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  • Title: Treatment of childhood migraine attacks with oral zolmitriptan and ibuprofen.
    Author: Evers S, Rahmann A, Kraemer C, Kurlemann G, Debus O, Husstedt IW, Frese A.
    Journal: Neurology; 2006 Aug 08; 67(3):497-9. PubMed ID: 16775229.
    The authors conducted a double-blind, placebo-controlled, crossover study to investigate the efficacy of oral zolmitriptan in the treatment of migraine in children and adolescents. Patients (n = 32) received placebo, zolmitriptan 2.5 mg, and ibuprofen 200 to 400 mg to treat three consecutive migraine attacks. Pain relief rates after 2 hours were 28% for placebo, 62% for zolmitriptan, and 69% for ibuprofen (p < 0.05). Both drugs are well tolerated with only mild side effects.
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