec 15; 29(24):126721. PubMed ID: 31679972
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  • 18. Synthesis and in vitro enzymatic and antiviral evaluation of phosphoramidate d4T derivatives as chain terminators.
    Yang S, Pannecouque C, Lescrinier E, Giraut A, Herdewijn P.
    Org Biomol Chem; 2012 Jan 07; 10(1):146-53. PubMed ID: 22069085
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