BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

205 related articles for article (PubMed ID: 36634873)

  • 1. Inhibitors of Keap1-Nrf2 protein-protein interaction reduce estrogen responsive gene expression and oxidative stress in estrogen receptor-positive breast cancer.
    Xie T; Zahid H; Ali AR; Joyce R; Yang G; Winz C; Le Y; Zhou R; Furmanski P; Hu L; Suh N
    Toxicol Appl Pharmacol; 2023 Feb; 460():116375. PubMed ID: 36634873
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 17β-estradiol plays the anti-osteoporosis role via a novel ESR1-Keap1-Nrf2 axis-mediated stress response activation and Tmem119 upregulation.
    Yang R; Li J; Zhang J; Xue Q; Qin R; Wang R; Goltzman D; Miao D
    Free Radic Biol Med; 2023 Feb; 195():231-244. PubMed ID: 36592659
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Estrogen increases Nrf2 activity through activation of the PI3K pathway in MCF-7 breast cancer cells.
    Wu J; Williams D; Walter GA; Thompson WE; Sidell N
    Exp Cell Res; 2014 Nov; 328(2):351-60. PubMed ID: 25172557
    [TBL] [Abstract][Full Text] [Related]  

  • 4. CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation.
    Lu MC; Zhao J; Liu YT; Liu T; Tao MM; You QD; Jiang ZY
    Redox Biol; 2019 Sep; 26():101266. PubMed ID: 31279986
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Nrf2-Keap1 antioxidant defense and cell survival signaling are upregulated by 17β-estradiol in homocysteine-treated dopaminergic SH-SY5Y cells.
    Chen CS; Tseng YT; Hsu YY; Lo YC
    Neuroendocrinology; 2013; 97(3):232-41. PubMed ID: 22948038
    [TBL] [Abstract][Full Text] [Related]  

  • 6. NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress-Induced DPP3-KEAP1 Interaction.
    Lu K; Alcivar AL; Ma J; Foo TK; Zywea S; Mahdi A; Huo Y; Kensler TW; Gatza ML; Xia B
    Cancer Res; 2017 Jun; 77(11):2881-2892. PubMed ID: 28416489
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions.
    Lu MC; Shao HL; Liu T; You QD; Jiang ZY
    Eur J Med Chem; 2020 Dec; 207():112734. PubMed ID: 32866756
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1).
    Bresciani A; Missineo A; Gallo M; Cerretani M; Fezzardi P; Tomei L; Cicero DO; Altamura S; Santoprete A; Ingenito R; Bianchi E; Pacifici R; Dominguez C; Munoz-Sanjuan I; Harper S; Toledo-Sherman L; Park LC
    Arch Biochem Biophys; 2017 Oct; 631():31-41. PubMed ID: 28801166
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Expression of xCT and activity of system xc(-) are regulated by NRF2 in human breast cancer cells in response to oxidative stress.
    Habib E; Linher-Melville K; Lin HX; Singh G
    Redox Biol; 2015 Aug; 5():33-42. PubMed ID: 25827424
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design, Synthesis, and Structure-Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors.
    Zhou HS; Hu LB; Zhang H; Shan WX; Wang Y; Li X; Liu T; Zhao J; You QD; Jiang ZY
    J Med Chem; 2020 Oct; 63(19):11149-11168. PubMed ID: 32902980
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Development of a Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for the Inhibition of Keap1-Nrf2 Protein-Protein Interaction.
    Lee S; Abed DA; Beamer LJ; Hu L
    SLAS Discov; 2021 Jan; 26(1):100-112. PubMed ID: 32564647
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The oncoprotein HBXIP competitively binds KEAP1 to activate NRF2 and enhance breast cancer cell growth and metastasis.
    Zhou XL; Zhu CY; Wu ZG; Guo X; Zou W
    Oncogene; 2019 May; 38(21):4028-4046. PubMed ID: 30692632
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Reduced formation of depurinating estrogen-DNA adducts by sulforaphane or KEAP1 disruption in human mammary epithelial MCF-10A cells.
    Yang L; Zahid M; Liao Y; Rogan EG; Cavalieri EL; Davidson NE; Yager JD; Visvanathan K; Groopman JD; Kensler TW
    Carcinogenesis; 2013 Nov; 34(11):2587-92. PubMed ID: 23843041
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Emerging Substrate Proteins of Kelch-like ECH Associated Protein 1 (Keap1) and Potential Challenges for the Development of Small-Molecule Inhibitors of the Keap1-Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Protein-Protein Interaction.
    Zhang Y; Shi Z; Zhou Y; Xiao Q; Wang H; Peng Y
    J Med Chem; 2020 Aug; 63(15):7986-8002. PubMed ID: 32233486
    [TBL] [Abstract][Full Text] [Related]  

  • 15. NRF2 activation by reversible KEAP1 binding induces the antioxidant response in primary neurons and astrocytes of a Huntington's disease mouse model.
    Moretti D; Tambone S; Cerretani M; Fezzardi P; Missineo A; Sherman LT; Munoz-Sajuan I; Harper S; Dominquez C; Pacifici R; Tomei L; Park L; Bresciani A
    Free Radic Biol Med; 2021 Jan; 162():243-254. PubMed ID: 33096251
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural modification of C2-substituents on 1,4-bis(arylsulfonamido)benzene or naphthalene-N,N'-diacetic acid derivatives as potent inhibitors of the Keap1-Nrf2 protein-protein interaction.
    Lee S; Ali AR; Abed DA; Nguyen MU; Verzi MP; Hu L
    Eur J Med Chem; 2024 Feb; 265():116104. PubMed ID: 38159482
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Medicinal Chemistry Insights into the Development of Small-Molecule Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors.
    Zhao Z; Dong R; You Q; Jiang Z
    J Med Chem; 2023 Jul; 66(14):9325-9344. PubMed ID: 37441735
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Nrf2-Keap1 pathway-mediated effects of resveratrol on oxidative stress and apoptosis in hydrogen peroxide-treated rheumatoid arthritis fibroblast-like synoviocytes.
    Zhang Y; Wang G; Wang T; Cao W; Zhang L; Chen X
    Ann N Y Acad Sci; 2019 Dec; 1457(1):166-178. PubMed ID: 31475364
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design, synthesis and evaluation of novel small molecules acting as Keap1-Nrf2 protein-protein interaction inhibitors.
    Sun Y; Zheng L; Yang B; Ge S; Li Q; Zhang M; Shen S; Ying Y
    J Enzyme Inhib Med Chem; 2022 Dec; 37(1):2575-2588. PubMed ID: 36128875
    [TBL] [Abstract][Full Text] [Related]  

  • 20.
    Hu X; Mu L; Zhu L; Chang X; Nie L; Wang L; Li G
    Mol Med Rep; 2021 Sep; 24(3):. PubMed ID: 34278476
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.