BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

85 related articles for article (PubMed ID: 29744867)

  • 1. P-glycoprotein (MDR1/ABCB1) restricts brain accumulation and cytochrome P450-3A (CYP3A) limits oral availability of the novel ALK/ROS1 inhibitor lorlatinib.
    Li W; Sparidans RW; Wang Y; Lebre MC; Wagenaar E; Beijnen JH; Schinkel AH
    Int J Cancer; 2018 Oct; 143(8):2029-2038. PubMed ID: 29744867
    [TBL] [Abstract][Full Text] [Related]  

  • 2. ABCB1 attenuates brain exposure to the KRAS
    Rijmers J; Retmana IA; Bui V; Arguedas D; Lebre MC; Sparidans RW; Beijnen JH; Schinkel AH
    Biomed Pharmacother; 2024 Jun; 175():116720. PubMed ID: 38733773
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Coadministration of ABCB1/P-glycoprotein inhibitor elacridar improves tissue distribution of ritonavir-boosted oral cabazitaxel in mice.
    Loos NHC; Martins MLF; de Jong D; Lebre MC; Tibben M; Beijnen JH; Schinkel AH
    Int J Pharm; 2024 Jan; 650():123708. PubMed ID: 38135258
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The ABCB1 and ABCG2 efflux transporters limit brain disposition of the SYK inhibitors entospletinib and lanraplenib.
    Loos NHC; Sparidans RW; Heydari P; Bui V; Lebre MC; Beijnen JH; Schinkel AH
    Toxicol Appl Pharmacol; 2024 Apr; 485():116911. PubMed ID: 38527694
    [TBL] [Abstract][Full Text] [Related]  

  • 5. P-gp/ABCB1 exerts differential impacts on brain and fetal exposure to norbuprenorphine.
    Liao MZ; Gao C; Shireman LM; Phillips B; Risler LJ; Neradugomma NK; Choudhari P; Prasad B; Shen DD; Mao Q
    Pharmacol Res; 2017 May; 119():61-71. PubMed ID: 28111265
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Interplay of OATP1A/1B/2B1 uptake transporters and ABCB1 and ABCG2 efflux transporters in the handling of bilirubin and drugs.
    Li W; Sparidans RW; Wang Y; Martins MLF; de Waart DR; van Tellingen O; Song JY; Lebre MC; van Hoppe S; Wagenaar E; Beijnen JH; Schinkel AH
    Biomed Pharmacother; 2024 Jun; 175():116644. PubMed ID: 38692057
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Evaluation of the Effect of Lorlatinib on CYP2B6, CYP2C9, UGT, and P-Glycoprotein Substrates in Patients with Advanced Non-Small Cell Lung Cancer.
    Chen J; Bearz A; Kim DW; Mamdani H; Bauman J; Chiari R; Ou SI; Solomon BJ; Soo RA; Felip E; Shaw AT; Thurm H; Clancy JS; Lee K; O'Gorman M; Tanski C; Pithavala YK
    Clin Pharmacokinet; 2024 Feb; 63(2):171-182. PubMed ID: 38079095
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Second-trimester medical abortion after exposure to lorlatinib during early pregnancy, a case report.
    Mawet M; Basse C; Barrois M; Gligorov J; Cadranel J; Chabbert-Buffet N; Selleret L
    J Gynecol Obstet Hum Reprod; 2023 Dec; 52(10):102673. PubMed ID: 37777070
    [TBL] [Abstract][Full Text] [Related]  

  • 9. In-depth Analysis of Lorlatinib-related neurocognitive Adverse Events in Patients With Non-small-cell Lung Cancer.
    Schoenmaekers J; Dijkstra J; van der Wekken A; Paats M; Broen M; Brandts L; Dingemans AM; Hendriks L
    Clin Lung Cancer; 2024 Mar; 25(2):168-174.e1. PubMed ID: 38151408
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pharmacokinetics of quinacrine efflux from mouse brain via the P-glycoprotein efflux transporter.
    Ahn M; Ghaemmaghami S; Huang Y; Phuan PW; May BC; Giles K; DeArmond SJ; Prusiner SB
    PLoS One; 2012; 7(7):e39112. PubMed ID: 22768295
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Tazemetostat synergistically combats multidrug resistance by the unique triple inhibition of ABCB1, ABCC1, and ABCG2 efflux transporters in vitro and ex vivo.
    Budagaga Y; Sabet Z; Zhang Y; Novotná E; Hanke I; Rozkoš T; Hofman J
    Biochem Pharmacol; 2023 Oct; 216():115769. PubMed ID: 37634597
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Bilateral optic neuropathy associated with lorlatinib monotherapy for ALK-positive metastatic lung adenocarcinoma.
    Kong AW; Engelmann AR; Hosseini M; Bonelli L
    Am J Ophthalmol Case Rep; 2024 Jun; 34():102063. PubMed ID: 38707952
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Humanization of the Blood-Brain Barrier Transporter ABCB1 in Mice Disrupts Genomic Locus - Lessons from Three Unsuccessful Approaches.
    Krohn M; Wanek T; Menet MC; Noack A; Declèves X; Langer O; Löscher W; Pahnke J
    Eur J Microbiol Immunol (Bp); 2018 Sep; 8(3):78-86. PubMed ID: 30345087
    [TBL] [Abstract][Full Text] [Related]  

  • 14. ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models.
    Bugide S; Reddy DS; Malvi P; Gupta R; Wajapeyee N
    iScience; 2024 May; 27(5):109800. PubMed ID: 38741708
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Differential network analysis of ROS1 inhibitors reveals lorlatinib polypharmacology through co-targeting PYK2.
    Liao Y; Remsing Rix LL; Li X; Fang B; Izumi V; Welsh EA; Monastyrskyi A; Haura EB; Koomen JM; Doebele RC; Rix U
    Cell Chem Biol; 2024 Feb; 31(2):284-297.e10. PubMed ID: 37848034
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A case study on severe psychiatric symptoms induced by lorlatinib.
    Liu MA; Xu E; Shu CA
    Psychooncology; 2024 Jan; 33(1):e6283. PubMed ID: 38282214
    [No Abstract]   [Full Text] [Related]  

  • 17. Lorlatinib in ALK- and ROS1-positive NSCLC: the future has a start.
    Facchinetti F; Friboulet L
    Transl Lung Cancer Res; 2018 Apr; 7(Suppl 2):S103-S106. PubMed ID: 29782561
    [No Abstract]   [Full Text] [Related]  

  • 18. Lorlatinib Treatment Elicits Multiple On- and Off-Target Mechanisms of Resistance in ALK-Driven Cancer.
    Redaelli S; Ceccon M; Zappa M; Sharma GG; Mastini C; Mauri M; Nigoghossian M; Massimino L; Cordani N; Farina F; Piazza R; Gambacorti-Passerini C; Mologni L
    Cancer Res; 2018 Dec; 78(24):6866-6880. PubMed ID: 30322862
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Lorlatinib in patients with ALK-positive non-small-cell lung cancer: results from a global phase 2 study.
    Solomon BJ; Besse B; Bauer TM; Felip E; Soo RA; Camidge DR; Chiari R; Bearz A; Lin CC; Gadgeel SM; Riely GJ; Tan EH; Seto T; James LP; Clancy JS; Abbattista A; Martini JF; Chen J; Peltz G; Thurm H; Ou SI; Shaw AT
    Lancet Oncol; 2018 Dec; 19(12):1654-1667. PubMed ID: 30413378
    [TBL] [Abstract][Full Text] [Related]  

  • 20.
    ; ; . PubMed ID:
    [No Abstract]   [Full Text] [Related]  

    [Next]    [New Search]
    of 5.